Drug Development Techniques Quiz

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Which chapter of 'An introduction to medicinal chemistry' would provide information on finding a lead in drug discovery?

Chapter 12

What is the term used for designing a drug to interact with more than one target?

Polypharmacology

What is the main focus of De novo design in drug discovery?

Designing drugs from scratch

What approach involves the use of molecular modeling and structure-based design in drug discovery?

Pharmacophore modeling Signup and view all the answers

What is the advantage of designing a drug to interact with more than one target?

Increased activity dimerising effect Signup and view all the answers

What is a key feature of a hybrid drug in the context of drug design?

It is a combination of two drugs with different properties Signup and view all the answers

In drug discovery, what is the challenge associated with selecting known pharmacophores groups to block targets?

Complexity in modifying compound down to lead activity Signup and view all the answers

What is the disadvantage of designing a drug to interact with more than one target?

Reduced pharmacophore selectivity Signup and view all the answers

What do chimeric drugs incorporate in their design?

Structures from existing drugs and new drugs Signup and view all the answers

What is the main advantage of the approach to start with a narrow range of drugs and modify down to desired targets?

Reduction in the number of drugs to multi-target drug activity Signup and view all the answers

Which technique is NOT mentioned as a method for lead compound synthesis?

Chemical precipitation Signup and view all the answers

What is the estimated cost to bring a successful drug to market?

$800 million Signup and view all the answers

Which technique is used for determining the structure-activity relationship (SAR) of lead compounds?

X-ray crystallography Signup and view all the answers

What is the primary aim of drug design?

To optimize pharmacodynamic and pharmacokinetic properties Signup and view all the answers

What aspect of the molecule do structure-activity relationship (SAR) studies help identify?

Essential activity and modifiable parts Signup and view all the answers

At what stage does a potential drug candidate begin the process of drug development?

After lead discovery Signup and view all the answers

What is the primary focus of lectures on Drug Discovery in MPharm?

Molecular and physiological understanding of disease and infection Signup and view all the answers

What does the future of drug discovery involve continuing to understand?

Disease and infection at molecular and physiological levels Signup and view all the answers

What is the original use of Buproprion?

To help patients stop smoking Signup and view all the answers

What are the two primary sources of lead compounds for drug discovery mentioned in the text?

Natural sources and enzyme substrates/products Signup and view all the answers

What is the time frame typically required from discovery to approval for a successful drug?

10-15 years Signup and view all the answers

What is included in the combinatorial process of drug discovery?

Identification, synthesis, characterization, screening, and assays for therapeutic efficacy of potential drug candidates Signup and view all the answers

Which of the following is NOT covered in MSOP1016: Drug Discovery?

Major organic reactions and synthetic methodologies Signup and view all the answers

What concept is covered in MSOP1004: Underpinning Chemistry?

Key concepts in organic chemistry, analytical chemistry, and physical chemistry Signup and view all the answers

What does Drug Delivery & Diagnostics cover in MSOP1016?

Challenges and benefits associated with drug delivery Signup and view all the answers

Which area is NOT included in the topics covered by MSOP1016?

History of Modern Medicine Signup and view all the answers

What is the focus of Separation Science in MSOP1016?

Chromatography and non-covalent interactions Signup and view all the answers

What does Drug Discovery primarily cover?

Choosing a disease and a drug target Signup and view all the answers

What is included in the sources of compounds for drug discovery?

Existing drugs and their development Signup and view all the answers

What does Targeted Diagnostics involve?

Early diagnostics and treatment monitoring Signup and view all the answers

'Finding a lead compound' mainly involves which process?

Compound screening and lead compound identification Signup and view all the answers

Which approach does not rely on compound libraries for drug discovery?

Ethnopharmacology Signup and view all the answers

Why may the modern combinatorial approach to drug discovery not completely replace the need for new drug leads from natural sources?

It relies solely on compound libraries, limiting chemical diversity Signup and view all the answers

What is the role of medicinal chemists in the drug discovery process?

To design drugs based on the 3D nature of the molecule and the receptor Signup and view all the answers

What approach can be employed to identify new drug leads from natural sources?

Ethnopharmacology Signup and view all the answers

Why are new chemical entities (NCE) as drugs still necessary for drug discovery?

To meet unmet clinical needs such as anti-virals, antibiotics, and anti-cancers Signup and view all the answers

How can molecular modelling be used in drug discovery?

To study different compounds which react with target proteins Signup and view all the answers

Why is pharmaceutical industry trending towards more risk-averse target selection?

To reduce the rate of new therapeutic discoveries Signup and view all the answers

What can be employed to design drugs based on the binding site and ligand interactions?

Molecular modelling Signup and view all the answers

How can a controlled approach to targeting multiple diseases using a cocktail of drugs benefit drug discovery?

It reduces the number of treatments required for multiple diseases Signup and view all the answers

What is an effective way to discover drug leads according to the text?

Using crystallography and molecular modelling to identify the binding site and optimize the lead compound. Signup and view all the answers

Study Notes

Modern combinatorial approach to drug discovery may not completely replace the need for new drug leads from natural sources due to unmet clinical needs such as anti-virals, antibiotics, and anti-cancers.
Combinatorial chemistry relies on compound libraries, which only sample a part of the chemical diversity present in nature.
Pharmaceutical companies are sharing their compound libraries to increase drug discovery efficiency.
New chemical entities (NCE) as drugs are still necessary for drug discovery.
Medicinal chemists play a crucial role in the drug discovery process by utilizing their skills to design drugs based on the 3D nature of the molecule and the receptor.
Natural drug leads offer a higher diversity of chemical compounds and more rigid compounds, which are more specific.
Combinatorial approaches introduce more non-rigid bonds, lowering the specificity and making leads less effective.
Drug discovery is a lengthy process with a low rate of new therapeutic discoveries.
New targets as opposed to established targets are more prone to drug discovery project failure.
The pharmaceutical industry is trending towards more risk-averse target selection.
Combinatorial approaches have provided effective ways to discover drug leads.
An abundance of natural organisms have not been screened for potentially new leads.
Ethnopharmacology and bioprospecting can be used to identify new drug leads from natural sources.
Structure-based design and molecular modelling can be employed to design drugs based on the binding site and ligand interactions.
Molecular modelling can be used to study different compounds which react with target proteins.
Comparison of compounds can identify a suitable lead compound.
De Novo drug design is a novel approach to designing drugs based on the structure of the target.
Crystallography and molecular modelling can be used to identify the binding site and optimize the lead compound.
Molecular modelling can help identify potential binding regions in the binding site.
Molecular modelling can be used to study membrane-bound proteins.
Alternative approaches such as identifying similar proteins with known crystal structures and designing drugs for the target protein can be employed.
Molecular modelling can help identify synergistic effects and modifications that improve drug activity.
A controlled approach to targeting multiple diseases using a cocktail of drugs can reduce the number of treatments required.

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