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Questions and Answers
What is one of the major difficulties in the development of drugs for the CNS?
What is one of the major difficulties in the development of drugs for the CNS?
- Crossing the blood-brain barrier (BBB) (correct)
- Active efflux from the brain into the blood
- Passive diffusion
- Reaching peripheral immune cells
Which prodrug strategy involves increasing carrier-mediated or receptor mediated transport through the BBB?
Which prodrug strategy involves increasing carrier-mediated or receptor mediated transport through the BBB?
- Decreasing the active efflux of the drug from the brain into the blood
- Increasing passive diffusion by masking polar groups on the parent drug
- Increasing carrier-mediated or receptor mediated transport through the BBB (correct)
- Decreasing the process of prodrug biotransformation in peripheral tissues
Why is it essential for prodrug biotransformation to be slow in peripheral tissues but fast in the brain?
Why is it essential for prodrug biotransformation to be slow in peripheral tissues but fast in the brain?
- To prevent transport of nutrients into the brain
- To achieve therapeutically effective doses in the CNS (correct)
- To prevent central neurotransmitters from reaching the circulatory system
- To inhibit the passage of neurotoxic substances across the BBB
Which amino acid analog and precursor crosses the BBB via LAT1 and is then decarboxylated by AADC to dopamine?
Which amino acid analog and precursor crosses the BBB via LAT1 and is then decarboxylated by AADC to dopamine?
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How is transport of molecules across the BBB achieved?
How is transport of molecules across the BBB achieved?
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