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Questions and Answers
What is the primary goal of combinatorial synthesis?
What is the primary goal of combinatorial synthesis?
- To produce as many different structures as possible in a short amount of time (correct)
- To determine the structure of a protein and its binding site by X-ray crystallography
- To design molecules that will fit and bind to a protein binding site
- To search for serendipity lead compounds
What is the term used to describe the discovery of lead compounds through chance or unexpected findings?
What is the term used to describe the discovery of lead compounds through chance or unexpected findings?
- Serendipity (correct)
- Molecular modeling
- Database mining
- Combinatorial synthesis
What is the technique used to study a protein binding site and design molecules that will fit and bind to it?
What is the technique used to study a protein binding site and design molecules that will fit and bind to it?
- Combinatorial synthesis
- NMR spectroscopy
- X-ray crystallography
- Molecular modeling (correct)
What is the term used to describe the process of searching for new lead compounds by searching structural databases?
What is the term used to describe the process of searching for new lead compounds by searching structural databases?
What is the term used to describe the identification of a small molecule that binds to a specific region of a protein binding site?
What is the term used to describe the identification of a small molecule that binds to a specific region of a protein binding site?
What is the necessary requirement for carrying out computerized searches of structural databases?
What is the necessary requirement for carrying out computerized searches of structural databases?
What is the primary purpose of lead optimization in drug development?
What is the primary purpose of lead optimization in drug development?
Which phase of drug activity is concerned with the route of administration of the drug?
Which phase of drug activity is concerned with the route of administration of the drug?
What is the characteristic of structurally specific drugs?
What is the characteristic of structurally specific drugs?
What is the primary difference between structurally specific and nonspecific drugs?
What is the primary difference between structurally specific and nonspecific drugs?
What is the ultimate goal of the pharmacodynamic phase of drug activity?
What is the ultimate goal of the pharmacodynamic phase of drug activity?
What is the purpose of linking epitopes together to create a lead compound?
What is the purpose of linking epitopes together to create a lead compound?
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