Inflammatory Response Quiz (BMS Learning Outcomes)
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Questions and Answers

What is the primary reason for rubor (redness) during acute inflammation?

  • Release of proteolytic enzymes
  • Increased blood flow due to vasodilation (correct)
  • Accumulation of white blood cells
  • Increased oxygen demand in tissues
  • Which of the following is a component of the classical signs of acute inflammation?

  • Activation of T-cells
  • Increased temperature (correct)
  • Formation of scar tissue
  • Secretion of antibodies
  • Which type of exudate is characterized by fluid collection due to burns?

  • Suppurative exudate
  • Serous exudate (correct)
  • Ulcerative exudate
  • Fibrinous exudate
  • What is not a factor contributing to increased vascular permeability?

    <p>Endothelial repair (D)</p> Signup and view all the answers

    What is the primary function of opsonization in inflammation?

    <p>To mark pathogens for phagocytosis (C)</p> Signup and view all the answers

    Which process significantly contributes to the slowing of microcirculation during inflammation?

    <p>Transudation of fluid (B)</p> Signup and view all the answers

    Which of the following is a type of phagocytic cell involved in the inflammatory response?

    <p>Macrophages (C)</p> Signup and view all the answers

    Which inflammatory response is characterized by the formation of purulent material?

    <p>Suppurative inflammation (B)</p> Signup and view all the answers

    What is one of the early vascular events in acute inflammation?

    <p>Persistent vasodilation (A)</p> Signup and view all the answers

    What type of injury can lead to increased vascular permeability during inflammation?

    <p>Endothelial injury (D)</p> Signup and view all the answers

    What role do cytokines play in inflammation?

    <p>They mediate and regulate immune and inflammatory reactions. (D)</p> Signup and view all the answers

    Which of the following statements about histamines is correct?

    <p>Histamines cause vasodilation and increase blood flow. (A)</p> Signup and view all the answers

    Which mediators are typically associated with the effects of leukotrienes?

    <p>Histamines and prostaglandins. (C)</p> Signup and view all the answers

    What is a characteristic of chronic inflammation?

    <p>It can lead to more tissue damage over time. (C)</p> Signup and view all the answers

    What are chemokines primarily responsible for?

    <p>Acting as chemotactic agents for specific leukocytes. (D)</p> Signup and view all the answers

    What is a common cause of chronic inflammation?

    <p>Local ischemia or foreign bodies. (A)</p> Signup and view all the answers

    Which of the following statements about prostaglandins is true?

    <p>They can cause fever and pain during inflammation. (B)</p> Signup and view all the answers

    How do endogenous chemical mediators differ from exogenous mediators?

    <p>Endogenous mediators come from the body, while exogenous are from outside. (D)</p> Signup and view all the answers

    What is a common outcome of chronic inflammation regarding tissue appearance?

    <p>A more fibrotic appearance of tissues. (D)</p> Signup and view all the answers

    What effect do leukotrienes have during inflammation?

    <p>They act as chemotactic agents for neutrophils. (B)</p> Signup and view all the answers

    Flashcards

    Rubor (Redness)

    Redness caused by increased blood flow to the inflamed area.

    Calor (Heat)

    Heat or warmth in the inflamed area due to increased blood flow.

    Tumor (Swelling)

    Swelling or edema caused by fluid accumulation in the inflamed tissue.

    Dolor (Pain)

    Pain caused by the release of chemical mediators that stimulate nerve endings.

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    Loss of Function

    A loss of function caused by inflammation, preventing the affected area from working properly.

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    Serous Inflammation

    Inflammation characterized by the release of watery fluid (serum) that accumulates in the affected area. Often caused by burns, blisters, or other mild injuries.

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    Fibrinous Inflammation

    Inflammation marked by the deposition of fibrin (a sticky protein) in the affected area. This can be seen in conditions like cancer, where it can lead to tissue scarring.

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    Suppurative Inflammation

    Inflammation characterized by the formation of pus (dead white blood cells) in the affected area. Often caused by bacterial infections.

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    Ulcerative Inflammation

    Inflammation causing a break in the surface of epithelial tissue (skin, lining of organs). Can become chronic and lead to ulcers.

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    Phagocytosis

    Process in which phagocytic cells, like neutrophils and macrophages, engulf and destroy foreign invaders, cellular debris, or other harmful substances.

