Combinatorial Chemistry: Innovative Approach in Chemistry
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Questions and Answers

What is the primary purpose of combinatorial chemistry in medicinal chemistry projects?

  • To identify a lead compound for further modification
  • To synthesize a single compound in a stepwise-directed manner
  • To establish the molecular target and mechanism of action for a drug
  • To create a large population of structurally different molecules for high throughput screening (correct)

    • What revolutionized the priorities in medicinal chemistry projects, leading to the emphasis on discovering a lead compound that will interact with an identifiable target?

  • The orthodox synthesis method
  • The solid-phase technique
  • The human genome project and the proteomic revolution (correct)
  • The mix and split technique

    • What are the advantages of using solid-phase techniques in combinatorial chemistry?

  • Faster and more efficient synthesis
  • Use of large excesses of reagents to drive reactions to completion
  • Easy removal of excess reagents and by-products (correct)
  • Formation of millions of compounds simultaneously in mixtures

    • What was the first successful example of solid phase synthesis in combinatorial chemistry?

    <p>Merrifield resin peptide synthesis</p> Signup and view all the answers

    Which technique involves carrying out reactions where the starting material is linked to a solid support, such as a resin bead, and then detaching the final structure from the solid support?

    <p>Solid-phase technique</p> Signup and view all the answers

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