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Questions and Answers
Which complication is an occasional abrupt onset of high dose corticosteroid therapy?
Which effect can be prevented/arrested to some extent by calcium supplements + Vitamin D?
What complication may develop in susceptible individuals after prolonged topical corticosteroid therapy?
What may occur after several years of use, especially in children, with prolonged corticosteroid therapy?
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Which medication appears safer than dexa/beta methasone during pregnancy due to its reduced fetal exposure?
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Which of the following is a prominent extension of the pharmacological action of corticoids with prolonged therapy?
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What is a characteristic appearance associated with Cushing's habitus due to prolonged corticoid therapy?
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What should be done to offset the catabolic state in patients receiving corticosteroid therapy for longer than 2 weeks?
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What is a potential side effect of topical application of corticoids?
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Which symptom warrants withdrawal of corticoids due to prolonged therapy?
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Study Notes
Corticosteroid Complications
- Abrupt onset of high dose corticosteroid therapy may lead to psychotic episodes.
Osteoporosis Prevention
- Calcium supplements + Vitamin D can prevent/arrest osteoporosis to some extent.
Topical Corticosteroid Complications
- Prolonged topical corticosteroid therapy may lead to hypothalamic-pituitary-adrenal axis suppression in susceptible individuals.
Prolonged Corticosteroid Therapy
- Growth retardation may occur after several years of use, especially in children.
- Prolonged corticosteroid therapy can lead to hypothalamic-pituitary-adrenal axis suppression.
Pregnancy and Corticosteroids
- Prednisolone appears safer than dexa/beta methasone during pregnancy due to reduced fetal exposure.
Corticoids Pharmacological Action
- Prolonged therapy can lead to a prominent extension of the pharmacological action of corticoids, including suppression of hypothalamic-pituitary-adrenal axis.
Cushing's Habitus
- Prolonged corticoid therapy can lead to a characteristic 'moon face' appearance associated with Cushing's habitus.
Offset Catabolic State
- To offset the catabolic state in patients receiving corticosteroid therapy for longer than 2 weeks, protein supplements should be given.
Topical Corticoid Side Effects
- Skin atrophy is a potential side effect of topical application of corticoids.
Corticoid Withdrawal
- Severe mood changes warrant withdrawal of corticoids due to prolonged therapy.
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Description
Test your knowledge on the pharmacological actions of corticosteroids and their limitations in chronic diseases. Explore the effects of mineralocorticoids and glucocorticoids, including sodium and water retention, edema, hypokalemic alkalosis, and changes in blood pressure.
