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Questions and Answers
What is the brand name of clopidogrel?
What is the brand name of clopidogrel?
What is the drug class of clopidogrel?
What is the drug class of clopidogrel?
Platelet aggregation inhibitor
What are the dosage forms of clopidogrel?
What are the dosage forms of clopidogrel?
Tablet, 75mg and 300mg
For acute myocardial infarction, the loading dose of clopidogrel is ________ mg.
For acute myocardial infarction, the loading dose of clopidogrel is ________ mg.
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What is the mechanism of action of clopidogrel?
What is the mechanism of action of clopidogrel?
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Dose adjustment for renal function is required for clopidogrel.
Dose adjustment for renal function is required for clopidogrel.
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Dose adjustment for hepatic function is required for clopidogrel.
Dose adjustment for hepatic function is required for clopidogrel.
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What are the contraindications for clopidogrel?
What are the contraindications for clopidogrel?
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Clopidogrel has a black box warning related to reduced CYP2C9 function.
Clopidogrel has a black box warning related to reduced CYP2C9 function.
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Name a drug that interacts with clopidogrel.
Name a drug that interacts with clopidogrel.
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Match the following adverse reactions with their occurrence:
Match the following adverse reactions with their occurrence:
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Study Notes
Clopidogrel Overview
- Brand name is Plavix.
Classification
- Falls under the platelet aggregation inhibitor drug class.
Dosage Forms
- Available in tablet form: 75 mg and 300 mg doses.
Indications and Dosage
- Acute Coronary Syndrome: Initial loading dose of 300-600 mg, followed by 75 mg daily along with aspirin.
- Thrombosis Prevention: Administer 75 mg daily for conditions such as arteriosclerotic vascular disease, post-stroke, and peripheral arterial occlusive disease.
Mechanism of Action
- Inhibits platelet aggregation by irreversibly blocking ADP binding to receptor sites, which prevents activation of the glycoprotein IIb/IIIa complex, affecting platelets for their lifespan.
Dose Adjustment
- Renal Function: No dose adjustment required.
- Hepatic Function: No dose adjustment required.
Contraindications
- Avoid use in individuals with hypersensitivity to clopidogrel or those experiencing active bleeding.
Black Box Warning
- Noted for patients with reduced CYP2C9 function.
Drug Interactions
- Decreased Effect: Interactions with amiodarone, azole antifungals, calcium channel blockers, cimetidine, fluoxetine, fluvoxamine, and proton pump inhibitors can lower the platelet inhibitory effect.
- Increased Bleeding Risk: Use with aspirin, cilostazol, thrombin inhibitors, fibrinolytics, fondaparinux, low-molecular-weight heparin, NSAIDs, SSRIs, ticlopidine, unfractionated heparin, and warfarin increases bleeding risk.
- CYP Substrates: Clopidogrel affects the metabolism of CYP2B6 substrates and the activation of CYP2C19 inhibitors and inducers.
Adverse Reactions
- Common (>10%): No significant reactions reported.
- Less Common (1-10%): May cause arthralgia, backache, epistaxis, gastritis, headache, hypertension, and pruritus.
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Description
This quiz features flashcards designed to help you learn about Clopidogrel, including its brand name, drug class, dosage forms, and indications for use. Perfect for pharmacy students or healthcare professionals looking to enhance their understanding of this important medication.
