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Clopidogrel Pharmacokinetics and Pharmacogenomics Quiz

10 Questions

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Clopidogrel Pharmacokinetics and Pharmacogenomics Quiz

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Questions and Answers

What is the primary route of excretion for clopidogrel?

Feces only

Exhaled air

Equally in urine and feces (correct)

Urine only

What effect would co-prescribing a CYP2C19 inhibitor with clopidogrel have?

Decreased risk of bleeding

No effect on adverse effects

Reduced risk of thrombotic thrombocytopenic purpura

Increased risk of bleeding (correct)

What is the mechanism of action of abciximab?

Competitive antagonism of glycoprotein IIb/IIIa receptor complex (correct)

Prevention of platelet aggregation via binding to thromboxane A2 receptor

Inhibition of thrombin activity

Inhibition of P450 CYP2C19 enzyme

What is the mechanism of action of aspirin?

Inhibition of thromboxane A2 production Signup and view all the answers

For which condition is aspirin used in patients undergoing percutaneous coronary intervention (PCI)?

Preventing acute cardiac ischemic complications Signup and view all the answers

In what type of patients is aspirin used to manage unstable angina not responding to conventional therapy?

Patients scheduled for PCI Signup and view all the answers

What is the mechanism of action of direct thrombin inhibitors (DTIs)?

Binding to the active site of both free and fibrin-bound thrombin Signup and view all the answers

In which patient population can bivalirudin be used as an alternative to heparin?

Patients with heparin-induced thrombocytopenia Signup and view all the answers

What is a common adverse effect associated with dabigatran use?

Gastrointestinal adverse effects Signup and view all the answers

Why are elderly patients more sensitive to the anticoagulation effects of certain medications?

Due to decreased metabolism and elimination of the medication in the elderly population Signup and view all the answers