Podcast
Questions and Answers
What primary function do glucocorticoids serve in the body?
What primary function do glucocorticoids serve in the body?
- Stimulate production of sex hormones
- Reduce inflammation and suppress immune response (correct)
- Increase blood potassium levels
- Promote sodium excretion in the kidneys
Which drug acts on mineralocorticoid receptors to manage sodium and water retention?
Which drug acts on mineralocorticoid receptors to manage sodium and water retention?
- Spironolactone
- Cosyntropin
- Fludrocortisone (correct)
- Metyrapone
What is the role of cosyntropin in the adrenal system?
What is the role of cosyntropin in the adrenal system?
- It inhibits adrenal steroidogenesis
- It blocks aldosterone receptors
- It serves as a precursor to adrenal hormones
- It stimulates cortisol production from the adrenal cortex (correct)
What is the purpose of metyrapone in clinical treatment?
What is the purpose of metyrapone in clinical treatment?
What property do adrenal androgens like DHEA possess?
What property do adrenal androgens like DHEA possess?
Flashcards
Glucocorticoids function
Glucocorticoids function
Reduce inflammation, suppress the immune response, and regulate metabolism by altering gene expression through receptors.
Mineralocorticoid effect
Mineralocorticoid effect
Increase sodium and water retention, and potassium excretion in the kidneys, acting by affecting mineralocorticoid receptors.
Adrenal Androgens role
Adrenal Androgens role
Serve as a precursor to sex hormones and have weak androgenic effects.
ACTH's function
ACTH's function
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Corticosteroid Inhibitors purpose
Corticosteroid Inhibitors purpose
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Study Notes
Glucocorticoids
- Glucocorticoids, such as hydrocortisone and prednisone, have powerful effects on the body.
- They work by altering receptors, impacting gene expression.
- This leads to reduced inflammation suppression of the immune response, and regulation of metabolism.
Mineralocorticoids
- Mineralocorticoids, like fludrocortisone, primarily affect the kidneys.
- They act on mineralocorticoid receptors to increase sodium and water retention.
- They also promote potassium excretion.
Adrenal Androgens
- DHEA is an adrenal androgen.
- It's a precursor to sex hormones.
- It also has modest androgenic properties.
ACTH
- Cosyntropin is a synthetic form of ACTH.
- It stimulates the adrenal cortex to produce cortisol.
Corticosteroid Inhibitors
- Metyrapone inhibits enzymes in adrenal steroidogenesis.
- This use is for managing Cushing syndrome and adrenal tumours.
Aldosterone Antagonists
- Spironolactone blocks aldosterone receptors.
- This reduces sodium and water retention, aiding in blood pressure control.
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