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    Chemical Mediators

    Chemicals released by the body during inflammation, like histamine and leukotrienes, that have various effects on tissues.

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    Vasodilator

    A type of chemical mediator involved in inflammation that causes blood vessels to widen.

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    Vasoconstrictor

    A type of chemical mediator in inflammation that causes blood vessels to narrow.

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    Prostaglandins

    A potent chemical mediator involved in inflammation that causes blood vessels to dilate, fever, and pain.

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    Chemoattractant

    A type of chemical mediator in inflammation that helps attract white blood cells to the site of injury or infection.

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    Chemokines

    A group of chemical mediators that act as chemoattractants for specific types of white blood cells.

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    Chronic Inflammation

    Inflammation that lasts for a long time, often months or years.

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    Acute Inflammation

    Inflammation that occurs quickly and lasts for a short time.

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    Granuloma

    A small, localized area of chronic inflammation that contains a collection of immune cells.

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    Contributing Factors to Chronic Inflammation

    Factors that increase the likelihood of developing chronic inflammation.

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    Study Notes

    Classical Signs of Acute Inflammation

    • Rubor (redness): Caused by blood vessel dilation (vasodilation).
    • Calor (heat): Resulting from increased blood flow.
    • Tumor (swelling): Due to fluid leakage into tissues.
    • Dolor (pain): Triggered by chemical mediators and pressure.
    • Loss of function: Impaired tissue/organ performance.

    Types of Acute Inflammation

    • Serous inflammation: Fluid-filled blisters (e.g., burns).
    • Fibrinous inflammation: Fibrin leakage, often seen in cancer.
    • Suppurative (purulent) inflammation: Pus formation (dead tissue).
    • Ulcerative inflammation: Break in epithelial surface; can become chronic.

    Formation of Exudate

    • Fluid exudate: Accumulation of fluid due to increased hydrostatic pressure.
    • Cellular exudate: Leukocytes (especially neutrophils) recruited to the site.

    Causes of Acute Inflammation

    • Vascular events:
      • Persistent vasodilation
      • Elevated hydrostatic pressure
      • Increased vascular permeability (endothelial cell contraction, injury, increased transcytosis, new blood vessel leakage)
      • Microcirculation slowing/stasis.

    Phagocytosis and Bacterial Killing

    • Phagocytic cells: Neutrophils (early response), monocytes/macrophages.
    • Opsonisation: "Markers" on bacteria enhance phagocytosis.
    • Phagocytosis process: Engulfment and destruction of pathogens/debris.
    • Enzyme release: Neutrophils/macrophages release proteolytic enzymes (e.g., protease, elastase, collagenase, lipase) to degrade pathogens.

    Chemical Mediators of Acute Inflammation

    • Exogenous mediators: From pathogens (e.g., endotoxins).
    • Endogenous mediators: Body-derived (e.g., cytokines, Histamine, Leukotrienes, Prostaglandins, Chemokines).
      • Cytokines: Produced by various cells (macrophages, lymphocytes, epithelial cells), regulating immune/inflammatory reactions (pro-inflammatory & anti-inflammatory effects).
      • Histamine: Triggers vasodilation.
      • Leukotrienes: Increase vascular permeability; cause vasoconstriction.
      • Prostaglandins: Lipid compounds; involved in vascular and systemic reactions (vasodilation, fever, pain), derived from mast cells, macrophages, endothelial cells.
      • Chemokines: Small proteins attracting specific types of leukocytes.

    Chronic Inflammation

    • Process: Longer duration, typically with more tissue damage than acute.
    • Cells: Predominantly lymphocytes.
    • Appearance: More fibrosis.
    • Host defense: Unable to effectively clear the insult.
    • Granuloma formation: Often present.

    Contributing Factors to Chronic Inflammation

    • Local: Ischemia, foreign body, infection.
    • Systemic: Age, gender, hormones, alcoholism, stress, obesity, nutrition, immune compromise (disease/medication).

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    Description

    This quiz covers the classical signs of acute inflammation, including redness, heat, swelling, pain, and loss of function. It also explores different types of acute inflammation such as serous, fibrinous, and suppurative inflammation, as well as the formation and causes of exudate. Test your understanding of these essential concepts in inflammation pathology.

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