Human Circulatory System Overview
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Questions and Answers

What is the main function of the hepatic portal vein in the human circulatory system?

To carry blood from the gastrointestinal tract and spleen to the liver.

Define the term 'arterial pulse' and describe how it is measured.

Arterial pulse refers to the alternating expansion and recoil of blood vessel walls as the heart beats, measured at superficial arteries.

What are the primary components that determine blood pressure in the circulatory system?

Blood pressure is determined by the force exerted by circulating blood on the vessel walls and the resistance of the blood vessels.

How does the inferior vena cava function in the cardiovascular system?

<p>The inferior vena cava carries deoxygenated blood from the lower body back to the heart.</p> Signup and view all the answers

Explain the significance of measuring respiratory rate as part of vital signs.

<p>Respiratory rate indicates lung function and overall respiratory health, reflecting the body's metabolic activity.</p> Signup and view all the answers

Identify the blood vessels where a pulse can be most easily palpated and explain their significance.

<p>Pulse can be easily palpated in arteries like the radial, carotid, and femoral, significant for assessing heart rate and circulatory health.</p> Signup and view all the answers

Discuss the role of the spleen in relation to the hepatic portal system.

<p>The spleen filters blood and produces immune responses, with its veins draining into the hepatic portal vein.</p> Signup and view all the answers

What is the normal resting heart rate range in a healthy individual, and how does it relate to cardiovascular health?

<p>The normal resting heart rate range is 70 to 76 beats per minute, indicating good cardiovascular fitness.</p> Signup and view all the answers

What is the role of the sympathetic nervous system during a crisis stressor?

<p>It increases heart rate and contractile force to enhance cardiac output.</p> Signup and view all the answers

How do changes in blood volume influence venous return?

<p>Decreased blood volume reduces venous return, while increased blood volume enhances it.</p> Signup and view all the answers

Describe the function of capillary beds in the circulatory system.

<p>Capillary beds facilitate the exchange of nutrients and waste between tissues and blood.</p> Signup and view all the answers

What hormonal changes occur when the crisis has passed?

<p>There is a decrease in epinephrine and thyroxine, leading to a reduction in sympathetic activity.</p> Signup and view all the answers

What are the primary vessels involved in transporting blood away from the heart?

<p>Arteries and arterioles transport blood away from the heart.</p> Signup and view all the answers

How does exercise impact blood pressure and cardiac output?

<p>Exercise typically increases blood pressure and enhances cardiac output due to increased sympathetic activity.</p> Signup and view all the answers

Explain the effect of the vagus nerve on heart function.

<p>The vagus nerve, part of the parasympathetic system, decreases heart rate and promotes relaxation.</p> Signup and view all the answers

What is the relationship between stroke volume and cardiac output?

<p>Cardiac output is the product of stroke volume and heart rate; higher stroke volume leads to greater cardiac output.</p> Signup and view all the answers

What is the primary mechanism by which oxygen and nutrients are exchanged between blood and tissue cells?

<p>The primary mechanism is diffusion, where substances move along concentration gradients.</p> Signup and view all the answers

Explain how blood pressure and osmotic pressure influence fluid movement at capillary beds.

<p>Blood pressure forces fluid and solutes out of capillaries, while osmotic pressure draws fluid into capillaries.</p> Signup and view all the answers

List the four routes through which substances can diffuse into and out of capillaries.

<ol> <li>Direct diffusion through membranes, 2. Diffusion through intercellular clefts, 3. Diffusion through pores of fenestrated capillaries, 4. Transport via vesicles.</li> </ol> Signup and view all the answers

What role does interstitial fluid play in the exchange of substances between blood and tissue?

<p>Interstitial fluid acts as the medium through which gases and nutrients diffuse between blood and tissue cells.</p> Signup and view all the answers

How do concentration gradients affect the movement of carbon dioxide and other waste products from tissue cells to the blood?

<p>Carbon dioxide and wastes move from tissue cells to the blood due to established concentration gradients favoring diffusion toward lower concentration areas.</p> Signup and view all the answers

Describe the significance of fenestrated capillaries in the context of nutrient and gas exchange.

<p>Fenestrated capillaries have pores that allow for increased permeability and rapid exchange of nutrients and gases.</p> Signup and view all the answers

In what way does direct diffusion through membranes differ from other diffusion mechanisms in capillaries?

