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Questions and Answers
Which type of drugs indirectly activate adrenergic receptors by increasing the release of endogenous catecholamine?
Which type of drugs indirectly activate adrenergic receptors by increasing the release of endogenous catecholamine?
- Agonists
- Parasympathetic drugs
- Antagonists
- Sympathomimetic drugs (correct)
What is the advantage of non-catecholamine agents over endogenous catecholamines?
What is the advantage of non-catecholamine agents over endogenous catecholamines?
- Metabolized by COMPT and MAO enzymes
- Shorter duration of action
- Non-selective activity on adrenergic receptors
- Prolonged duration of action (correct)
Which type of adrenergic receptor does noradrenaline have a strong affinity to?
Which type of adrenergic receptor does noradrenaline have a strong affinity to?
- β2 receptors
- α2 receptors
- α1 receptors (correct)
- β1 receptors
What is the primary factor that limits the systemic use of endogenous catecholamines like adrenaline?
What is the primary factor that limits the systemic use of endogenous catecholamines like adrenaline?
Which type of drugs act on all types of adrenergic receptors including α1, α2, β1, β2, and β3?
Which type of drugs act on all types of adrenergic receptors including α1, α2, β1, β2, and β3?
What is the dose-dependent activity of dopamine on?
What is the dose-dependent activity of dopamine on?
Which type of shock is adrenaline used to treat?
Which type of shock is adrenaline used to treat?
Which receptor does adrenaline act on to reverse the hypotension and bronchoconstriction caused by histamine in anaphylactic shock?
Which receptor does adrenaline act on to reverse the hypotension and bronchoconstriction caused by histamine in anaphylactic shock?
In which type of shock is noradrenaline the preferred agent?
In which type of shock is noradrenaline the preferred agent?
For what emergency use can adrenaline be given intramuscularly?
For what emergency use can adrenaline be given intramuscularly?
What effect does adrenaline have when locally administered for its vasoconstrictor effect?
What effect does adrenaline have when locally administered for its vasoconstrictor effect?
Which drug increases the release of noradrenaline from synaptic vesicles and can be used orally for its decongestant effect in case of common cold?
Which drug increases the release of noradrenaline from synaptic vesicles and can be used orally for its decongestant effect in case of common cold?
Why should pseudoephedrine be used cautiously in hypertensive patients?
Why should pseudoephedrine be used cautiously in hypertensive patients?
What does the selectivity on the α-receptors in selective α-receptor agonists help to avoid?
What does the selectivity on the α-receptors in selective α-receptor agonists help to avoid?
What is the main reason for using selective α-receptor agonists?
What is the main reason for using selective α-receptor agonists?
What is the main scope of clinical uses of selective α-receptor agonists?
What is the main scope of clinical uses of selective α-receptor agonists?
Flashcards
Indirect Adrenergic Receptor Activation
Indirect Adrenergic Receptor Activation
Drugs like amphetamines that indirectly activate adrenergic receptors boost the release of neurotransmitters like norepinephrine and epinephrine.
Non-Catecholamine Advantage
Non-Catecholamine Advantage
Non-catecholamine agents, unlike endogenous catecholamines, aren't broken down by COMT and MAO, giving them a longer lasting effect.
Noradrenaline Affinity
Noradrenaline Affinity
Noradrenaline has a strong preference for binding to α1 adrenergic receptors, triggering specific responses.
Endogenous Catecholamine Limitation
Endogenous Catecholamine Limitation
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Non-Selective Adrenergic Agonists
Non-Selective Adrenergic Agonists
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Dose-Dependent Dopamine Activity
Dose-Dependent Dopamine Activity
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Adrenaline in Anaphylactic Shock
Adrenaline in Anaphylactic Shock
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Emergency Adrenaline Use
Emergency Adrenaline Use
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Adrenaline's Vasoconstrictor Effect
Adrenaline's Vasoconstrictor Effect
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Pseudoephedrine's Action
Pseudoephedrine's Action
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Selective α-Receptor Agonists
Selective α-Receptor Agonists
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Selective α-Agonists' Purpose
Selective α-Agonists' Purpose
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Clinical Uses of Selective α-Agonists
Clinical Uses of Selective α-Agonists
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Non-selective Adrenergic Agonists
Non-selective Adrenergic Agonists
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Adrenaline's Rapid Metabolism
Adrenaline's Rapid Metabolism
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Noradrenaline for Septic Shock
Noradrenaline for Septic Shock
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Study Notes
Indirect Activation of Adrenergic Receptors
- Indirectly activated adrenergic receptors increase the release of endogenous catecholamine, which is done by a type of drug called amphetamines.
Advantage of Non-Catecholamine Agents
- Non-catecholamine agents have an advantage over endogenous catecholamines as they are not metabolized by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO).
Noradrenaline Affinity
- Noradrenaline has a strong affinity to α1 adrenergic receptors.
Limitation of Endogenous Catecholamines
- The primary factor that limits the systemic use of endogenous catecholamines like adrenaline is their rapid metabolism and short duration of action.
Drugs Acting on All Adrenergic Receptors
- Drugs that act on all types of adrenergic receptors, including α1, α2, β1, β2, and β3, are called non-selective adrenergic agonists.
Dose-Dependent Activity of Dopamine
- Dopamine has a dose-dependent activity on α1, β1, and D1 receptors.
Adrenaline in Shock Treatment
- Adrenaline is used to treat anaphylactic shock by reversing the hypotension and bronchoconstriction caused by histamine.
- Adrenaline acts on β2 receptors to reverse the hypotension and bronchoconstriction caused by histamine in anaphylactic shock.
- Noradrenaline is the preferred agent in septic shock.
Emergency Use of Adrenaline
- Adrenaline can be given intramuscularly for anaphylactic shock or cardiac arrest.
Vasoconstrictor Effect of Adrenaline
- When locally administered for its vasoconstrictor effect, adrenaline decreases bleeding and prolongs the duration of action of local anesthetics.
Pseudoephedrine
- Pseudoephedrine increases the release of noradrenaline from synaptic vesicles and can be used orally for its decongestant effect in case of common cold.
- Pseudoephedrine should be used cautiously in hypertensive patients due to its vasoconstrictor effect.
Selective α-Receptor Agonists
- Selective α-receptor agonists help to avoid tachycardia and increase in blood pressure.
- The main reason for using selective α-receptor agonists is to promote vasoconstriction and increase blood pressure.
- The main scope of clinical uses of selective α-receptor agonists is in the treatment of hypotension and nasal congestion.
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Description
This quiz covers the pharmacological actions of sympathomimetic drugs, including their direct and indirect activation of adrenergic receptors. It also explores how these actions impact different body systems based on the type of receptors they act upon.
