Podcast
Questions and Answers
What characteristic of sinusoids and sinus capillaries allows for blood cell traffic?
What characteristic of sinusoids and sinus capillaries allows for blood cell traffic?
- Lack of smooth muscle
- High permeability (correct)
- Low pressure
- Narrow diameter
Where do most cells receive their oxygen and nutrients from?
Where do most cells receive their oxygen and nutrients from?
- Through the vascular channels
- Directly from the capillaries
- From the plasma
- From the interstitial fluid (correct)
What is the primary cause of intermittent blood flow within the capillary bed?
What is the primary cause of intermittent blood flow within the capillary bed?
- Plasma content fluctuation
- Vasomotion (correct)
- Arteriole innervation
- Constant sphincter contraction
What is the typical percentage of solids in blood plasma?
What is the typical percentage of solids in blood plasma?
What happens to blood flow if there is a decrease in local tissue oxygen levels?
What happens to blood flow if there is a decrease in local tissue oxygen levels?
Which of the following best describes the tunica media of elastic arteries?
Which of the following best describes the tunica media of elastic arteries?
In an open circulatory system, how does blood return to the heart after circulating through the body?
In an open circulatory system, how does blood return to the heart after circulating through the body?
What is the primary function of the vasa vasorum?
What is the primary function of the vasa vasorum?
Which of the following accurately describes the primary function of the blood vascular system?
Which of the following accurately describes the primary function of the blood vascular system?
How are the walls of capillaries generally structured?
How are the walls of capillaries generally structured?
What best describes the transition from arteries to veins in the circulatory pathway?
What best describes the transition from arteries to veins in the circulatory pathway?
What is the role of precapillary sphincters in a capillary bed?
What is the role of precapillary sphincters in a capillary bed?
Which sequence correctly represents the flow of blood from the aorta back to the vena cava?
Which sequence correctly represents the flow of blood from the aorta back to the vena cava?
What is the relative amount of smooth muscle and elastic tissue in muscular arteries?
What is the relative amount of smooth muscle and elastic tissue in muscular arteries?
What makes blood vessels distinct from just being metallic pipes?
What makes blood vessels distinct from just being metallic pipes?
Which of the following is closest to the typical diameter of a capillary?
Which of the following is closest to the typical diameter of a capillary?
Among the given options, which best describes the role of metarterioles within the vascular system?
Among the given options, which best describes the role of metarterioles within the vascular system?
What type of nerve supply modulates the blood flow in an artery?
What type of nerve supply modulates the blood flow in an artery?
In the circulatory system, where do metarterioles directly lead?
In the circulatory system, where do metarterioles directly lead?
Aside from the blood vascular system, how many other major fluid systems are identified in the human body?
Aside from the blood vascular system, how many other major fluid systems are identified in the human body?
What are the structures responsible for carrying out all transport in the blood system?
What are the structures responsible for carrying out all transport in the blood system?
What is the total percentage of solids in blood plasma as described in the text?
What is the total percentage of solids in blood plasma as described in the text?
Which of the following does NOT contribute to the total protein content of blood plasma?
Which of the following does NOT contribute to the total protein content of blood plasma?
Why does fluid exit arterial capillaries, according to the text?
Why does fluid exit arterial capillaries, according to the text?
What is the main reason that most of the fluid that leaves the capillaries is reabsorbed?
What is the main reason that most of the fluid that leaves the capillaries is reabsorbed?
Which pressure has the primary effect of drawing fluid back into the capillary?
Which pressure has the primary effect of drawing fluid back into the capillary?
What does the term 'fluid exchange' refer to?
What does the term 'fluid exchange' refer to?
What is the approximate value of plasma colloid osmotic pressure, as mentioned in the text?
What is the approximate value of plasma colloid osmotic pressure, as mentioned in the text?
Which pressure is described as a negative value?
Which pressure is described as a negative value?
What is the primary function of lymphatic capillaries in relation to interstitial fluid?
What is the primary function of lymphatic capillaries in relation to interstitial fluid?
Why is monitoring the fluid returning to the blood through the lymphatic system considered important?
Why is monitoring the fluid returning to the blood through the lymphatic system considered important?