<p>Direct diffusion occurs across the phospholipid bilayer of cell membranes, while other mechanisms involve gaps or pores in the capillary wall.</p> Signup and view all the answers

Discuss the impact of blood pressure regulation on overall tissue health and function.

<p>Proper blood pressure regulation ensures adequate blood flow and nutrient delivery to tissues, maintaining their health and function.</p> Signup and view all the answers

What initiates each heartbeat in the intrinsic conduction system of the heart?

<p>The sinoatrial (SA) node initiates each heartbeat.</p> Signup and view all the answers

Describe the pathway of the electrical impulse from the SA node to the ventricles.

<p>The impulse travels from the SA node to the AV node, is delayed briefly, then passes through the AV bundle, bundle branches, and Purkinje fibers to stimulate ventricular contraction.</p> Signup and view all the answers

What role does the Atrioventricular (AV) node play in the conduction system of the heart?

<p>The AV node serves to delay the electrical impulse from the atria before it moves to the ventricles.</p> Signup and view all the answers

What are the Purkinje fibers and where are they located?

<p>Purkinje fibers are specialized conductive fibers located within the ventricle wall muscles.</p> Signup and view all the answers

What is the significance of the AV bundle (bundle of His) in the heart's conduction system?

<p>The AV bundle transmits the electrical impulse from the AV node to the bundle branches and then to the Purkinje fibers.</p> Signup and view all the answers

What does it mean when the blood pressure cuff is inflated above 120 mm Hg?

<p>The brachial artery is occluded, preventing blood flow into the arm.</p> Signup and view all the answers

Why can no sounds be heard when the cuff pressure is above 120 mm Hg?

<p>The occlusion stops the blood flow, eliminating any sounds from the brachial artery.</p> Signup and view all the answers

What is the significance of feeling no brachial pulse when the cuff is inflated?

<p>It confirms that the cuff pressure is sufficient to temporarily close the artery.</p> Signup and view all the answers

What happens when the cuff pressure is released gradually?

<p>Blood starts to flow again, and Korotkoff sounds may be heard as the systolic pressure is reached.</p> Signup and view all the answers

What does wrapping the cuff snugly around the arm ensure during measurement?

<p>It ensures accurate pressure application on the brachial artery to obtain reliable readings.</p> Signup and view all the answers

How does Starling’s law of the heart influence stroke volume (SV)?

<p>According to Starling's law, increased stretching of cardiac muscle leads to stronger contractions, thereby increasing stroke volume.</p> Signup and view all the answers

What are the primary neural controls modifying heart rate and their effects?

<p>The sympathetic nervous system speeds up heart rate, while the parasympathetic nervous system, mainly via the vagus nerve, slows it down.</p> Signup and view all the answers

Explain the role of the muscular pump in regulating venous return.

<p>The muscular pump aids in venous return by facilitating blood flow back to the heart through muscle contractions during movement.</p> Signup and view all the answers

Discuss how physical factors influence heart rate variability.

<p>Physical factors such as age, gender, exercise, and body temperature can lead to variations in heart rate due to differing metabolic demands.</p> Signup and view all the answers

What is the impact of hormones like epinephrine on heart rate?

<p>Epinephrine increases heart rate by stimulating the heart, particularly during stress or excitement.</p> Signup and view all the answers

What major arteries supply most of the cerebrum?

<p>The anterior and middle cerebral arteries supply most of the cerebrum.</p> Signup and view all the answers

What structure forms from the joining of the vertebral arteries within the skull?

<p>The basilar artery forms from the joining of the vertebral arteries within the skull.</p> Signup and view all the answers

What physiological changes occur during ventricular systole?

<p>The ventricles contract, intraventricular pressure increases to surpass arterial pressure, opening the semilunar valves and ejecting blood.</p> Signup and view all the answers

What is the significance of isovolumetric relaxation in the cardiac cycle?

<p>It marks the beginning of ventricular diastole where ventricular pressure falls and the semilunar valves close, allowing the heart to prepare for the next heartbeat.</p> Signup and view all the answers

Which arteries form the posterior cerebral arteries?

<p>The posterior cerebral arteries form from the division of the basilar artery.</p> Signup and view all the answers

How are the anterior and posterior blood supplies of the brain connected?

