12 Questions
What is the main enzyme inhibited by the drugs discussed in the chapter?
COX-2
Which group of NSAIDs selectively inhibits COX-2?
Second-generation NSAIDs
What can the inhibition of COX-1 cause?
Renal impairment
What are the major beneficial actions of aspirin as mentioned in the text?
Suppression of inflammation, relief of mild to moderate pain, reduction of fever, and prevention of MI and stroke
Why do the antiplatelet effects of a single dose of aspirin persist for the life of the platelet?
Because platelets cannot synthesize new COX
Which form of COX is responsible for the prevention of MI and stroke by aspirin?
COX-1
What type of doses of aspirin are typically higher than analgesic or antipyretic doses?
Antiinflammatory doses
Which condition can aspirin be particularly useful for?
Rheumatoid arthritis
What effect can high-dose aspirin have on postoperative pain when compared to opioids?
Equally effective
How can the risk of aspirin-induced gastric ulcers be reduced?
Testing for H.pylori and using PPI or H2RA
What should patients do to minimize the interaction between aspirin and other NSAIDs, like ibuprofen or naproxen?
Take other NSAIDs 2 hours before aspirin
In which patient population should aspirin be avoided due to the risk of Reye syndrome?
Children with asthma
Learn about the classification of drugs that inhibit COX enzyme, including NSAIDs and acetaminophen. Understand the different types of COX inhibitors such as first-generation NSAIDs that inhibit both COX-1 and COX-2, and second-generation NSAIDs that selectively inhibit COX-2.
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