Recent

  • Show all results for ""
Coating of Tablets - Objectives and Benefits
37 Questions
1 Views

Coating of Tablets - Objectives and Benefits

Created by
@FascinatingLeaningTowerOfPisa3199

Questions and Answers

What is the primary function of external plasticizers in coating solutions?

  • To increase drying time
  • To impart flexibility and alter properties of films (correct)
  • To act as a solvent
  • To enhance color intensity

    • The choice of plasticizer does not affect the polymer's properties.

    False

    Name one example of an external plasticizer used in coating formulations.

    Castor oil

    The ability of a plasticizer to _____ the polymer is crucial for achieving desired film properties.

    <p>solvate</p> Signup and view all the answers

    Match the following types of colorants with their description:

    <p>Soluble colorants = Dissolves in the solvent system Insoluble powders = Suspended in the coating solution Fine-powdered colorants = Used for proper distribution in solutions Colorants = Provide distinctive color and elegance</p> Signup and view all the answers

    What is one of the primary objectives of coating tablets?

    <p>To mask the taste, odor, and color of the drugs</p> Signup and view all the answers

    Coating does not impact the cost of tablet production.

    <p>False</p> Signup and view all the answers

    Name one reason why tablets should be resistant to abrasion and chipping during the coating process.

    <p>To tolerate the intense attrition of tablets striking each other or the walls of the coating equipment.</p> Signup and view all the answers

    The coating process can help protect drugs from the __________ environment.

    <p>gastric</p> Signup and view all the answers

    Match the coating objective to its description:

    <p>To mask taste = Hides unpleasant flavors or odors To provide protection = Defends against chemical and physical degradation To control release = Regulates the timing of drug release To improve elegance = Enhances the visual appeal of tablets</p> Signup and view all the answers

    Which of the following is NOT a primary component of tablet coating?

    <p>Tablet flavoring agents</p> Signup and view all the answers

    The shape of the tablet is not significant in the coating process.

    <p>False</p> Signup and view all the answers

    What must tablets be protected from during the coating process?

    <p>Chemicals in the coating composition and physical damage</p> Signup and view all the answers

    Which property is NOT mentioned as a characteristic of the ideal polymer for film coating?

    <p>Resistance to temperature changes</p> Signup and view all the answers

    Hydroxypropyl Methylcellulose (HPMC) interacts significantly with colorants.

    <p>False</p> Signup and view all the answers

    What is one of the primary uses of Hydroxypropyl Methylcellulose in film coating?

    <p>To serve as a film former with flexibility and stability.</p> Signup and view all the answers

    Methyl Hydroxyethylcellulose is prepared by reacting alkali-treated cellulose first with _______ and then with ethylene oxide.

    <p>methyl chloride</p> Signup and view all the answers

    Match the following film formers with their characteristics:

    <p>Hydroxypropyl Methylcellulose = Flexibility and noninterference with drug availability Methyl Hydroxyethylcellulose = Prepared with ethylene oxide Both = Commercially available in varying viscosity grades</p> Signup and view all the answers

    What characteristic of a film former helps prevent bridging or filling on debossed tablet surfaces?

    <p>Mixture with other polymers or plasticizers</p> Signup and view all the answers

    Film formers can provide barriers against moisture and light when desired.

    <p>True</p> Signup and view all the answers

    What is a common application for film formers in the pharmaceutical industry?

    <p>To coat tablets and improve stability and appearance.</p> Signup and view all the answers

    Which polymer dissolves only above pH 6 and may delay drug absorption?

    <p>Cellulose Acetate Phthalate</p> Signup and view all the answers

    Eudragit L is soluble in intestinal fluid at a pH of 7.

    <p>True</p> Signup and view all the answers

    What does HPMCP stand for?

    <p>Hydroxypropyl Methylcellulose Phthalate</p> Signup and view all the answers

    Cellulose Acetate Phthalate is known to be _______ in comparison to other enteric polymers.

    <p>hygroscopic</p> Signup and view all the answers

    Match the following enteric materials with their key characteristics:

    <p>Cellulose Acetate Phthalate = Dissolves above pH 6 and hygroscopic Eudragit L = Soluble at pH 6 Eudragit S = Soluble at pH 7 HPMCP = Dissolves at pH 5 to 5.5</p> Signup and view all the answers

    What characteristic of HPMCP may result in higher bioavailability of specific drugs?

    <p>Lower pH solubility</p> Signup and view all the answers

    Most commercially available enteric materials display at least two ideal coating properties.

    <p>False</p> Signup and view all the answers

    Name two types of enteric acrylic resins mentioned.

    <p>Eudragit L and Eudragit S</p> Signup and view all the answers

    What is the average molecular weight of povidone K-30?

    <p>40,000</p> Signup and view all the answers

    Sodium carboxymethylcellulose is soluble in most organic solvents.

