Al-Nahrain University Pharmaceutical Chemistry IV Quiz

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What is the main purpose of identifying the number of rotatable bonds in computer-designed libraries?

To rank all possible synthetic products automatically

To achieve rigidity by determining the number of rotatable bonds (correct)

To identify the pharmacophore triangles for each conformation

To identify all possible target structures

What is the impact of comparing the pharmacophores for both structures in the computer-designed libraries?

Eliminating structures that do not contribute significant numbers of new pharmacophores

Increasing the efficiency in finding lead compounds

Retaining the first structure if it contains more than 10% new pharmacophores (correct)

Ranking the possible synthetic products automatically

What is the primary function of computer-designed libraries in combinatorial chemistry?

To identify all possible target structures

To eliminate structures that do not contribute significant new pharmacophores (correct)

To increase efficiency in finding lead compounds

To identify the number of rotatable bonds for each structure

What is the significance of identifying the pharmacophore triangles for each conformation in combinatorial chemistry?

To summarize the groups important in binding a lead compound to its target Signup and view all the answers

How does the process of identifying all possible target structures impact efficiency in finding lead compounds?

Increases efficiency by retaining 90% of possible pharmacophores Signup and view all the answers

What is the outcome of adding together both sets of pharmacophores and comparing with the next most rigid structure in computer-designed libraries?

Retaining the second structure if it contains more than 10% new pharmacophores Signup and view all the answers

What is a major challenge in the detection, analysis, and purification of combinatorial libraries?

The requirement for nondestructive analysis Signup and view all the answers

Why must the methods used for analysis be suitable for rapid, parallel analysis in the context of combinatorial libraries?

To avoid the rate-limiting step in the procedure Signup and view all the answers

Which spectroscopic technique is used to identify conjugated systems?

Ultraviolet/Visible spectroscopy (UV/VIS) Signup and view all the answers

What is a unique consideration for IR spectroscopy in combinatorial chemistry?

Flattened beads give stronger IR signals Signup and view all the answers

Which spectroscopic technique provides more structural information than IR or UV spectroscopy?

Nuclear Magnetic Resonance spectroscopy (NMR) Signup and view all the answers

Why are compounds normally cleaved from solid support before analysis by NMR?

To prevent broadened peaks and low resolution Signup and view all the answers

What is a characteristic of magic angle spinning NMR?

It provides higher resolution than traditional NMR Signup and view all the answers

What type of interaction does spectroscopy study?

Interaction between matter and electromagnetic radiation (EMR) Signup and view all the answers

Which technique can be used to identify the molecular weight and molecular formula of compounds?

Mass Spectrometry (MS) Signup and view all the answers

What type of method is needed to enhance very small spectral signals from one or a few beads in IR spectroscopy?

Fourier transform IR (FTIR) Signup and view all the answers

Al-Nahrain University Pharmaceutical Chemistry IV Quiz

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