5 Questions
Where do corticosteroids combine with receptors to form a macromolecular complex?
Cytoplasm
Which of the following is secreted by the adrenal cortex?
Cortisol
Which of the following corticosteroids is long-acting?
Dexamethasone
How do corticosteroids affect acute inflammation?
Inhibit cytokine release
What is the main pharmacological action of corticosteroids on carbohydrates, protein, and fat metabolism?
Inhibition of metabolism
Study Notes
Corticosteroids
- Corticosteroids combine with receptors to form a macromolecular complex in the cytoplasm of target cells.
Adrenal Cortex Secretion
- The adrenal cortex secretes corticosteroids, which include glucocorticoids and mineralocorticoids.
Long-Acting Corticosteroid
- Dexamethasone is a long-acting corticosteroid.
Anti-Inflammatory Effects
- Corticosteroids reduce acute inflammation by inhibiting the production of chemical mediators that promote inflammation, decreasing the permeability of blood vessels, and reducing the migration of white blood cells to the site of inflammation.
Metabolic Effects
- The main pharmacological action of corticosteroids is to stimulate the breakdown of protein and fat for energy production, increase glucose levels in the blood, and promote the storage of glycogen in the liver.
This quiz provides an overview of corticosteroids pharmacology, focusing on the adrenal cortex secretion, the HPA axis, and the molecular mechanism of action of corticosteroids.
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