12 Questions
What is the primary goal of combinatorial synthesis?
To produce as many different structures as possible in a short amount of time
What is the term used to describe the discovery of lead compounds through chance or unexpected findings?
Serendipity
What is the technique used to study a protein binding site and design molecules that will fit and bind to it?
Molecular modeling
What is the term used to describe the process of searching for new lead compounds by searching structural databases?
Database mining
What is the term used to describe the identification of a small molecule that binds to a specific region of a protein binding site?
Epitope
What is the necessary requirement for carrying out computerized searches of structural databases?
Knowledge of the desired pharmacophore
What is the primary purpose of lead optimization in drug development?
To modify the lead compound to interact more effectively and selectively with its target in the body
Which phase of drug activity is concerned with the route of administration of the drug?
Pharmaceutical phase
What is the characteristic of structurally specific drugs?
Their biological action results from their chemical structure adapting to the 3-D structure of receptors
What is the primary difference between structurally specific and nonspecific drugs?
The chemical structure of the molecule
What is the ultimate goal of the pharmacodynamic phase of drug activity?
To increase the target selectivity of the drug
What is the purpose of linking epitopes together to create a lead compound?
To create a lead compound that binds to the whole of the binding site
Learn about combinatorial synthesis, a method aimed at producing diverse structures quickly, and its relation to molecular modeling and computer-aided design in discovering lead compounds. Understand how X-ray crystallography and molecular modeling software are used to study protein binding sites.
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