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Combinatorial Synthesis and Molecular Modeling

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Combinatorial Synthesis and Molecular Modeling

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Questions and Answers

What is the primary goal of combinatorial synthesis?

To produce as many different structures as possible in a short amount of time (correct)

To determine the structure of a protein and its binding site by X-ray crystallography

To design molecules that will fit and bind to a protein binding site

To search for serendipity lead compounds

What is the term used to describe the discovery of lead compounds through chance or unexpected findings?

Serendipity (correct)

Molecular modeling

Database mining

Combinatorial synthesis

What is the technique used to study a protein binding site and design molecules that will fit and bind to it?

Combinatorial synthesis

NMR spectroscopy

X-ray crystallography

Molecular modeling (correct)

What is the term used to describe the process of searching for new lead compounds by searching structural databases?

Database mining Signup and view all the answers

What is the term used to describe the identification of a small molecule that binds to a specific region of a protein binding site?

Epitope Signup and view all the answers

What is the necessary requirement for carrying out computerized searches of structural databases?

Knowledge of the desired pharmacophore Signup and view all the answers

What is the primary purpose of lead optimization in drug development?

To modify the lead compound to interact more effectively and selectively with its target in the body Signup and view all the answers

Which phase of drug activity is concerned with the route of administration of the drug?

Pharmaceutical phase Signup and view all the answers

What is the characteristic of structurally specific drugs?

Their biological action results from their chemical structure adapting to the 3-D structure of receptors Signup and view all the answers

What is the primary difference between structurally specific and nonspecific drugs?

The chemical structure of the molecule Signup and view all the answers

What is the ultimate goal of the pharmacodynamic phase of drug activity?

To increase the target selectivity of the drug Signup and view all the answers

What is the purpose of linking epitopes together to create a lead compound?

To create a lead compound that binds to the whole of the binding site Signup and view all the answers