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Pharmacology: COX Inhibitors Classification

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Pharmacology: COX Inhibitors Classification

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Questions and Answers

What is the main enzyme inhibited by the drugs discussed in the chapter?

ACE

LOX

COX-1

COX-2 (correct)

Which group of NSAIDs selectively inhibits COX-2?

First-generation NSAIDs

Second-generation NSAIDs (correct)

Acetaminophen

None of the above

What can the inhibition of COX-1 cause?

Suppression of inflammation

Relief of mild to moderate pain

Renal impairment (correct)

Prevention of MI and stroke

What are the major beneficial actions of aspirin as mentioned in the text?

Suppression of inflammation, relief of mild to moderate pain, reduction of fever, and prevention of MI and stroke Signup and view all the answers

Why do the antiplatelet effects of a single dose of aspirin persist for the life of the platelet?

Because platelets cannot synthesize new COX Signup and view all the answers

Which form of COX is responsible for the prevention of MI and stroke by aspirin?

COX-1 Signup and view all the answers

What type of doses of aspirin are typically higher than analgesic or antipyretic doses?

Antiinflammatory doses Signup and view all the answers

Which condition can aspirin be particularly useful for?

Rheumatoid arthritis Signup and view all the answers

What effect can high-dose aspirin have on postoperative pain when compared to opioids?

Equally effective Signup and view all the answers

How can the risk of aspirin-induced gastric ulcers be reduced?

Testing for H.pylori and using PPI or H2RA Signup and view all the answers

What should patients do to minimize the interaction between aspirin and other NSAIDs, like ibuprofen or naproxen?

Take other NSAIDs 2 hours before aspirin Signup and view all the answers

In which patient population should aspirin be avoided due to the risk of Reye syndrome?

Children with asthma Signup and view all the answers