What is the specific anatomical feature of lymphatic capillaries that allows them to collect interstitial fluid?
What is the specific anatomical feature of lymphatic capillaries that allows them to collect interstitial fluid?
What is the immediate destination of the interstitial fluid that enters the lymphatic capillaries?
What is the immediate destination of the interstitial fluid that enters the lymphatic capillaries?
What would happen if the lymphatic system failed to return fluid to the circulation?
What would happen if the lymphatic system failed to return fluid to the circulation?
What is the primary determinant of fluid movement across capillary walls?
What is the primary determinant of fluid movement across capillary walls?
What is the net fluid pressure in the arterial end of the capillary?
What is the net fluid pressure in the arterial end of the capillary?
Why is interstitial fluid pressure typically negative?
Why is interstitial fluid pressure typically negative?
Which of the following net fluid exchange events is NOT directly reabsorbed by venous capillaries?
Which of the following net fluid exchange events is NOT directly reabsorbed by venous capillaries?
How does the colloid osmotic pressure influence fluid dynamics at the capillary level?
How does the colloid osmotic pressure influence fluid dynamics at the capillary level?
What is the estimated total body capillary network diffusion rate?
What is the estimated total body capillary network diffusion rate?
In a capillary network, what is the primary role of the lymphatic system regarding fluid?
In a capillary network, what is the primary role of the lymphatic system regarding fluid?
What is the net pressure for fluid movement at the venous end of a capillary?
What is the net pressure for fluid movement at the venous end of a capillary?
Flashcards
Closed circulatory system
Closed circulatory system
A type of circulatory system where blood is pumped by a heart but remains within vessels, never directly contacting the tissues.
Main function of the blood system
Main function of the blood system
Involves the delivery of oxygen and nutrients to cells and the removal of waste products like carbon dioxide.
Capillaries
Capillaries
The smallest blood vessels where exchange of substances occurs between blood and tissues.
Arteries
Arteries
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Veins
Veins
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Open circulatory system
Open circulatory system
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Aorta
Aorta
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Vena Cava
Vena Cava
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Vasomotion
Vasomotion
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Capillary Exchange
Capillary Exchange
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Sinusoids
Sinusoids
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Preferential Channel
Preferential Channel
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Plasma
Plasma
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Elastic Artery (Aorta)
Elastic Artery (Aorta)
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Muscular Arteries
Muscular Arteries
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Vasa Vasorum
Vasa Vasorum
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Metarteriole
Metarteriole
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Precapillary Sphincter
Precapillary Sphincter
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Capillary Bed
Capillary Bed
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CD31
CD31
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Capillary Hydrostatic Pressure
Capillary Hydrostatic Pressure
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Plasma Colloid Osmotic Pressure
Plasma Colloid Osmotic Pressure
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Interstitial Fluid Pressure
Interstitial Fluid Pressure
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Interstitial Fluid Colloid Osmotic Pressure
Interstitial Fluid Colloid Osmotic Pressure
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Net Filtration Pressure
Net Filtration Pressure
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Filtration
Filtration
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Diffusion
Diffusion
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Lymphatic System
Lymphatic System
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What is the lymphatic system?
What is the lymphatic system?
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What are lymphatic capillaries?
What are lymphatic capillaries?
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What are lymph nodes?
What are lymph nodes?
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What is Lymph?
What is Lymph?
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How does the lymphatic system work with the circulatory system?
How does the lymphatic system work with the circulatory system?
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Fluid Exchange in Capillaries
Fluid Exchange in Capillaries
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Fluid Exchange
Fluid Exchange
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Albumin
Albumin
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Plasma Proteins
Plasma Proteins
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Study Notes
Cardiovascular System, Biological Fluids, Renal Function
- CFR.2 The systematic circulation, blood vessels, capillary networks are covered.
- Different types of circulatory systems (open and closed) are discussed.
- Function and histology of blood vessels (arteries, veins, and capillaries) are described.
- Physiology and dynamics of fluid exchange in capillary beds are explained.
Circulatory Systems
- Open systems pump blood to tissues in closed arteries without a venous return (e.g., arthropods).
