Clopidogrel Flashcards

Questions and Answers

What is the brand name of clopidogrel?

Asprin

Clopidogrel

Aspirin

Plavix (correct)

What is the drug class of clopidogrel?

Platelet aggregation inhibitor

What are the dosage forms of clopidogrel?

Tablet, 75mg and 300mg

For acute myocardial infarction, the loading dose of clopidogrel is ________ mg.

300-600 Signup and view all the answers

What is the mechanism of action of clopidogrel?

Clopidogrel is an antiplatelet agent that prevents platelet aggregation by direct inhibition of ADP binding to receptor sites. Signup and view all the answers

Dose adjustment for renal function is required for clopidogrel.

False Signup and view all the answers

Dose adjustment for hepatic function is required for clopidogrel.

False Signup and view all the answers

What are the contraindications for clopidogrel?

Hypersensitivity to clopidogrel and active bleeding. Signup and view all the answers

Clopidogrel has a black box warning related to reduced CYP2C9 function.

True Signup and view all the answers

Name a drug that interacts with clopidogrel.

Amiodarone Signup and view all the answers

Match the following adverse reactions with their occurrence:

Common (>10%) = None Less common (1-10%) = Arthralgia, backache, epistaxis, gastritis, headache, hypertension, pruritus Signup and view all the answers

Study Notes

Clopidogrel Overview

Brand name is Plavix.

Classification

Falls under the platelet aggregation inhibitor drug class.

Dosage Forms

Available in tablet form: 75 mg and 300 mg doses.

Indications and Dosage

Acute Coronary Syndrome: Initial loading dose of 300-600 mg, followed by 75 mg daily along with aspirin.
Thrombosis Prevention: Administer 75 mg daily for conditions such as arteriosclerotic vascular disease, post-stroke, and peripheral arterial occlusive disease.

Mechanism of Action

Inhibits platelet aggregation by irreversibly blocking ADP binding to receptor sites, which prevents activation of the glycoprotein IIb/IIIa complex, affecting platelets for their lifespan.

Dose Adjustment

Renal Function: No dose adjustment required.
Hepatic Function: No dose adjustment required.

Contraindications

Avoid use in individuals with hypersensitivity to clopidogrel or those experiencing active bleeding.

Black Box Warning

Noted for patients with reduced CYP2C9 function.

Drug Interactions

Decreased Effect: Interactions with amiodarone, azole antifungals, calcium channel blockers, cimetidine, fluoxetine, fluvoxamine, and proton pump inhibitors can lower the platelet inhibitory effect.
Increased Bleeding Risk: Use with aspirin, cilostazol, thrombin inhibitors, fibrinolytics, fondaparinux, low-molecular-weight heparin, NSAIDs, SSRIs, ticlopidine, unfractionated heparin, and warfarin increases bleeding risk.
CYP Substrates: Clopidogrel affects the metabolism of CYP2B6 substrates and the activation of CYP2C19 inhibitors and inducers.

Adverse Reactions

Common (>10%): No significant reactions reported.
Less Common (1-10%): May cause arthralgia, backache, epistaxis, gastritis, headache, hypertension, and pruritus.

Description

This quiz features flashcards designed to help you learn about Clopidogrel, including its brand name, drug class, dosage forms, and indications for use. Perfect for pharmacy students or healthcare professionals looking to enhance their understanding of this important medication.