Platelet Aggregation Inhibitors: Clopidogrel and Ticlopidine Quiz
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Questions and Answers

What is the mechanism of action of platelet aggregation inhibitors like Clopidogrel and Ticlopidine?

  • Increasing cAMP levels
  • Blocking binding sites on GPIIb/IIIa receptors (correct)
  • Binding to thrombin
  • Enhancing fibrinogen production
  • Which platelet aggregation inhibitor is a monoclonal antibody?

  • Dipyridamole
  • Abciximab (correct)
  • Clopidogrel
  • Eptifibatide
  • What is the mechanism of action of Dipyridamole?

  • Reducing cAMP levels
  • Inhibiting vitamin K synthesis
  • Blocking fibrinogen binding only
  • Increasing adenosine levels and blocking fibrinogen binding (correct)
  • Which platelet aggregation inhibitor is indicated for reducing symptoms of intermittent claudication?

    <p>Cilostazol</p> Signup and view all the answers

    What do anticoagulants like Heparin and LMWH primarily target in the coagulation cascade?

    <p>Thrombin (Factor II)</p> Signup and view all the answers

    Why are LMWHs considered favorable for pregnant women?

    <p>They have a predictable anticoagulant effect</p> Signup and view all the answers

    Which anticoagulant is initially used as rat poison?

    <p>Warfarin</p> Signup and view all the answers

    What is the mechanism of action of thrombolytic agents like Alteplase and Streptokinase?

    <p>Directly inhibiting thrombin</p> Signup and view all the answers

    What is the primary adverse effect of thrombolytic agents like Streptokinase?

    <p>Hemorrhage</p> Signup and view all the answers

    Which factor is responsible for the formation of a hemostatic plug by stabilizing inactive GP IIb/ IIIa receptors?

    <p>Prostacyclin</p> Signup and view all the answers

    What effect does acetylsalicylic acid (ASA) have on COX-1?

    <p>It prevents arachidonate from binding to the active site.</p> Signup and view all the answers

    What is the main role of thrombolytic drugs in the context of clot formation?

    <p>Limiting the growth of the clot and dissolving fibrin network</p> Signup and view all the answers

    Which drug inhibits the binding of Adenosine diphosphate (ADP), thereby preventing the activation of GIIb/IIIa receptors?

    <p>Clopidogrel (Plavix)</p> Signup and view all the answers

    What is the primary function of Factor XIII in the coagulation cascade?

    <p>Promoting fibrin formation</p> Signup and view all the answers

    Which agent acts by irreversibly acetylating a serine on COX-1, leading to inhibition of thromboxane A2 synthesis?

    <p>Acetylsalicylic Acid (ASA)</p> Signup and view all the answers

    What effect does prostacyclin have on platelet function?

    <p>Decreases intracellular Ca2+ levels</p> Signup and view all the answers

    Which drug is considered a hemorheologic agent?

    <p>Dipyridamole</p> Signup and view all the answers

    What is the primary effect of Factor XIII in the coagulation cascade?

    <p>Promotion of fibrin formation</p> Signup and view all the answers

    Which condition can be prevented or treated using platelet aggregation inhibitors?

    <p>Ischemic Strokes</p> Signup and view all the answers

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