<p>They are connected by small communicating arterial branches.</p> Signup and view all the answers

How are heart sounds produced during the cardiac cycle?

<p>Heart sounds are produced by the closure of the AV valves (lub) and semilunar valves (dup) as blood flows through the heart.</p> Signup and view all the answers

What is the common name for the cerebral arterial circle?

<p>The common name for the cerebral arterial circle is the circle of Willis.</p> Signup and view all the answers

Define cardiac output and explain how it is calculated.

<p>Cardiac output (CO) is the volume of blood pumped by each ventricle per minute, calculated as CO = HR x SV.</p> Signup and view all the answers

What role do heart murmurs play in cardiac health assessment?

<p>Heart murmurs, or abnormal heart sounds, can indicate turbulent blood flow and may suggest underlying heart issues.</p> Signup and view all the answers

Which artery is primarily responsible for supplying the temporal lobe?

<p>The middle cerebral artery is primarily responsible for supplying the temporal lobe.</p> Signup and view all the answers

What role does the anterior communicating artery play in the blood supply to the brain?

<p>The anterior communicating artery connects the left and right anterior cerebral arteries.</p> Signup and view all the answers

What are the typical values for stroke volume and heart rate used in cardiac output calculations?

<p>The typical stroke volume is about 70 ml per contraction, and the average heart rate is around 75 beats per minute.</p> Signup and view all the answers

In the context of the cardiac cycle, what occurs when atrial pressure exceeds intraventricular pressure?

<p>The AV valves open, allowing blood to flow from the atria into the ventricles in preparation for the next contraction.</p> Signup and view all the answers

Which two structures do the internal carotid and vertebral arteries nourish?

<p>The internal carotid arteries nourish the cerebrum, while the vertebral arteries nourish the brain stem and cerebellum.</p> Signup and view all the answers

What is the relationship between blood ejection during ventricular systole and the cardiac cycle events?

<p>Blood ejection occurs during the ventricular systole phase, where the ventricular contraction raises pressure above that in the arteries, opening the semilunar valves.</p> Signup and view all the answers

What is the purpose of the ductus venosus in fetal circulation?

<p>The ductus venosus allows blood to bypass the liver and flow directly into the inferior vena cava.</p> Signup and view all the answers

How does blood flow through the heart change at birth?

<p>At birth, the foramen ovale closes, and blood flow shifts from the right atrium to the right ventricle and into the lungs.</p> Signup and view all the answers

What is the role of the ductus arteriosus during fetal development?

<p>The ductus arteriosus connects the aorta and pulmonary trunk to bypass the non-functioning fetal lungs.</p> Signup and view all the answers

What anatomical structure replaces the foramen ovale after birth?

<p>The foramen ovale becomes the fossa ovalis after birth.</p> Signup and view all the answers

What happens to the ductus arteriosus after birth?

<p>The ductus arteriosus closes and transforms into the ligamentum arteriosum.</p> Signup and view all the answers

Why is it necessary for fetal blood to bypass the lungs?

<p>Fetal blood bypasses the lungs because the fetus receives oxygenated blood through the placenta instead of breathing air.</p> Signup and view all the answers

Which shunt directly links the right atrium to the left atrium in a fetus?

<p>The foramen ovale directly links the right atrium to the left atrium.</p> Signup and view all the answers

How does the ductus venosus contribute to fetal circulation?

<p>The ductus venosus facilitates the transfer of oxygen-rich blood from the placenta directly into the inferior vena cava.</p> Signup and view all the answers

What is the function of the brachiocephalic trunk in the human circulatory system?

<p>The brachiocephalic trunk supplies blood to the right arm and the head, branching into the right common carotid artery and right subclavian artery.</p> Signup and view all the answers

Describe the path that blood takes from the right atrium to the lungs.

<p>Blood flows from the right atrium into the right ventricle, then through the pulmonary trunk to the right and left pulmonary arteries leading to the lungs.</p> Signup and view all the answers

How do the left and right coronary arteries differ in their supply to the heart?

<p>The left coronary artery supplies blood to the left atrium and ventricle, while the right coronary artery primarily supplies the right atrium and ventricle.</p> Signup and view all the answers

What is the role of the ligamentum arteriosum in the anatomy of the heart?

