Al-Nahrain University Pharmaceutical Chemistry IV Quiz

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Questions and Answers

What is the main purpose of identifying the number of rotatable bonds in computer-designed libraries?

  • To rank all possible synthetic products automatically
  • To achieve rigidity by determining the number of rotatable bonds (correct)
  • To identify the pharmacophore triangles for each conformation
  • To identify all possible target structures

What is the impact of comparing the pharmacophores for both structures in the computer-designed libraries?

  • Eliminating structures that do not contribute significant numbers of new pharmacophores
  • Increasing the efficiency in finding lead compounds
  • Retaining the first structure if it contains more than 10% new pharmacophores (correct)
  • Ranking the possible synthetic products automatically

What is the primary function of computer-designed libraries in combinatorial chemistry?

  • To identify all possible target structures
  • To eliminate structures that do not contribute significant new pharmacophores (correct)
  • To increase efficiency in finding lead compounds
  • To identify the number of rotatable bonds for each structure

What is the significance of identifying the pharmacophore triangles for each conformation in combinatorial chemistry?

<p>To summarize the groups important in binding a lead compound to its target (B)</p> Signup and view all the answers

How does the process of identifying all possible target structures impact efficiency in finding lead compounds?

<p>Increases efficiency by retaining 90% of possible pharmacophores (A)</p> Signup and view all the answers

What is the outcome of adding together both sets of pharmacophores and comparing with the next most rigid structure in computer-designed libraries?

<p>Retaining the second structure if it contains more than 10% new pharmacophores (C)</p> Signup and view all the answers

What is a major challenge in the detection, analysis, and purification of combinatorial libraries?

<p>The requirement for nondestructive analysis (A)</p> Signup and view all the answers

Why must the methods used for analysis be suitable for rapid, parallel analysis in the context of combinatorial libraries?

<p>To avoid the rate-limiting step in the procedure (A)</p> Signup and view all the answers

Which spectroscopic technique is used to identify conjugated systems?

<p>Ultraviolet/Visible spectroscopy (UV/VIS) (B)</p> Signup and view all the answers

What is a unique consideration for IR spectroscopy in combinatorial chemistry?

<p>Flattened beads give stronger IR signals (A)</p> Signup and view all the answers

Which spectroscopic technique provides more structural information than IR or UV spectroscopy?

<p>Nuclear Magnetic Resonance spectroscopy (NMR) (D)</p> Signup and view all the answers

Why are compounds normally cleaved from solid support before analysis by NMR?

<p>To prevent broadened peaks and low resolution (B)</p> Signup and view all the answers

What is a characteristic of magic angle spinning NMR?

<p>It provides higher resolution than traditional NMR (A)</p> Signup and view all the answers

What type of interaction does spectroscopy study?

<p>Interaction between matter and electromagnetic radiation (EMR) (B)</p> Signup and view all the answers

Which technique can be used to identify the molecular weight and molecular formula of compounds?

<p>Mass Spectrometry (MS) (B)</p> Signup and view all the answers

What type of method is needed to enhance very small spectral signals from one or a few beads in IR spectroscopy?

<p>Fourier transform IR (FTIR) (D)</p> Signup and view all the answers

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