PHARM-REview

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Which one of these is an example of a local infection?

Sepsis

Abscesses (correct)

Urinary bladder infections

Septic shock

Which one of these is NOT a determinant of pharmacologic responses of topical products?

Dosing

Permeability

Concentration gradient

Adjunct (correct)

What factors affect drug permeability when applying topical products?

Vehicle and occlusion

Concentration gradient and dosing

Permeability and penetration

Skin condition and location (correct)

Which of the following is a method to achieve occlusion?

Applying an external covering or dressing Signup and view all the answers

What is the main advantage of using ointments as a delivery system?

They are good for dry lesions due to occlusive properties Signup and view all the answers

Which drug is a first-line treatment for androgenic alopecia in both men and women?

Minoxidil (Rogaine) Signup and view all the answers

What are the major adverse effects of finasteride?

Decreased libido and erectile dysfunction Signup and view all the answers

Which of the following is a major systemic side effect of corticosteroids?

Osteoporosis Signup and view all the answers

Which topical corticosteroid should be avoided on the face?

Fluoride-containing corticosteroids Signup and view all the answers

Which dosage forms of corticosteroids have the least risk of systemic side effects?

Topical corticosteroids Signup and view all the answers

What is the danger of sudden discontinuation of chronic, regular use of corticosteroids?

Adrenal crisis Signup and view all the answers

Which category of drugs has shown an adverse effect on the fetus in animal studies and may have potential benefits in pregnant women despite potential risks?

Category C Signup and view all the answers

What are the two subsections included in the 'new' PLLR prescribing information related to pregnancy?

Risk summary and clinical considerations Signup and view all the answers

Which physiologic action of corticosteroids is responsible for their anti-inflammatory and immunosuppressive effects?

Glucocorticoid action Signup and view all the answers

Which systemic corticosteroid has the majority of mineralocorticoid action?

Fludocortisone Signup and view all the answers

Which topical azole is specific for superficial onychomycosis?

Efinaconazole (Jublia) Signup and view all the answers

What is the main use for nystatin?

Treatment of cutaneous or mucocutaneous infections caused by Candida albicans Signup and view all the answers

What is a use for selenium sulfide other than dandruff?

Treatment of Tinea versicolor Signup and view all the answers

What are the uses for tolnaftate?

Treatment of Tinea pedis Signup and view all the answers

Which two topical products are used for burns?

Silver Sulfadiazine and Mafenide Signup and view all the answers

What are first-line options to treat superficial impetigo (i.e., topical)?

Mupirocin or retapamulin Signup and view all the answers

List treatment options for more severe cases of impetigo, as well as erysipelas, and cellulitis.

Risk for MRSA: Doxycycline, minocycline, and Vancomycin Signup and view all the answers

What is the timing requirement for using antiviral drugs to treat oral HSV infection?

PO therapy needs to start within 72 hours Signup and view all the answers

Which is the most common treatment failure of mild acne?

Moderate acne Signup and view all the answers

Which is true about azelaic acid as a treatment for acne?

It causes less irritation and may be chosen first-line for very sensitive skin Signup and view all the answers

What is the mechanism of action for clascoterone?

Topical androgen receptor inhibitor Signup and view all the answers

What is the general place in therapy for systemic antibiotics in the treatment of acne?

Usually for moderate-severe inflammatory acne Signup and view all the answers