Podcast
Questions and Answers
Which chapter of 'An introduction to medicinal chemistry' would provide information on finding a lead in drug discovery?
Which chapter of 'An introduction to medicinal chemistry' would provide information on finding a lead in drug discovery?
- Chapter 11
- Chapter 13
- Chapter 12 (correct)
- Chapter 14
What is the term used for designing a drug to interact with more than one target?
What is the term used for designing a drug to interact with more than one target?
- Pharmacogenomics
- Polypharmacology (correct)
- Drug synergy
- Monotherapy
What is the main focus of De novo design in drug discovery?
What is the main focus of De novo design in drug discovery?
- Designing drugs from scratch (correct)
- Optimizing drug-target interactions
- Finding lead compounds from natural sources
- Modifying existing drugs
What approach involves the use of molecular modeling and structure-based design in drug discovery?
What approach involves the use of molecular modeling and structure-based design in drug discovery?
What is the advantage of designing a drug to interact with more than one target?
What is the advantage of designing a drug to interact with more than one target?
What is a key feature of a hybrid drug in the context of drug design?
What is a key feature of a hybrid drug in the context of drug design?
In drug discovery, what is the challenge associated with selecting known pharmacophores groups to block targets?
In drug discovery, what is the challenge associated with selecting known pharmacophores groups to block targets?
What is the disadvantage of designing a drug to interact with more than one target?
What is the disadvantage of designing a drug to interact with more than one target?
What do chimeric drugs incorporate in their design?
What do chimeric drugs incorporate in their design?
What is the main advantage of the approach to start with a narrow range of drugs and modify down to desired targets?
What is the main advantage of the approach to start with a narrow range of drugs and modify down to desired targets?
Which technique is NOT mentioned as a method for lead compound synthesis?
Which technique is NOT mentioned as a method for lead compound synthesis?
What is the estimated cost to bring a successful drug to market?
What is the estimated cost to bring a successful drug to market?
Which technique is used for determining the structure-activity relationship (SAR) of lead compounds?
Which technique is used for determining the structure-activity relationship (SAR) of lead compounds?
What is the primary aim of drug design?
What is the primary aim of drug design?
What aspect of the molecule do structure-activity relationship (SAR) studies help identify?
What aspect of the molecule do structure-activity relationship (SAR) studies help identify?
At what stage does a potential drug candidate begin the process of drug development?
At what stage does a potential drug candidate begin the process of drug development?
What is the primary focus of lectures on Drug Discovery in MPharm?
What is the primary focus of lectures on Drug Discovery in MPharm?
What does the future of drug discovery involve continuing to understand?
What does the future of drug discovery involve continuing to understand?
What is the original use of Buproprion?
What is the original use of Buproprion?
What are the two primary sources of lead compounds for drug discovery mentioned in the text?
What are the two primary sources of lead compounds for drug discovery mentioned in the text?
What is the time frame typically required from discovery to approval for a successful drug?
What is the time frame typically required from discovery to approval for a successful drug?
What is included in the combinatorial process of drug discovery?
What is included in the combinatorial process of drug discovery?
Which of the following is NOT covered in MSOP1016: Drug Discovery?
Which of the following is NOT covered in MSOP1016: Drug Discovery?
What concept is covered in MSOP1004: Underpinning Chemistry?
What concept is covered in MSOP1004: Underpinning Chemistry?
What does Drug Delivery & Diagnostics cover in MSOP1016?
What does Drug Delivery & Diagnostics cover in MSOP1016?
Which area is NOT included in the topics covered by MSOP1016?
Which area is NOT included in the topics covered by MSOP1016?
What is the focus of Separation Science in MSOP1016?
What is the focus of Separation Science in MSOP1016?
What does Drug Discovery primarily cover?
What does Drug Discovery primarily cover?
What is included in the sources of compounds for drug discovery?
What is included in the sources of compounds for drug discovery?
What does Targeted Diagnostics involve?
What does Targeted Diagnostics involve?
'Finding a lead compound' mainly involves which process?
'Finding a lead compound' mainly involves which process?
Which approach does not rely on compound libraries for drug discovery?
Which approach does not rely on compound libraries for drug discovery?
Why may the modern combinatorial approach to drug discovery not completely replace the need for new drug leads from natural sources?
Why may the modern combinatorial approach to drug discovery not completely replace the need for new drug leads from natural sources?
What is the role of medicinal chemists in the drug discovery process?
What is the role of medicinal chemists in the drug discovery process?
What approach can be employed to identify new drug leads from natural sources?
What approach can be employed to identify new drug leads from natural sources?
Why are new chemical entities (NCE) as drugs still necessary for drug discovery?
Why are new chemical entities (NCE) as drugs still necessary for drug discovery?
How can molecular modelling be used in drug discovery?
How can molecular modelling be used in drug discovery?
Why is pharmaceutical industry trending towards more risk-averse target selection?
Why is pharmaceutical industry trending towards more risk-averse target selection?
What can be employed to design drugs based on the binding site and ligand interactions?
What can be employed to design drugs based on the binding site and ligand interactions?
How can a controlled approach to targeting multiple diseases using a cocktail of drugs benefit drug discovery?
How can a controlled approach to targeting multiple diseases using a cocktail of drugs benefit drug discovery?
What is an effective way to discover drug leads according to the text?
What is an effective way to discover drug leads according to the text?
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Study Notes
- Modern combinatorial approach to drug discovery may not completely replace the need for new drug leads from natural sources due to unmet clinical needs such as anti-virals, antibiotics, and anti-cancers.
- Combinatorial chemistry relies on compound libraries, which only sample a part of the chemical diversity present in nature.
- Pharmaceutical companies are sharing their compound libraries to increase drug discovery efficiency.
- New chemical entities (NCE) as drugs are still necessary for drug discovery.
- Medicinal chemists play a crucial role in the drug discovery process by utilizing their skills to design drugs based on the 3D nature of the molecule and the receptor.
- Natural drug leads offer a higher diversity of chemical compounds and more rigid compounds, which are more specific.
- Combinatorial approaches introduce more non-rigid bonds, lowering the specificity and making leads less effective.
- Drug discovery is a lengthy process with a low rate of new therapeutic discoveries.
- New targets as opposed to established targets are more prone to drug discovery project failure.
- The pharmaceutical industry is trending towards more risk-averse target selection.
- Combinatorial approaches have provided effective ways to discover drug leads.
- An abundance of natural organisms have not been screened for potentially new leads.
- Ethnopharmacology and bioprospecting can be used to identify new drug leads from natural sources.
- Structure-based design and molecular modelling can be employed to design drugs based on the binding site and ligand interactions.
- Molecular modelling can be used to study different compounds which react with target proteins.
- Comparison of compounds can identify a suitable lead compound.
- De Novo drug design is a novel approach to designing drugs based on the structure of the target.
- Crystallography and molecular modelling can be used to identify the binding site and optimize the lead compound.
- Molecular modelling can help identify potential binding regions in the binding site.
- Molecular modelling can be used to study membrane-bound proteins.
- Alternative approaches such as identifying similar proteins with known crystal structures and designing drugs for the target protein can be employed.
- Molecular modelling can help identify synergistic effects and modifications that improve drug activity.
- A controlled approach to targeting multiple diseases using a cocktail of drugs can reduce the number of treatments required.
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