Corticosteroid Pharmacological Actions Quiz

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Questions and Answers

Which complication is an occasional abrupt onset of high dose corticosteroid therapy?

  • Avascular necrosis of head of femur (correct)
  • Osteoporosis involving vertebrae
  • Posterior subcapsular cataract
  • Peptic ulceration

Which effect can be prevented/arrested to some extent by calcium supplements + Vitamin D?

  • Psychiatric disturbances
  • Delayed healing of wounds
  • Peptic ulceration
  • Corticosteroid induced osteoporosis (correct)

What complication may develop in susceptible individuals after prolonged topical corticosteroid therapy?

  • Gro'11h retardation
  • Glaucoma (correct)
  • Osteoporosis
  • Psychiatric disturbances

What may occur after several years of use, especially in children, with prolonged corticosteroid therapy?

<p>Posterior subcapsular cataract (C)</p> Signup and view all the answers

Which medication appears safer than dexa/beta methasone during pregnancy due to its reduced fetal exposure?

<p>Prednisolone (B)</p> Signup and view all the answers

Which of the following is a prominent extension of the pharmacological action of corticoids with prolonged therapy?

<p>Mineralocorticoid Sodium and water retention (A)</p> Signup and view all the answers

What is a characteristic appearance associated with Cushing's habitus due to prolonged corticoid therapy?

<p>Rounded face, narrow mouth, supra-clavicular hump, obesity of trunk with relatively thin limbs (D)</p> Signup and view all the answers

What should be done to offset the catabolic state in patients receiving corticosteroid therapy for longer than 2 weeks?

<p>Put them on a high protein, high potassium diet (B)</p> Signup and view all the answers

What is a potential side effect of topical application of corticoids?

<p>Cutaneous atrophy localized to the site (D)</p> Signup and view all the answers

Which symptom warrants withdrawal of corticoids due to prolonged therapy?

<p>Myopathy affecting proximal muscles (D)</p> Signup and view all the answers

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Study Notes

Corticosteroid Complications

  • Abrupt onset of high dose corticosteroid therapy may lead to psychotic episodes.

Osteoporosis Prevention

  • Calcium supplements + Vitamin D can prevent/arrest osteoporosis to some extent.

Topical Corticosteroid Complications

  • Prolonged topical corticosteroid therapy may lead to hypothalamic-pituitary-adrenal axis suppression in susceptible individuals.

Prolonged Corticosteroid Therapy

  • Growth retardation may occur after several years of use, especially in children.
  • Prolonged corticosteroid therapy can lead to hypothalamic-pituitary-adrenal axis suppression.

Pregnancy and Corticosteroids

  • Prednisolone appears safer than dexa/beta methasone during pregnancy due to reduced fetal exposure.

Corticoids Pharmacological Action

  • Prolonged therapy can lead to a prominent extension of the pharmacological action of corticoids, including suppression of hypothalamic-pituitary-adrenal axis.

Cushing's Habitus

  • Prolonged corticoid therapy can lead to a characteristic 'moon face' appearance associated with Cushing's habitus.

Offset Catabolic State

  • To offset the catabolic state in patients receiving corticosteroid therapy for longer than 2 weeks, protein supplements should be given.

Topical Corticoid Side Effects

  • Skin atrophy is a potential side effect of topical application of corticoids.

Corticoid Withdrawal

  • Severe mood changes warrant withdrawal of corticoids due to prolonged therapy.

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