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What is the primary purpose of combinatorial chemistry in medicinal chemistry projects?
What is the primary purpose of combinatorial chemistry in medicinal chemistry projects?
- To identify a lead compound for further modification
- To synthesize a single compound in a stepwise-directed manner
- To establish the molecular target and mechanism of action for a drug
- To create a large population of structurally different molecules for high throughput screening (correct)
What revolutionized the priorities in medicinal chemistry projects, leading to the emphasis on discovering a lead compound that will interact with an identifiable target?
What revolutionized the priorities in medicinal chemistry projects, leading to the emphasis on discovering a lead compound that will interact with an identifiable target?
- The orthodox synthesis method
- The solid-phase technique
- The human genome project and the proteomic revolution (correct)
- The mix and split technique
What are the advantages of using solid-phase techniques in combinatorial chemistry?
What are the advantages of using solid-phase techniques in combinatorial chemistry?
- Faster and more efficient synthesis
- Use of large excesses of reagents to drive reactions to completion
- Easy removal of excess reagents and by-products (correct)
- Formation of millions of compounds simultaneously in mixtures
What was the first successful example of solid phase synthesis in combinatorial chemistry?
What was the first successful example of solid phase synthesis in combinatorial chemistry?
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Which technique involves carrying out reactions where the starting material is linked to a solid support, such as a resin bead, and then detaching the final structure from the solid support?
Which technique involves carrying out reactions where the starting material is linked to a solid support, such as a resin bead, and then detaching the final structure from the solid support?
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