    <p>False</p> Signup and view all the answers

    What are the characteristics of dry povidone films?

    <p>Clear, glossy, and hard.</p> Signup and view all the answers

    Sodium carboxymethylcellulose is the sodium salt of __________.

    <p>carboxymethyl-cellulose</p> Signup and view all the answers

    Which of the following is NOT a primary use of povidone?

    <p>Dispersing agent</p> Signup and view all the answers

    Match the following materials with their properties:

    <p>Povidone = Tablet binder and coating Sodium Carboxymethylcellulose = Brittle films that adhere well Polyethylene Glycols = Plasticizers for low molecular weight</p> Signup and view all the answers

    Polyethylene glycols with high molecular weights are liquid at room temperature.

    <p>False</p> Signup and view all the answers

    What happens when sodium carboxymethylcellulose is added to water?

    <p>It forms colloidal solutions.</p> Signup and view all the answers

    Study Notes

    Coating of Tablets: Purpose and Components

    • Coating increases tablet manufacturing costs, yet serves several key purposes.
    • Objectives include:
      • Masking taste, odor, and color of drugs.
      • Providing physical and chemical protection.
      • Controlling drug release from tablets.
      • Protecting drugs from the acidic gastric environment through enteric coating.
      • Preventing chemical incompatibilities in multi-drug formulations.
      • Enhancing pharmaceutical aesthetics with color and printing.

    Primary Components of Tablet Coating

    • Tablet coating involves three main components:
      • Tablet properties.
      • Coating compositions.
      • Coating processes, including equipment and automation.

    Tablet Properties

    • Coated tablets must meet specific physical characteristics to withstand the coating process.
    • Key physical traits include:
      • Resistance to abrasion and chipping.
      • Appropriate physical shape to maintain coating integrity.
      • Compatibility with common additives in the coating solution.
      • Non-toxic and no pharmacologic activity.
      • Resistance to cracking and moisture/light barriers.
      • No bridging or filling of debossed tablet surfaces.
      • Adequate printing capability for high-speed equipment.

    Film Formers: Nonenteric Materials

    • Hydroxypropyl Methylcellulose (HPMC):

      • Ideal due to solubility, stability, flexibility, and non-interference in drug release.
      • Tends to bridge surfaces; often mixed with other polymers to mitigate this issue.

    • Methyl Hydroxyethylcellulose:

      • Clear, glossy films with excellent solubility in various solvents, widely used as a coating agent.

    • Sodium Carboxymethylcellulose:

      • Forms brittle films that adhere well; less suited for organic solvent coatings but useful in aqueous systems.

    • Polyethylene Glycols (PEG):

      • Low molecular weight variants serve as liquid plasticizers; high molecular weight variants provide solid coatings.

    Enteric Coating Materials

    • Cellulose Acetate Phthalate (CAP):

      • Dissolves at higher pH levels, potentially delaying absorption; hygroscopic nature may limit effectiveness.

    • Acrylate Polymers:

      • Eudragit L and S resist gastric fluid but dissolve at intestinal pH; available in various formulations.

    • Hydroxypropyl Methylcellulose Phthalate (HPMCP):

      • Soluble at lower pH, potentially enhancing bioavailability for specific drugs.

    Use of Plasticizers

    • Enhance the properties of polymer films, affecting flexibility, tensile strength, and adhesion.
    • Common plasticizers include castor oil, glycerin, and low-molecular-weight polyethylene glycols.
    • The choice and ratio of plasticizer optimize film properties.

    Colorants in Coating Solutions

    • Colorants enhance the visual appeal of tablets, either as soluble components or as suspended powders.
    • Proper distribution requires fine-powdered colorants to achieve uniformity in coating solutions.

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Description

    This quiz explores the various objectives and benefits of tablet coating in the pharmaceutical industry. It addresses how coating helps in masking taste, providing protection, controlling drug release, and shielding drugs from harsh gastric environments. Understanding these factors is crucial for making informed decisions in tablet manufacturing.

    More Quizzes Like This

    Mastering Tablet Coating in Industrial Pharmacy
    10 questions

    Mastering Tablet Coating in Industrial Pharmacy

    MarvellousTropicalRainforest avatar
    MarvellousTropicalRainforest
    Tablet Manufacturing and Quality Control in the Pharmaceutical Industry
    5 questions

    Tablet Manufacturing Quiz: What Tablet Should I Buy in Pharmaceutical...

    QuieterSheep avatar
    QuieterSheep
    (a) Push-pull Osmotic Pumps (PPOP)
    10 questions

    PPOP Quiz: Push-pull Osmotic Pumps Flashcards

    FlourishingSugilite5874 avatar
    FlourishingSugilite5874
    Sugar Coating Process in Pharmaceutical Tablets
    18 questions

    Sugar Coating Process in Pharmaceutical Tablets

    TopNotchFir avatar
    TopNotchFir
    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser