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Questions and Answers
What is the primary mechanism of action of NSAIDs?
What is the primary mechanism of action of NSAIDs?
Which type of anti-inflammatory drug is used to treat rheumatoid arthritis?
Which type of anti-inflammatory drug is used to treat rheumatoid arthritis?
What is a common side effect of NSAIDs?
What is a common side effect of NSAIDs?
What is the mechanism of action of corticosteroids?
What is the mechanism of action of corticosteroids?
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What is a contraindication for corticosteroids?
What is a contraindication for corticosteroids?
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What is the primary use of DMARDs?
What is the primary use of DMARDs?
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What is a potential side effect of DMARDs?
What is a potential side effect of DMARDs?
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What is a common use of anti-inflammatory drugs?
What is a common use of anti-inflammatory drugs?
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Study Notes
Classification of Anti-Inflammatory Drugs
-
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs):
- Inhibit cyclooxygenase (COX) enzymes, which produce prostaglandins that cause inflammation
- Examples: aspirin, ibuprofen, naproxen, celecoxib
-
Corticosteroids:
- Synthetic versions of hormones produced by the adrenal gland
- Reduce inflammation by suppressing the immune system
- Examples: prednisone, hydrocortisone
-
Disease-Modifying Anti-Rheumatic Drugs (DMARDs):
- Modify the course of rheumatic diseases, such as rheumatoid arthritis
- Examples: methotrexate, sulfasalazine, leflunomide
Mechanisms of Action
- COX inhibition: NSAIDs inhibit COX-1 and COX-2 enzymes, reducing prostaglandin production
- Immune system suppression: Corticosteroids suppress the immune system, reducing inflammation
- Anti-inflammatory cytokines: DMARDs may inhibit pro-inflammatory cytokines and stimulate anti-inflammatory cytokines
Uses
- Pain relief: NSAIDs and corticosteroids are used to relieve pain and reduce inflammation
- Rheumatic diseases: DMARDs are used to treat rheumatoid arthritis, psoriatic arthritis, and other rheumatic diseases
- Other conditions: Anti-inflammatory drugs may be used to treat conditions such as asthma, allergies, and skin conditions
Side Effects
- Gastrointestinal: NSAIDs can cause stomach ulcers, bleeding, and digestive problems
- Cardiovascular: NSAIDs may increase the risk of heart attacks and strokes
- Immunosuppression: Corticosteroids can suppress the immune system, increasing the risk of infections
- Hepatotoxicity: Some DMARDs can cause liver damage
Contraindications
- NSAIDs: Contraindicated in patients with stomach ulcers, bleeding, or kidney disease
- Corticosteroids: Contraindicated in patients with infections, diabetes, or osteoporosis
- DMARDs: Contraindicated in patients with liver disease, kidney disease, or bone marrow suppression
Classification of Anti-Inflammatory Drugs
- Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) inhibit cyclooxygenase (COX) enzymes, producing prostaglandins that cause inflammation
- Examples of NSAIDs include aspirin, ibuprofen, naproxen, and celecoxib
Corticosteroids
- Are synthetic versions of hormones produced by the adrenal gland
- Reduce inflammation by suppressing the immune system
- Examples of corticosteroids include prednisone and hydrocortisone
Disease-Modifying Anti-Rheumatic Drugs (DMARDs)
- Modify the course of rheumatic diseases, such as rheumatoid arthritis
- Examples of DMARDs include methotrexate, sulfasalazine, and leflunomide
Mechanisms of Action
- NSAIDs inhibit COX-1 and COX-2 enzymes, reducing prostaglandin production
- Corticosteroids suppress the immune system, reducing inflammation
- DMARDs may inhibit pro-inflammatory cytokines and stimulate anti-inflammatory cytokines
Uses
- NSAIDs and corticosteroids are used to relieve pain and reduce inflammation
- DMARDs are used to treat rheumatoid arthritis, psoriatic arthritis, and other rheumatic diseases
- Anti-inflammatory drugs may be used to treat conditions such as asthma, allergies, and skin conditions
Side Effects
- NSAIDs can cause stomach ulcers, bleeding, and digestive problems
- NSAIDs may increase the risk of heart attacks and strokes
- Corticosteroids can suppress the immune system, increasing the risk of infections
- Some DMARDs can cause liver damage
Contraindications
- NSAIDs are contraindicated in patients with stomach ulcers, bleeding, or kidney disease
- Corticosteroids are contraindicated in patients with infections, diabetes, or osteoporosis
- DMARDs are contraindicated in patients with liver disease, kidney disease, or bone marrow suppression
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Description
This quiz covers the classification of anti-inflammatory drugs, including Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Corticosteroids, and Disease-Modifying Anti-Rheumatic Drugs (DMARDs).
