Podcast
Questions and Answers
What is the primary function of external plasticizers in coating solutions?
What is the primary function of external plasticizers in coating solutions?
- To increase drying time
- To impart flexibility and alter properties of films (correct)
- To act as a solvent
- To enhance color intensity
The choice of plasticizer does not affect the polymer's properties.
The choice of plasticizer does not affect the polymer's properties.
False (B)
Name one example of an external plasticizer used in coating formulations.
Name one example of an external plasticizer used in coating formulations.
Castor oil
The ability of a plasticizer to _____ the polymer is crucial for achieving desired film properties.
The ability of a plasticizer to _____ the polymer is crucial for achieving desired film properties.
Match the following types of colorants with their description:
Match the following types of colorants with their description:
What is one of the primary objectives of coating tablets?
What is one of the primary objectives of coating tablets?
Coating does not impact the cost of tablet production.
Coating does not impact the cost of tablet production.
Name one reason why tablets should be resistant to abrasion and chipping during the coating process.
Name one reason why tablets should be resistant to abrasion and chipping during the coating process.
The coating process can help protect drugs from the __________ environment.
The coating process can help protect drugs from the __________ environment.
Match the coating objective to its description:
Match the coating objective to its description:
Which of the following is NOT a primary component of tablet coating?
Which of the following is NOT a primary component of tablet coating?
The shape of the tablet is not significant in the coating process.
The shape of the tablet is not significant in the coating process.
What must tablets be protected from during the coating process?
What must tablets be protected from during the coating process?
Which property is NOT mentioned as a characteristic of the ideal polymer for film coating?
Which property is NOT mentioned as a characteristic of the ideal polymer for film coating?
Hydroxypropyl Methylcellulose (HPMC) interacts significantly with colorants.
Hydroxypropyl Methylcellulose (HPMC) interacts significantly with colorants.
What is one of the primary uses of Hydroxypropyl Methylcellulose in film coating?
What is one of the primary uses of Hydroxypropyl Methylcellulose in film coating?
Methyl Hydroxyethylcellulose is prepared by reacting alkali-treated cellulose first with _______ and then with ethylene oxide.
Methyl Hydroxyethylcellulose is prepared by reacting alkali-treated cellulose first with _______ and then with ethylene oxide.
Match the following film formers with their characteristics:
Match the following film formers with their characteristics:
What characteristic of a film former helps prevent bridging or filling on debossed tablet surfaces?
What characteristic of a film former helps prevent bridging or filling on debossed tablet surfaces?
Film formers can provide barriers against moisture and light when desired.
Film formers can provide barriers against moisture and light when desired.
What is a common application for film formers in the pharmaceutical industry?
What is a common application for film formers in the pharmaceutical industry?
Which polymer dissolves only above pH 6 and may delay drug absorption?
Which polymer dissolves only above pH 6 and may delay drug absorption?
Eudragit L is soluble in intestinal fluid at a pH of 7.
Eudragit L is soluble in intestinal fluid at a pH of 7.
What does HPMCP stand for?
What does HPMCP stand for?
Cellulose Acetate Phthalate is known to be _______ in comparison to other enteric polymers.
Cellulose Acetate Phthalate is known to be _______ in comparison to other enteric polymers.
Match the following enteric materials with their key characteristics:
Match the following enteric materials with their key characteristics:
What characteristic of HPMCP may result in higher bioavailability of specific drugs?
What characteristic of HPMCP may result in higher bioavailability of specific drugs?
Most commercially available enteric materials display at least two ideal coating properties.
Most commercially available enteric materials display at least two ideal coating properties.
Name two types of enteric acrylic resins mentioned.
Name two types of enteric acrylic resins mentioned.
What is the average molecular weight of povidone K-30?
What is the average molecular weight of povidone K-30?
Sodium carboxymethylcellulose is soluble in most organic solvents.
Sodium carboxymethylcellulose is soluble in most organic solvents.
What are the characteristics of dry povidone films?
What are the characteristics of dry povidone films?
Sodium carboxymethylcellulose is the sodium salt of __________.
Sodium carboxymethylcellulose is the sodium salt of __________.
Which of the following is NOT a primary use of povidone?
Which of the following is NOT a primary use of povidone?
Match the following materials with their properties:
Match the following materials with their properties:
Polyethylene glycols with high molecular weights are liquid at room temperature.
Polyethylene glycols with high molecular weights are liquid at room temperature.
What happens when sodium carboxymethylcellulose is added to water?
What happens when sodium carboxymethylcellulose is added to water?
Study Notes
Coating of Tablets: Purpose and Components
- Coating increases tablet manufacturing costs, yet serves several key purposes.
- Objectives include:
- Masking taste, odor, and color of drugs.
- Providing physical and chemical protection.
- Controlling drug release from tablets.
- Protecting drugs from the acidic gastric environment through enteric coating.
- Preventing chemical incompatibilities in multi-drug formulations.
- Enhancing pharmaceutical aesthetics with color and printing.
Primary Components of Tablet Coating
- Tablet coating involves three main components:
- Tablet properties.
- Coating compositions.
- Coating processes, including equipment and automation.
Tablet Properties
- Coated tablets must meet specific physical characteristics to withstand the coating process.
- Key physical traits include:
- Resistance to abrasion and chipping.
- Appropriate physical shape to maintain coating integrity.
- Compatibility with common additives in the coating solution.
- Non-toxic and no pharmacologic activity.
- Resistance to cracking and moisture/light barriers.
- No bridging or filling of debossed tablet surfaces.
- Adequate printing capability for high-speed equipment.
Film Formers: Nonenteric Materials
-
Hydroxypropyl Methylcellulose (HPMC):
- Ideal due to solubility, stability, flexibility, and non-interference in drug release.
- Tends to bridge surfaces; often mixed with other polymers to mitigate this issue.
-
Methyl Hydroxyethylcellulose:
- Clear, glossy films with excellent solubility in various solvents, widely used as a coating agent.
-
Sodium Carboxymethylcellulose:
- Forms brittle films that adhere well; less suited for organic solvent coatings but useful in aqueous systems.
-
Polyethylene Glycols (PEG):
- Low molecular weight variants serve as liquid plasticizers; high molecular weight variants provide solid coatings.
Enteric Coating Materials
-
Cellulose Acetate Phthalate (CAP):
- Dissolves at higher pH levels, potentially delaying absorption; hygroscopic nature may limit effectiveness.
-
Acrylate Polymers:
- Eudragit L and S resist gastric fluid but dissolve at intestinal pH; available in various formulations.
-
Hydroxypropyl Methylcellulose Phthalate (HPMCP):
- Soluble at lower pH, potentially enhancing bioavailability for specific drugs.
Use of Plasticizers
- Enhance the properties of polymer films, affecting flexibility, tensile strength, and adhesion.
- Common plasticizers include castor oil, glycerin, and low-molecular-weight polyethylene glycols.
- The choice and ratio of plasticizer optimize film properties.
Colorants in Coating Solutions
- Colorants enhance the visual appeal of tablets, either as soluble components or as suspended powders.
- Proper distribution requires fine-powdered colorants to achieve uniformity in coating solutions.
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Description
This quiz explores the various objectives and benefits of tablet coating in the pharmaceutical industry. It addresses how coating helps in masking taste, providing protection, controlling drug release, and shielding drugs from harsh gastric environments. Understanding these factors is crucial for making informed decisions in tablet manufacturing.