<p>The ligamentum arteriosum is a remnant of the ductus arteriosus, which connects the pulmonary trunk and aortic arch in fetal circulation.</p> Signup and view all the answers

Explain the significance of the apex of the heart.

<p>The apex of the heart is the pointed end of the heart where the left ventricle is located, and it plays a key role in the contraction and pumping efficiency of the heart.</p> Signup and view all the answers

What is the primary purpose of capillary beds in the lungs?

<p>To facilitate gas exchange between oxygen and carbon dioxide.</p> Signup and view all the answers

Explain the difference between pulmonary arteries and pulmonary veins.

<p>Pulmonary arteries carry oxygen-poor blood from the heart to the lungs, while pulmonary veins return oxygen-rich blood from the lungs to the heart.</p> Signup and view all the answers

What role does the left atrium play in the pulmonary circuit?

<p>The left atrium receives oxygen-rich blood from the pulmonary veins after gas exchange in the lungs.</p> Signup and view all the answers

How does the systemic circuit differ from the pulmonary circuit?

<p>The systemic circuit transports oxygen-rich blood to body tissues, whereas the pulmonary circuit carries oxygen-poor blood to the lungs for oxygenation.</p> Signup and view all the answers

Identify the significance of the venae cavae in the circulatory system.

<p>The venae cavae are crucial for returning oxygen-poor blood from the body back to the right atrium of the heart.</p> Signup and view all the answers

What is the primary function of capillary beds found throughout the body's tissues?

<p>To facilitate the exchange of gases, nutrients, and waste products between blood and tissue cells.</p> Signup and view all the answers

Describe how the aorta is connected to the systemic circuit.

<p>The aorta distributes oxygen-rich blood from the left ventricle to the systemic circuit to supply the rest of the body.</p> Signup and view all the answers

Explain the relationship between the heart's right ventricle and the pulmonary arteries.

<p>The right ventricle pumps oxygen-poor blood into the pulmonary arteries, directing it to the lungs for gas exchange.</p> Signup and view all the answers

What are the two types of blood pressure measured during the cardiac cycle?

<p>Systolic and diastolic pressure.</p> Signup and view all the answers

Explain the blood pressure gradient as blood travels away from the heart.

<p>Blood pressure decreases as the distance from the heart increases.</p> Signup and view all the answers

How is blood pressure typically expressed in clinical settings?

<p>As systolic pressure over diastolic pressure in millimeters of mercury (mm Hg).</p> Signup and view all the answers

What does an indirect method of measuring systemic arterial blood pressure involve?

<p>It often uses the auscultatory method in the brachial artery.</p> Signup and view all the answers

What physiological process causes blood to flow from the arteries to the veins?

<p>Blood flows along a descending pressure gradient.</p> Signup and view all the answers

What occurs during the ejection phase of ventricular systole?

<p>The ventricles continue to contract, intraventricular pressure surpasses the pressure in major arteries, and blood is ejected from the ventricles as the semilunar valves open.</p> Signup and view all the answers

Describe the events that characterize isovolumetric relaxation.

<p>During isovolumetric relaxation, ventricles begin diastole, pressure falls below arterial pressure, and semilunar valves close, making the ventricles temporarily closed chambers.</p> Signup and view all the answers

Describe the relationship between systolic and diastolic pressure.

<p>Systolic pressure is higher due to ventricular contraction, while diastolic pressure is lower during relaxation.</p> Signup and view all the answers

What are the characteristics of the 'Lub' and 'Dup' heart sounds?

<p>'Lub' is a longer, louder sound due to the closing of AV valves, while 'Dup' is a shorter, sharper sound from the closure of semilunar valves.</p> Signup and view all the answers

What happens to the blood pressure as it enters the capillaries?

<p>Blood pressure decreases significantly.</p> Signup and view all the answers

How is cardiac output (CO) calculated, and what are its normal values?

<p>Cardiac output is calculated as CO = HR x SV; with typical values around 5.25 L/min, based on a heart rate of 75 beats/min and a stroke volume of 70 ml/beat.</p> Signup and view all the answers

What is the significance of measuring blood pressure regularly?

<p>It helps assess cardiovascular health and identify potential issues.</p> Signup and view all the answers

What does turbulent blood flow indicate, and how is it related to heart murmurs?

