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Questions and Answers
What is the mechanism of action of fondaparinux?
What is the mechanism of action of fondaparinux?
- It accelerates the normal rate of inactivation of active clotting factors by prothrombin
- It inactivates factor Xa only (correct)
- It inactivates both thrombin and Xa equally
- It serves as a catalytic surface for antithrombin and thrombin
How does fondaparinux differ from heparin in terms of selectivity?
How does fondaparinux differ from heparin in terms of selectivity?
- Heparin inactivates thrombin and Xa equally (correct)
- Heparin inactivates factor Xa poorly
- Fondaparinux inactivates thrombin and Xa equally
- Heparin inactivates factor Xa only
How is the onset of anticoagulant effect for fondaparinux described?
How is the onset of anticoagulant effect for fondaparinux described?
- Is immediately effective upon oral administration
- Has a delayed onset after SC administration
- Occurs rapidly within minutes of IV administration (correct)
- Occurs slowly over hours after IV administration
What is the clearance route for LMWH and fondaparinux?
What is the clearance route for LMWH and fondaparinux?
When are LMWH and fondaparinux usually indicated over heparin?
When are LMWH and fondaparinux usually indicated over heparin?
What is the primary target for fondaparinux inactivation?
What is the primary target for fondaparinux inactivation?
Which type of cells does heparin bind to?
Which type of cells does heparin bind to?
LMWH and fondaparinux do not require monitoring because:
LMWH and fondaparinux do not require monitoring because:
Heparin is usually given by which route of administration?
Heparin is usually given by which route of administration?
How does fondaparinux differ from LMWH in terms of inactivation?
How does fondaparinux differ from LMWH in terms of inactivation?
What is the primary mechanism through which fondaparinux exerts its anticoagulant effect?
What is the primary mechanism through which fondaparinux exerts its anticoagulant effect?
How is heparin mainly cleared from the body?
How is heparin mainly cleared from the body?
What distinguishes the pharmacokinetics of LMWH/fondaparinux from heparin?
What distinguishes the pharmacokinetics of LMWH/fondaparinux from heparin?
What is the primary advantage of using fondaparinux during outpatient transition to warfarin?
What is the primary advantage of using fondaparinux during outpatient transition to warfarin?
Why is LMWH preferred over heparin for certain indications?
Why is LMWH preferred over heparin for certain indications?
Which of the following statements about the mechanism of fondaparinux is correct?
Which of the following statements about the mechanism of fondaparinux is correct?
'Circulating thrombin only, no clot bound' describes which aspect of fondaparinux's mechanism?
'Circulating thrombin only, no clot bound' describes which aspect of fondaparinux's mechanism?
'Parenteral' anticoagulant refers to medications that are typically administered through which route?
'Parenteral' anticoagulant refers to medications that are typically administered through which route?
What is one advantage of using LMWH/fondaparinux over heparin in terms of monitoring requirements?
What is one advantage of using LMWH/fondaparinux over heparin in terms of monitoring requirements?
What is the mechanism of action of abciximab (ReoPro®)?
What is the mechanism of action of abciximab (ReoPro®)?
What is the pharmacokinetics of vorapaxar (Zontivity®)?
What is the pharmacokinetics of vorapaxar (Zontivity®)?
What is the primary therapeutic use of abciximab (ReoPro®)?
What is the primary therapeutic use of abciximab (ReoPro®)?
Which adverse effect is specifically associated with vorapaxar (Zontivity®)?
Which adverse effect is specifically associated with vorapaxar (Zontivity®)?
How does abciximab (ReoPro®) achieve a long duration of action despite a short half-life?
How does abciximab (ReoPro®) achieve a long duration of action despite a short half-life?
In what way does vorapaxar (Zontivity®) differ from abciximab (ReoPro®) in terms of therapeutic use?
In what way does vorapaxar (Zontivity®) differ from abciximab (ReoPro®) in terms of therapeutic use?
Which of the following accurately describes the mechanism of action of fondaparinux?
Which of the following accurately describes the mechanism of action of fondaparinux?
What distinguishes the pharmacokinetics of heparin from LMWH/fondaparinux?
What distinguishes the pharmacokinetics of heparin from LMWH/fondaparinux?
What is the main selective action of fondaparinux compared to heparin and LMWH?
What is the main selective action of fondaparinux compared to heparin and LMWH?
During which medical procedures is fondaparinux commonly used to prevent thrombosis?
During which medical procedures is fondaparinux commonly used to prevent thrombosis?
What is the route of administration for heparin that distinguishes it from LMWH/fondaparinux?
What is the route of administration for heparin that distinguishes it from LMWH/fondaparinux?
Which of the following statements accurately describes the onset of anticoagulant effect in fondaparinux?
Which of the following statements accurately describes the onset of anticoagulant effect in fondaparinux?
What is the mechanism of action of clopidogrel (Plavix®)?
What is the mechanism of action of clopidogrel (Plavix®)?
Which statement regarding clopidogrel's pharmacokinetics is accurate?
Which statement regarding clopidogrel's pharmacokinetics is accurate?
In which patient population is clopidogrel indicated for use?
In which patient population is clopidogrel indicated for use?
Which adverse effect is associated with clopidogrel use?
Which adverse effect is associated with clopidogrel use?
How does clopidogrel compare to aspirin in terms of efficacy and cost?
How does clopidogrel compare to aspirin in terms of efficacy and cost?
What is the primary role of ADP receptor antagonists like clopidogrel in combination with aspirin?
What is the primary role of ADP receptor antagonists like clopidogrel in combination with aspirin?
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