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Questions and Answers

Which equation is used to determine the physiologic dead space?

  • Bohr equation (correct)
  • Charles's Law
  • Boyle's Law
  • Dalton's Law

What does an increased arterial-alveolar CO2 difference suggest?

  • Normal lung function
  • Decreased physiological dead space
  • Increased ventilation-perfusion mismatch (correct)
  • Overperfusion of alveoli

Intrapulmonary shunting refers to:

  • Efficient oxygen exchange in the lungs
  • Enhanced ventilation without perfusion
  • Exchange of gases at the alveolar level
  • Blood perfusion without ventilation in alveoli (correct)

Which of the following contributes to anatomic shunts?

<p>Systemic venous blood entering the left ventricle directly (A)</p> Signup and view all the answers

What does the shunt equation divide all alveolar-capillary units into?

<p>Well-matched and poorly-matched V/Q units (B)</p> Signup and view all the answers

How does a shunt-like state differ from anatomic shunts?

<p>A shunt-like state involves impaired ventilation with excess perfusion (A)</p> Signup and view all the answers

What contributes to normal physiologic shunts?

<p>Venous blood that bypasses pulmonary capillaries (C)</p> Signup and view all the answers

What does an absolute intrapulmonary shunt refer to?

<p>'True shunts' where venous blood perfuses unventilated alveoli (C)</p> Signup and view all the answers

What is the primary purpose of the shunt equation in the context of ventilation-perfusion ratios?

<p>To quantify the extent of venous admixture (B)</p> Signup and view all the answers

Which of the following statements best describes the concept of physiologic dead space?

<p>It represents alveoli that are well-ventilated but not perfused (A)</p> Signup and view all the answers

How is the Bohr equation relevant to the understanding of ventilation-perfusion ratios?

<p>It describes the relationship between CO2 elimination and alveolar ventilation (D)</p> Signup and view all the answers

Why is venous admixture a concern when analyzing ventilation-perfusion ratios?

<p>It results in a decrease in arterial oxygen content (A)</p> Signup and view all the answers

Which scenario best describes a ventilation-perfusion mismatch?

<p>Alveoli with high ventilation and low perfusion (A)</p> Signup and view all the answers

When considering regional differences in ventilation-perfusion ratios, what effect does gravity have on V/Q matching?

<p>Gravity causes higher V/Q ratios at the lung bases (C)</p> Signup and view all the answers

Which statement accurately reflects the consequence of a significant shunt in the lungs?

<p>'Left-to-right' intrapulmonary shunting of blood (C)</p> Signup and view all the answers

In the context of venous admixture, what accurately describes 'Bohr effect'?

<p>'Bohr effect' causes a right shift in the oxyhemoglobin dissociation curve (D)</p> Signup and view all the answers

Which factor plays a key role in maintaining gas exchange by bringing O2 into the lungs and removing CO2?

<p>Alveolar ventilation (A)</p> Signup and view all the answers

What is a common influence on mixed venous blood that brings CO2 into the lungs and takes up alveolar O2?

<p>Histamine (B)</p> Signup and view all the answers

Which neural regulation factor may lead to an increase in pulmonary vascular resistance and a decrease in distensibility?

<p>Sympathetic innervation (D)</p> Signup and view all the answers

What effect do pulmonary vasoconstrictors have on pulmonary vascular resistance (PVR)?

<p>Increase PVR (A)</p> Signup and view all the answers

Intrinsic autoregulation leading to vasoconstriction is mainly attributed to which phenomenon?

<p>HPV (C)</p> Signup and view all the answers

Which of the following substances contributes to decreased PVR and increased blood volume?

<p>$\text{PGE1}$ and $\text{PGI2}$ (D)</p> Signup and view all the answers

'Bohr equation' is related to which concept in gas exchange physiology?

<p>Venous admixture (D)</p> Signup and view all the answers

'Physiologic dead space' is primarily associated with which aspect of gas exchange?

<p>$\text{Ventilation-perfusion mismatch}$ (A)</p> Signup and view all the answers

What condition results in a V/Q ratio approaching infinity?

<p>Pulmonary embolism (D)</p> Signup and view all the answers

In which scenario would you observe alveolar dead space?

<p>Intrapulmonary shunts causing underventilation (D)</p> Signup and view all the answers

Which condition allows fresh gas to reach alveoli lacking perfusion?

<p>Physiologic dead space (C)</p> Signup and view all the answers

What happens when the ventilation-perfusion ratio (VA/Q) is higher than normal?

<p>PAO2 increases and PACO2 decreases (C)</p> Signup and view all the answers

What is the consequence of a ventilation-perfusion ratio (VA/Q) less than normal?

<p>PAO2 decreases and PACO2 increases (A)</p> Signup and view all the answers

What is a major cause of hypoxemia related to ventilation-perfusion mismatch?

<p>Intrapulmonary shunts causing underventilation (D)</p> Signup and view all the answers

In the context of ventilation-perfusion ratios, what do alveolar dead space and intrapulmonary shunt represent?

<p>Low VA/Q (A)</p> Signup and view all the answers

How do small shunts manifest when measuring PaO2 during FiO2 1.0 (100%)?

<p>Unchanged PaO2 values (B)</p> Signup and view all the answers

What are the consequences of ventilation-perfusion ratios close to 1.0?

<p>Alveolar PO2s around 100 mmHg and PCO2s close to 40 mmHg (B)</p> Signup and view all the answers

Which scenario increases the required minute ventilation for gas exchange according to the text?

<p>Extrapulmonary shunts like CHD/VSD (A)</p> Signup and view all the answers

What occurs when the VA/Q ratio is higher than normal in terms of oxygen and carbon dioxide levels?

<p>Increase in O2 delivery relative to its removal (D)</p> Signup and view all the answers

When does the Bohr equation not respond to an increase in FiO2?

<p>In case of increased A-a O2 difference (B)</p> Signup and view all the answers

Why does intrapulmonary shunt cause hypoxemia?

<p>Alveoli are underventilated (C)</p> Signup and view all the answers

How does a ventilation-perfusion ratio less than normal affect alveolar gases?

<p>Alveolar gases resembling mixed venous blood (D)</p> Signup and view all the answers

In terms of ventilation-perfusion ratios, what happens when the PO2 increases and PCO2 decreases?

<p>A higher than normal VA/Q ratio (A)</p> Signup and view all the answers
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