Questions and Answers
What are the brand and generic names of clopidogrel bisulfate?
What is the drug/chemical class of clopidogrel bisulfate?
P2Y12 platelet inhibitor
What is the primary indication for clopidogrel bisulfate?
Acute coronary syndrome
The initial starting dose for unstable angina is a 300 mg loading dose followed by __________ once daily.
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What is the most commonly reported adverse effect of clopidogrel bisulfate?
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Which of the following are contraindications for clopidogrel bisulfate? (Select all that apply)
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What is the mechanism of action for clopidogrel bisulfate?
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What types of drugs can interact with clopidogrel bisulfate?
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What should a patient do if they experience severe side effects while taking clopidogrel bisulfate?
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Study Notes
Clopidogrel Bisulfate Overview
- Brand name: Plavix; Generic name: clopidogrel bisulfate
- Belongs to the P2Y12 platelet inhibitor class, functioning as a hematological agent.
Primary Use
- Indicated for acute coronary syndrome related to atherosclerosis.
Dosing Guidelines
- For unstable angina/non-ST-elevation myocardial infarction (UA/NSTEMI): Initial loading dose of 300 mg, followed by 75 mg daily
- For ST-elevation myocardial infarction (STEMI): Typically, 75 mg daily without a loading dose.
Adverse Effects
- Major risk includes bleeding, with reports of life-threatening and fatal cases being common.
Contraindications
- Not suitable for patients with active pathological bleeding, such as peptic ulcers or intracranial hemorrhages.
- Hypersensitivity reactions to clopidogrel or its components also contraindicate its use.
Mechanism of Action
- Inhibits platelet activation and aggregation by irreversibly binding to P2Y12 ADP receptors on platelets, preventing platelet aggregation.
Drug Interactions
- Co-administration with NSAIDs, warfarin, SSRIs, or SNRIs raises the risk of bleeding occurrences.
Patient Counseling Tips
- Advise patients to contact their physician for severe or persistent side effects and any signs of infection.
- Clopidogrel can be taken with or without food.
- Patients should report unusual bleeding as therapy increases bleeding time.
- Instruct to take as directed and avoid over-the-counter omeprazole products.
- If a dose is missed, take it as soon as possible unless close to the next dose time; do not double the doses.
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Description
Test your knowledge on Clopidogrel Bisulfate with these flashcards. Each card covers key aspects including brand and generic names, drug class, primary indications, and dosing information. Perfect for healthcare students and professionals!
