PhLE Module 1: Pharmaceutical Chemistry and General Chemistry
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Questions and Answers

What is the state of matter characterized by having p+ and e-, and is greatly affected by magnetic fields?

  • Solid
  • Gas
  • Liquid
  • Plasma (correct)
  • Which of the following properties is independent of the amount of matter present?

  • Mass
  • Volume
  • Entropy
  • Density (correct)
  • What is the process by which a solid changes directly into a gas?

  • Ionization
  • Deposition
  • Recombination
  • Sublimation (correct)
  • Which of the following is an example of a homogeneous mixture?

    <p>Solution</p> Signup and view all the answers

    What is the strength of intermolecular forces in the order of strongest to weakest?

    <p>S &gt; L &gt; G &gt; P</p> Signup and view all the answers

    Which law is related to the study of the fundamental properties of matter?

    <p>Fundamental Chemistry Laws</p> Signup and view all the answers

    What is the condition for spontaneity in a thermodynamic process?

    <p>ΔG &lt; 0</p> Signup and view all the answers

    Which law states that energy cannot be created or destroyed, only transformed from one form to another?

    <p>First Law of Thermodynamics</p> Signup and view all the answers

    What is the change in enthalpy (ΔH) a measure of?

    <p>The heat or reaction energy of a system</p> Signup and view all the answers

    What is the significance of the entropy of a perfect, solid, crystalline substance at absolute zero temperature?

    <p>It is zero</p> Signup and view all the answers

    What is the study of reaction rates and mechanisms called?

    <p>Chemical Kinetics</p> Signup and view all the answers

    What is the relationship between the rate of reaction and the rate constant (K) expressed in?

    <p>Rate Law</p> Signup and view all the answers

    What is the characteristic of symmetrical ethers?

    <p>Same R groups on both sides of the ether oxygen</p> Signup and view all the answers

    What is the product of the oxidation of a secondary alcohol?

    <p>Ketone</p> Signup and view all the answers

    What is the characteristic of epoxides?

    <p>Oxygen is part of a 3-membered ring system</p> Signup and view all the answers

    What is the IUPAC nomenclature rule for aldehydes?

    <p>Change -e to -al</p> Signup and view all the answers

    What is a requirement for a compound to exhibit optical activity?

    <p>It must have a stereocenter.</p> Signup and view all the answers

    What is the test for methyl ketones?

    <p>Iodoform Test (+)</p> Signup and view all the answers

    What is the term for a species with a positively charged carbon atom?

    <p>Carbocation</p> Signup and view all the answers

    What is the purpose of adding methanol to ethanol to make it unfit for human consumption?

    <p>To make ethanol undrinkable</p> Signup and view all the answers

    What is the product of catalytic hydrogenation of alkynes using Lindlar's catalyst?

    <p>Cis-alkene</p> Signup and view all the answers

    What is the reagent used in Friedel-Craft's acylation?

    <p>CH3COCl</p> Signup and view all the answers

    What is the result of hydrating a terminal alkyne?

    <p>Production of a methyl ketone</p> Signup and view all the answers

    What is the use of phenol, also known as carbolic acid?

    <p>As a disinfectant for surgical instruments</p> Signup and view all the answers

    What is the requirement for a compound to be considered aromatic?

    <p>Cyclic, planar, and sp2 hybridization</p> Signup and view all the answers

    What is the primary use of isopropyl alcohol?

    <p>As a component of rubbing alcohol</p> Signup and view all the answers

    What is the type of reaction that occurs in the nitration of benzene?

    <p>Electrophilic aromatic substitution</p> Signup and view all the answers

    What is glycerol used in the manufacture of?

    <p>Certain plastics</p> Signup and view all the answers

    What is the rule for determining the aromaticity of a compound?

    <p>4n + 2</p> Signup and view all the answers

    Study Notes

    Matter

    • Matter can exist in three states: solid, liquid, and gas
    • Sublimation is the transition from solid to gas, and deposition is the reverse process
    • Recombination and deionization can occur in plasma
    • Shape and volume of matter can be definite or indefinite
    • Molecular motion is a key characteristic of matter

    Plasma

    • Plasma is the fourth state of matter, most abundant in the universe
    • Has positively charged ions (p+) and negatively charged electrons (e-), affected by magnetic fields
    • Examples: ionized neon light, aurora, stars, and sun

    Classification of Matter

    • Pure substance: a sample of matter with constant composition and properties
    • Mixture: a physical combination of two or more substances, separated by physical means
    • Element: the simplest form of a substance, cannot be broken down further
    • Compound: a substance composed of two or more different elements, combined through chemical means

    Phase Changes

    • Change in state from solid to gas is sublimation
    • Change in state from gas to solid is deposition
    • Change in state from solid to liquid is melting
    • Change in state from liquid to gas is vaporization

    Thermodynamics

    • Zeroth Law of Thermodynamics: two systems in thermal equilibrium with a third system are also in thermal equilibrium with each other
    • First Law of Thermodynamics: energy is conserved, not created or destroyed, but can be transformed from one form to another
    • Second Law of Thermodynamics: entropy of an isolated system always increases over time
    • Third Law of Thermodynamics: entropy of a perfect, solid, crystalline substance is zero at absolute zero temperature

    Chemical Kinetics

    • Study of reaction rates and mechanisms
    • Reaction rate: change in concentration of a reactant or product with time
    • Rate law: expresses the relationship of the rate of reaction to the rate constant and concentration of reactants

    Organic Chemistry

    • Ethers: a class of organic compounds with an oxygen atom bonded to two alkyl or aryl groups
    • Aldehydes and ketones: classes of organic compounds with a carbonyl functional group
    • Chirality: the existence of non-superimposable mirror images of a molecule
    • Stereochemistry: the study of the three-dimensional arrangement of atoms in a molecule

    Functional Groups

    • Electrophile: an electron-deficient species that seeks electrons
    • Nucleophile: an electron-rich species that donates electrons
    • Carbocation: a species with a positively charged carbon atom
    • Functional group: a specific group of atoms in a molecule that determines its chemical reactivity

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    Test your knowledge of pharmaceutical chemistry and general chemistry concepts, including matter, mass, volume, states of matter, and molecular motion. Review topics like sublimation, deposition, and ionization, and learn about the classification of matter.

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