<p>Turbulent blood flow can indicate a potential underlying heart problem, and it produces sounds known as heart murmurs.</p> Signup and view all the answers

Explain the role of atrial pressure in relation to intraventricular pressure during the cardiac cycle.

<p>Atrial pressure must increase above intraventricular pressure for the AV valves to open, allowing blood to flow from the atria to the ventricles.</p> Signup and view all the answers

What is the stroke volume (SV), and how much blood is typically pumped from the left ventricle each heartbeat?

<p>Stroke volume is the volume of blood pumped by each ventricle per contraction, typically around 70 ml for the left ventricle.</p> Signup and view all the answers

During which phase of the cardiac cycle are the ventricles fully closed chambers, and what is its significance?

<p>During isovolumetric relaxation, the ventricles become fully closed chambers, allowing pressure to decrease before they refill with blood.</p> Signup and view all the answers

What does a blood pressure cuff reading of 120 mm Hg signify during measurement?

<p>It signifies the systolic pressure, the pressure at which the first sounds are heard.</p> Signup and view all the answers

At what pressure is no sound audible in the stethoscope when measuring blood pressure?

<p>No sound is audible when the pressure in the cuff is below 70 mm Hg.</p> Signup and view all the answers

Describe the significance of the first soft tapping sounds heard during blood pressure measurement.

<p>These sounds indicate the transition from no blood flow to blood spurting through the constricted artery.</p> Signup and view all the answers

What happens to the sounds detected by the stethoscope as the cuff pressure is gradually released past the systolic level?

<p>The sounds become louder and more distinct until blood flows freely and the sounds disappear.</p> Signup and view all the answers

What physiological state is represented by a cuff pressure below 70 mm Hg?

<p>It represents a state where the artery is completely open, with no constriction remaining.</p> Signup and view all the answers

How is systolic pressure measured using a stethoscope during the blood pressure assessment?

<p>Systolic pressure is measured when the first soft tapping sounds are heard as cuff pressure is reduced.</p> Signup and view all the answers

What is the role of the stethoscope in blood pressure measurement?

<p>The stethoscope is used to auscultate sounds in the brachial artery indicating blood flow.</p> Signup and view all the answers

Why is it important to monitor the pressure range of 70 mm Hg to 120 mm Hg during blood pressure assessment?

<p>This range is crucial for accurately determining systolic and diastolic pressures and assessing cardiovascular health.</p> Signup and view all the answers

What dietary components are commonly believed to prevent hypertension?

<p>A diet low in salt, saturated fats, and cholesterol is believed to prevent hypertension.</p> Signup and view all the answers

What is the normal systolic blood pressure range for humans?

<p>The normal systolic pressure ranges from 110 to 140 mm Hg.</p> Signup and view all the answers

Define hypotension and its associated systolic blood pressure threshold.

<p>Hypotension is defined as low blood pressure, specifically a systolic reading below 100 mm Hg.</p> Signup and view all the answers

What constitutes hypertension, and what systolic and diastolic readings define it?

<p>Hypertension is sustained elevated arterial pressure of 140/90 mm Hg or higher.</p> Signup and view all the answers

How do chemicals like renin affect blood pressure?

<p>Chemicals such as renin increase blood viscosity and contribute to vasoconstriction, leading to elevated blood pressure.</p> Signup and view all the answers

What role does the sympathetic nervous system play concerning blood pressure?

<p>The sympathetic nervous system stimulates increased heart rate and stroke volume, thereby increasing blood pressure.</p> Signup and view all the answers

What physiological changes occur that lead to increased cardiac output?

<p>Increased stroke volume and heart rate result in elevated cardiac output.</p> Signup and view all the answers

Explain the significance of postural changes in blood pressure regulation.

