5 Questions
What is one of the major difficulties in the development of drugs for the CNS?
Crossing the blood-brain barrier (BBB)
Which prodrug strategy involves increasing carrier-mediated or receptor mediated transport through the BBB?
Increasing carrier-mediated or receptor mediated transport through the BBB
Why is it essential for prodrug biotransformation to be slow in peripheral tissues but fast in the brain?
To achieve therapeutically effective doses in the CNS
Which amino acid analog and precursor crosses the BBB via LAT1 and is then decarboxylated by AADC to dopamine?
L-DOPA
How is transport of molecules across the BBB achieved?
Diffusion as a passive process
Explore the challenges and strategies for delivering therapeutically compounds to the central nervous system (CNS), including the role of the blood-brain barrier (BBB) and special carrier systems. Discover the concept of prodrug approaches in overcoming CNS delivery barriers.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
