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Questions and Answers
What is the class for clopidogrel/Plavix?
What is the class for clopidogrel/Plavix?
Thienopyridine antiplatelet
What is the MOA for clopidogrel/Plavix?
What is the MOA for clopidogrel/Plavix?
Inhibits platelet aggregation by blocking activation of the glycoprotein IIb/IIIa complex
What are the indications for clopidogrel/Plavix?
What are the indications for clopidogrel/Plavix?
STEMI, moderate to high-risk non-STEMI, substitute for Aspirin for patients unable to take Aspirin
List the contraindications for clopidogrel/Plavix.
List the contraindications for clopidogrel/Plavix.
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List adverse reactions/side effects for clopidogrel/Plavix.
List adverse reactions/side effects for clopidogrel/Plavix.
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List the drug interactions for clopidogrel/Plavix.
List the drug interactions for clopidogrel/Plavix.
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How is clopidogrel/Plavix supplied?
How is clopidogrel/Plavix supplied?
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List the adult dosage for clopidogrel/Plavix.
List the adult dosage for clopidogrel/Plavix.
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List the pediatric dosage for clopidogrel/Plavix.
List the pediatric dosage for clopidogrel/Plavix.
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List the duration of action for clopidogrel/Plavix.
List the duration of action for clopidogrel/Plavix.
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Study Notes
Clopidogrel (Plavix) Overview
- Classifies as a thienopyridine antiplatelet medication.
- Primarily used to prevent blood clots in various cardiovascular conditions.
Mechanism of Action
- Functions by inhibiting platelet aggregation.
- Blocks the activation of the glycoprotein IIb/IIIa complex, crucial for platelet clumping.
Indications
- Effective for ST-elevation myocardial infarction (STEMI) cases.
- Recommended for moderate to high-risk non-ST-elevation myocardial infarction (non-STEMI).
- Serves as a substitute for aspirin in patients who cannot tolerate it.
Contraindications
- Not safe in patients with active gastrointestinal bleeding or recent intracranial hemorrhage.
- Individuals with known hypersensitivity to clopidogrel should avoid this medication.
Adverse Reactions and Side Effects
- Potentially severe adverse effects include:
- Severe neutropenia (low neutrophil count).
- Thrombotic thrombocytopenic purpura (TTP), a rare but serious condition.
- Risks of gastrointestinal and cerebral hemorrhage.
- Angioedema, marked by swelling beneath the skin.
- Flu-like symptoms may also occur.
Drug Interactions
- Use caution in combination with proton pump inhibitors, which may reduce clopidogrel's effectiveness.
- Co-administration with other anticoagulants like warfarin and aspirin necessitates careful monitoring.
Formulation and Dosage
- Supplied in oral tablet form at strengths of 75mg and 300mg.
- Loading dose recommended at 300-600mg by mouth for adults.
- Not advised for pediatric use due to limited safety and efficacy data.
Duration of Action
- Exhibits rapid onset, with peak effect occurring within 1 hour.
- Effects can last for 7-10 days, reflecting its role in inhibiting platelet function over an extended period.
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Test your knowledge about Clopidogrel (Plavix) with these flashcards. Each card covers essential information, including its classification, mechanism of action, and clinical indications. Perfect for students in pharmacology or healthcare fields looking to reinforce their understanding.
