19 Questions
What is the mechanism of action of platelet aggregation inhibitors like Clopidogrel and Ticlopidine?
Blocking binding sites on GPIIb/IIIa receptors
Which platelet aggregation inhibitor is a monoclonal antibody?
Abciximab
What is the mechanism of action of Dipyridamole?
Increasing adenosine levels and blocking fibrinogen binding
Which platelet aggregation inhibitor is indicated for reducing symptoms of intermittent claudication?
Cilostazol
What do anticoagulants like Heparin and LMWH primarily target in the coagulation cascade?
Thrombin (Factor II)
Why are LMWHs considered favorable for pregnant women?
They have a predictable anticoagulant effect
Which anticoagulant is initially used as rat poison?
Warfarin
What is the mechanism of action of thrombolytic agents like Alteplase and Streptokinase?
Directly inhibiting thrombin
What is the primary adverse effect of thrombolytic agents like Streptokinase?
Hemorrhage
Which factor is responsible for the formation of a hemostatic plug by stabilizing inactive GP IIb/ IIIa receptors?
Prostacyclin
What effect does acetylsalicylic acid (ASA) have on COX-1?
It prevents arachidonate from binding to the active site.
What is the main role of thrombolytic drugs in the context of clot formation?
Limiting the growth of the clot and dissolving fibrin network
Which drug inhibits the binding of Adenosine diphosphate (ADP), thereby preventing the activation of GIIb/IIIa receptors?
Clopidogrel (Plavix)
What is the primary function of Factor XIII in the coagulation cascade?
Promoting fibrin formation
Which agent acts by irreversibly acetylating a serine on COX-1, leading to inhibition of thromboxane A2 synthesis?
Acetylsalicylic Acid (ASA)
What effect does prostacyclin have on platelet function?
Decreases intracellular Ca2+ levels
Which drug is considered a hemorheologic agent?
Dipyridamole
What is the primary effect of Factor XIII in the coagulation cascade?
Promotion of fibrin formation
Which condition can be prevented or treated using platelet aggregation inhibitors?
Ischemic Strokes
Test your knowledge on platelet aggregation inhibitors, specifically Clopidogrel (Plavix®) and Ticlopidine (Ticlid®). Learn about the adverse effects, indications, and differences between the two medications.
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