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Questions and Answers
What is the main enzyme inhibited by the drugs discussed in the chapter?
What is the main enzyme inhibited by the drugs discussed in the chapter?
- ACE
- LOX
- COX-1
- COX-2 (correct)
Which group of NSAIDs selectively inhibits COX-2?
Which group of NSAIDs selectively inhibits COX-2?
- First-generation NSAIDs
- Second-generation NSAIDs (correct)
- Acetaminophen
- None of the above
What can the inhibition of COX-1 cause?
What can the inhibition of COX-1 cause?
- Suppression of inflammation
- Relief of mild to moderate pain
- Renal impairment (correct)
- Prevention of MI and stroke
What are the major beneficial actions of aspirin as mentioned in the text?
What are the major beneficial actions of aspirin as mentioned in the text?
Why do the antiplatelet effects of a single dose of aspirin persist for the life of the platelet?
Why do the antiplatelet effects of a single dose of aspirin persist for the life of the platelet?
Which form of COX is responsible for the prevention of MI and stroke by aspirin?
Which form of COX is responsible for the prevention of MI and stroke by aspirin?
What type of doses of aspirin are typically higher than analgesic or antipyretic doses?
What type of doses of aspirin are typically higher than analgesic or antipyretic doses?
Which condition can aspirin be particularly useful for?
Which condition can aspirin be particularly useful for?
What effect can high-dose aspirin have on postoperative pain when compared to opioids?
What effect can high-dose aspirin have on postoperative pain when compared to opioids?
How can the risk of aspirin-induced gastric ulcers be reduced?
How can the risk of aspirin-induced gastric ulcers be reduced?
What should patients do to minimize the interaction between aspirin and other NSAIDs, like ibuprofen or naproxen?
What should patients do to minimize the interaction between aspirin and other NSAIDs, like ibuprofen or naproxen?
In which patient population should aspirin be avoided due to the risk of Reye syndrome?
In which patient population should aspirin be avoided due to the risk of Reye syndrome?
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