- Closed systems (e.g., vertebrates) keep blood within vessels; blood is one of several fluid systems in the body.
Fluid Systems in the Body
- Blood vascular system
- Lymphatic system
- Cerebrospinal fluid
- Coelomic/Peritoneal fluid
- Interstitial fluid
Blood Vascular System
- The blood system transports materials for metabolism/synthesis and waste products.
- Oxygen and nutrients are supplied to cells; carbon dioxide and other wastes are removed.
- Blood vessels (arteries, capillaries, and veins) carry out transport; distinctions are not sharp.
- No sharp boundaries between blood cells, vessel walls, and other tissues
- Blood vessels transition from aorta to arteries to arterioles to capillaries to venules to veins to vena cava.
Blood Vessels - Histology
- Blood vessels are living, growing structures adapting to tissue needs.
- Arteries and veins have three layers: tunica intima, tunica media, and tunica adventitia/externa.
- Different layers vary in composition and thickness depending on the vessel type (arteries vs veins) and size.
Arteries - Histology
- Large arteries (e.g., aorta) have a thick tunica media mostly composed of elastic tissue.
- Medium-sized arteries (muscular arteries) have less elastic tissue and more smooth muscle.
Veins - Valves
- Veins have valves to prevent blood backflow.
Vasa Vasorum
- Small blood vessels within larger vessel walls supply the connective tissue.
Capillary Networks
- Capillaries are the smallest vessels, formed by a single layer of endothelial cells, usually 8-12 μm, but can be as small as 3 μm.
- They are arranged in beds, are not continuous, and only about 5% of blood volume is in them at any given time.
- Blood flows through capillaries via sphincters.
Capillary Beds
- Estimated to be 10 billion capillaries in the body.
- Most cells are within 20-30 μm of a capillary.
- Blood flow is not continuous in all capillary beds of organs.
- There are preferential channels from arterial to venous sides.
Capillaries
- Non-fenestrated capillaries have low permeability; fenestrated have small pores; and discontinuous have large gaps.
- They vary depending on their need to exchange substances.
Physiology - Capillary Dynamics
- Few cells are in direct contact with capillaries.
- Most cells obtain nutrients and oxygen through the interstitial fluid.
- Blood volume is about 8% of body weight (5-6 L in males, 4-5 L in females).
Physiology - Vasomotion
- Metarterioles and precapillary sphincters are not innervated, causing blood flow to be intermittent in capillary beds.
- Vasomotion is regulated by auto-regulation of oxygen levels in local tissues; tissues with high oxygen levels will have constricted capillaries and the opposite will occur with low oxygen.
Blood
- Blood consists of plasma and blood cells.
- Plasma is a watery fluid containing 8% solids (mostly proteins) and 92% water.
- Blood can be separated into plasma and cellular components by centrifugation.
Physiology – Blood, Plasma, and Capillary Dynamics
- Plasma proteins include albumin, globulins, and fibrinogen (with their amounts specified).
Physiology - Capillary Dynamics
- Major blood vessels are water-tight; fluid does not leak out easily.
- However, fluid leaves arterial capillaries due to blood pressure (hydrostatic pressure).
- Most filtered fluid returns to capillaries due to osmotic pressure of proteins.
- Fluid exchange across capillary walls is filtration and absorption.
Physiology - Fluid Exchange
- Four pressures regulate fluid exchange: capillary hydrostatic pressure, plasma colloid osmotic pressure, interstitial fluid pressure, and interstitial fluid colloid osmotic pressure.
- Capillary hydrostatic pressure forces fluid out of capillaries; plasma colloid osmotic pressure draws fluid back in.
Fluid Exchange
- Net body filtration rate is 1.7-3.5 ml/min or 2.5-5.0 L/day.
- Diffusion occurs in both directions.
- 10% of filtered fluid (about 240L/min) is not reabsorbed into venous capillaries and is passed to the lymphatic system.
Overview of the Systemic Blood Circulation and the Lymphatic System
- Fluid left over in interstitial tissue after exchange processes must return to the circulation.
- This return is collected via blind-starting lymphatic capillaries; this must be monitored as inflammation can occur in tissues.
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