<p>Postural changes can affect blood volume distribution, impacting blood pressure and potentially leading to orthostatic hypotension.</p> Signup and view all the answers

Study Notes

Cardiovascular System

  • A closed system of the heart and blood vessels
  • The heart pumps blood
  • Blood vessels allow blood to circulate to all parts of the body
  • Functions of the cardiovascular system include transporting oxygen, nutrients, cell wastes, and hormones to and from cells

Anatomy of the Heart

  • Size of a human fist, weighing less than a pound
  • Located in the thoracic cavity, between the lungs in the inferior mediastinum
  • Orientation:
    • Apex is directed toward the left hip and rests on the diaphragm
    • Base points toward the right shoulder

Coverings of the Heart

  • Pericardium-a double-walled sac
    • Fibrous pericardium is loose and superficial
    • Serous membrane is deep to the fibrous pericardium and composed of two layers:
        1. Parietal pericardium: outside layer that lines the inner surface of the fibrous pericardium
        1. Visceral pericardium: next to heart; also known as the epicardium
  • Serous fluid fills the space between the layers of pericardium, called the pericardial cavity

Functions of the Pericardium

  • Keeps the heart contained within the chest cavity
  • Prevents the heart from overexpanding when blood volume increases
  • Limits heart motion
  • Reduces friction between the heart and surrounding tissues
  • Protects the heart against infection

Walls of the Heart

  1. Epicardium (Pericardium):
    • Outside layer; the visceral pericardium
  2. Myocardium:
    • Middle layer; the thickest layer
    • Mostly cardiac muscle
    • The layer that contracts
  3. Endocardium:
    • Inner layer known as endothelium
    • Lines the inner heart chambers, covers heart valves and continuous with the endothelium of large blood vessels

Chambers and Associated Great Vessels

  • Four chambers of the heart:
    • Atria (right and left): Receiving chambers, assist with filling the ventricles, blood enters under low pressure
    • Ventricles (right and left): Discharging chambers, thick-walled pumps of the heart, during contraction, blood is propelled into circulation
  • Interatrial septum: Separates the two atria longitudinally
  • Interventricular septum: Separates the two ventricles longitudinally

Heart Valves

  • Allow blood to flow in only one direction, preventing backflow
  • Valves open and close in response to pressure changes in the heart
  • Atrioventricular (AV) valves-between atria and ventricles:
    • Left AV valve: bicuspid (mitral) valve
    • Right AV valve: tricuspid valve
    • Function: Anchored by chordae tendineae to the walls of the ventricles. Open during heart relaxation, when blood passively fills the chambers. Closed during ventricular contraction
  • Semilunar valves-between ventricle and artery:
    • Pulmonary semilunar valve
    • Aortic semilunar valve
    • Function: Closed during heart relaxation. Open during ventricular contraction

Cardiac Circulation

  • Blood in the heart chambers does not nourish the myocardium
  • The heart has its own nourishing circulatory system consisting of:
    • Coronary arteries: branch from the aorta to supply the heart muscle with oxygenated blood.
    • Cardiac veins: drain the myocardium of blood
    • Coronary sinus: a large vein on the posterior of the heart; receives blood from cardiac veins. Blood empties into the right atrium via the coronary sinus

Gross Anatomy of Blood Vessels

  • Major arteries of systemic circulation:

    • Aorta: Largest artery, leaves from the left ventricle of the heart. Regions include ascending aorta, aortic arch, thoracic aorta, and abdominal aorta
    • Arterial branches of the ascending aorta: Right and left coronary arteries serve the heart
    • Arterial branches of the aortic arch: Brachiocephalic trunk, Right common carotid artery, Right subclavian artery, Left common carotid artery, Left internal and external carotid arteries, Left subclavian artery, Vertebral artery
    • Arterial branches of the thoracic aorta: Intercostal arteries supply the muscles of the thorax wall, Lungs (bronchial arteries), Esophagus (esophageal arteries), Diaphragm (phrenic arteries)
    • Arterial branches of the abdominal aorta: Celiac trunk (left gastric artery, splenic artery, common hepatic artery), Superior mesenteric artery, Left and right renal arteries, Left and right gonadal arteries (ovarian arteries in females, testicular arteries in males), Lumbar arteries
    • Arterial branches of the abdominal aorta (continued): Inferior mesenteric artery, Left and right common iliac arteries, Internal iliac arteries, External iliac arteries, Femoral artery, Popliteal artery, Anterior tibial artery, Posterior tibial artery, Dorsalis pedis artery, Arcuate artery
  • Major veins of systemic circulation:

    • Superior vena cava and inferior vena cava enter the right atrium of the heart, the superior vena cava drains the head and arms, and the inferior vena cava drains the lower body
    • Veins draining into the superior vena cava: Radial and ulnar veins, Cephalic vein, Basilic vein, Subclavian vein, Vertebral vein, Internal jugular vein, Brachiocephalic veins
    • