29 Questions
What is the primary focus of combinatorial chemistry?
Synthesizing a large number of structurally distinct molecules
In classical approach, how were compounds typically synthesized?
One at a time in a serial fashion
What was the limitation of the classical approach in terms of the number of structures synthesized?
Only a handful of structures could be synthesized
In combinatorial chemistry, what is the purpose of performing pharmacological assays?
To evaluate the activity of the synthesized molecules
What distinguishes combinatorial chemistry from the classical approach?
Ability to synthesize large numbers of structurally distinct molecules
Which approach involves making changes on an existing compound or synthesizing a new structure and evaluating its effects?
Classical approach
What is the basic principle of combinatorial chemistry?
To prepare a chemical library of a very large number of synthetic compounds
What is the purpose of high-throughput screening (HTS) in combinatorial chemistry?
To perform in vitro assays of new compounds after synthesis
What are the two common types of chemical libraries used in combinatorial chemistry?
Generic library and mixture library
What is the purpose of synthesizing and screening thousands of structures in drug development?
To find new lead compounds and identify structure-activity relationships
What is the role of a lead compound in pharmaceutical chemistry?
To start with a lead compound and make and test related compounds
What is the main advantage of combinatorial chemistry in drug discovery?
Rapidly synthesizes and screens thousands of structures
What distinguishes the two common types of chemical libraries used in combinatorial chemistry?
Number of substituents and the total number of structures
What does high-throughput screening (HTS) provide in the field of drug discovery?
The most promising substances for drug discovery
Why is it important for pharmaceutical chemists to start with a lead compound?
To identify analogues with good activity and minimal side effects
What is the primary purpose of chemical libraries in combinatorial chemistry?
To be screened for drug activity after synthesis
In combinatorial chemistry, what is the primary goal of synthesizing a large number of structurally distinct molecules?
To increase the likelihood of finding molecules with desired pharmacological properties
What distinguishes combinatorial chemistry from the classical approach in terms of compound synthesis?
Combinatorial chemistry involves synthesizing multiple structurally distinct molecules simultaneously
What is the primary advantage of combinatorial chemistry in drug development?
It allows for high-throughput screening (HTS) of compounds
What role do biological assays play in the classical approach to compound synthesis?
They are used to perform in vitro assays of new compounds after synthesis
What is the purpose of performing high-throughput screening (HTS) in combinatorial chemistry?
To evaluate the pharmacological properties of newly synthesized molecules
What distinguishes the two common types of chemical libraries used in combinatorial chemistry?
Their capability to produce large numbers of structurally distinct molecules
What is the primary focus of high-throughput screening (HTS) in the field of drug discovery?
To perform in vitro assays of new compounds after synthesis
What distinguishes the two common types of chemical libraries used in combinatorial chemistry?
Mixture library contains a variety of structure types, while generic library is based on a single parent structure
What is the main advantage of combinatorial chemistry in drug discovery?
Allows for the rapid synthesis and screening of thousands of structures
What is the purpose of chemical libraries in combinatorial chemistry?
To prepare chemical library of a very large number of synthetic compounds
What distinguishes combinatorial chemistry from the classical approach in drug discovery?
Combinatorial chemistry involves making changes on an existing compound or synthesizing a new structure, while classical approach involves random synthesis
What is the role of a lead compound in pharmaceutical chemistry?
To make and test compounds with structures closely related to it
Why is it important for pharmaceutical chemists to start with a lead compound?
To have a starting point for making and testing structurally related compounds
Test your knowledge of combinatorial chemistry in drug design with this quiz covering topics such as classical approach, combinatorial chemistry approach, and computer aided drug design.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
