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Questions and Answers
What is the main purpose of identifying the number of rotatable bonds in computer-designed libraries?
What is the main purpose of identifying the number of rotatable bonds in computer-designed libraries?
- To rank all possible synthetic products automatically
- To achieve rigidity by determining the number of rotatable bonds (correct)
- To identify the pharmacophore triangles for each conformation
- To identify all possible target structures
What is the impact of comparing the pharmacophores for both structures in the computer-designed libraries?
What is the impact of comparing the pharmacophores for both structures in the computer-designed libraries?
- Eliminating structures that do not contribute significant numbers of new pharmacophores
- Increasing the efficiency in finding lead compounds
- Retaining the first structure if it contains more than 10% new pharmacophores (correct)
- Ranking the possible synthetic products automatically
What is the primary function of computer-designed libraries in combinatorial chemistry?
What is the primary function of computer-designed libraries in combinatorial chemistry?
- To identify all possible target structures
- To eliminate structures that do not contribute significant new pharmacophores (correct)
- To increase efficiency in finding lead compounds
- To identify the number of rotatable bonds for each structure
What is the significance of identifying the pharmacophore triangles for each conformation in combinatorial chemistry?
What is the significance of identifying the pharmacophore triangles for each conformation in combinatorial chemistry?
How does the process of identifying all possible target structures impact efficiency in finding lead compounds?
How does the process of identifying all possible target structures impact efficiency in finding lead compounds?
What is the outcome of adding together both sets of pharmacophores and comparing with the next most rigid structure in computer-designed libraries?
What is the outcome of adding together both sets of pharmacophores and comparing with the next most rigid structure in computer-designed libraries?
What is a major challenge in the detection, analysis, and purification of combinatorial libraries?
What is a major challenge in the detection, analysis, and purification of combinatorial libraries?
Why must the methods used for analysis be suitable for rapid, parallel analysis in the context of combinatorial libraries?
Why must the methods used for analysis be suitable for rapid, parallel analysis in the context of combinatorial libraries?
Which spectroscopic technique is used to identify conjugated systems?
Which spectroscopic technique is used to identify conjugated systems?
What is a unique consideration for IR spectroscopy in combinatorial chemistry?
What is a unique consideration for IR spectroscopy in combinatorial chemistry?
Which spectroscopic technique provides more structural information than IR or UV spectroscopy?
Which spectroscopic technique provides more structural information than IR or UV spectroscopy?
Why are compounds normally cleaved from solid support before analysis by NMR?
Why are compounds normally cleaved from solid support before analysis by NMR?
What is a characteristic of magic angle spinning NMR?
What is a characteristic of magic angle spinning NMR?
What type of interaction does spectroscopy study?
What type of interaction does spectroscopy study?
Which technique can be used to identify the molecular weight and molecular formula of compounds?
Which technique can be used to identify the molecular weight and molecular formula of compounds?
What type of method is needed to enhance very small spectral signals from one or a few beads in IR spectroscopy?
What type of method is needed to enhance very small spectral signals from one or a few beads in IR spectroscopy?
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