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Questions and Answers
In combinatorial chemistry, why has there been much interest in using solution-phase chemistry for the preparation of combinatorial libraries?
In combinatorial chemistry, why has there been much interest in using solution-phase chemistry for the preparation of combinatorial libraries?
- To avoid mixtures of products that occur in one-bead synthesis
- To reduce the time and resources required to develop and optimize reaction conditions for solid support reactions (correct)
- To increase the yield of reactions that cannot be run on solid supports
- To ensure that all reactions occur between amines and acid chlorides
What is the advantage of one-bead synthesis over solution-phase combinatorial chemistry?
What is the advantage of one-bead synthesis over solution-phase combinatorial chemistry?
- One-bead synthesis results in one-compound synthesis (correct)
- One-bead synthesis results in a mixture of products
- One-bead synthesis allows for reactions between amines and chlorides only
- One-bead synthesis is more time-consuming than solution-phase combinatorial chemistry
Why are many reactions unable to be run on solid supports in combinatorial chemistry?
Why are many reactions unable to be run on solid supports in combinatorial chemistry?
- Due to the lack of interest in solid support reactions
- Because it takes time and resources to develop and optimize reaction conditions for solid support reactions
- Because solid support reactions result in poor yields (correct)
- Because solid support reactions lead to a mixture of products
What is the outcome of reacting a set of 10 amines with 10 acid chlorides in one flask, using the chosen reactants and conditions?
What is the outcome of reacting a set of 10 amines with 10 acid chlorides in one flask, using the chosen reactants and conditions?
Why does solution-phase combinatorial chemistry often lead to a mixture of products?
Why does solution-phase combinatorial chemistry often lead to a mixture of products?
What is the major limitation of running reactions on solid supports in combinatorial chemistry?
What is the major limitation of running reactions on solid supports in combinatorial chemistry?
What is the main difference between solid-phase chemistry and solution-phase chemistry?
What is the main difference between solid-phase chemistry and solution-phase chemistry?
Which type of soluble polymer can be liquid or solid at room temperature, depending on the degree of polymerization?
Which type of soluble polymer can be liquid or solid at room temperature, depending on the degree of polymerization?
What is the main function of terminal amino groups in dendrimers?
What is the main function of terminal amino groups in dendrimers?
What is the composition of fluorous phases used as a soluble support for synthesis?
What is the composition of fluorous phases used as a soluble support for synthesis?
How do researchers at Harvard use complementary DNA in synthesis?
How do researchers at Harvard use complementary DNA in synthesis?
What is the purpose of recursive deconvolution in identifying the active component in a mixture?
What is the purpose of recursive deconvolution in identifying the active component in a mixture?
What is the purpose of tagging in combinatorial synthesis?
What is the purpose of tagging in combinatorial synthesis?
What is the main challenge associated with purification in mixture-based experiments?
What is the main challenge associated with purification in mixture-based experiments?
What are the yields of products often found to be in mixture-based experiments?
What are the yields of products often found to be in mixture-based experiments?
What can be tested to eventually find the structure(s) responsible for activity?
What can be tested to eventually find the structure(s) responsible for activity?
In combinatorial chemistry, what is the main challenge associated with using solution-phase chemistry for the preparation of combinatorial libraries?
In combinatorial chemistry, what is the main challenge associated with using solution-phase chemistry for the preparation of combinatorial libraries?
What is the major limitation of running reactions on solid supports in combinatorial chemistry?
What is the major limitation of running reactions on solid supports in combinatorial chemistry?
What is the purpose of recursive deconvolution in identifying the active component in a mixture?
What is the purpose of recursive deconvolution in identifying the active component in a mixture?
Why are many reactions unable to be run on solid supports in combinatorial chemistry?
Why are many reactions unable to be run on solid supports in combinatorial chemistry?
What can be tested to eventually find the structure(s) responsible for activity in combinatorial chemistry?
What can be tested to eventually find the structure(s) responsible for activity in combinatorial chemistry?
What is the main difference between solid-phase chemistry and solution-phase chemistry in combinatorial chemistry?
What is the main difference between solid-phase chemistry and solution-phase chemistry in combinatorial chemistry?
What is the primary purpose of using soluble polymers as a support in solution-phase chemistry?
What is the primary purpose of using soluble polymers as a support in solution-phase chemistry?
What is the main function of terminal amino groups in dendrimers?
What is the main function of terminal amino groups in dendrimers?
What is the composition of fluorous phases used as a soluble support for synthesis?
What is the composition of fluorous phases used as a soluble support for synthesis?
What is the main challenge associated with purification in mixture-based experiments?
What is the main challenge associated with purification in mixture-based experiments?
What is the primary purpose of recursive deconvolution in identifying the active component in a mixture?
What is the primary purpose of recursive deconvolution in identifying the active component in a mixture?
What is the advantage of one-bead synthesis over solution-phase combinatorial chemistry?
What is the advantage of one-bead synthesis over solution-phase combinatorial chemistry?
Why has there been much interest in using solution-phase chemistry for the preparation of combinatorial libraries?
Why has there been much interest in using solution-phase chemistry for the preparation of combinatorial libraries?
What can be tested to eventually find the structure(s) responsible for activity?
What can be tested to eventually find the structure(s) responsible for activity?
How do Harvard researchers use complementary DNA in synthesis?
How do Harvard researchers use complementary DNA in synthesis?
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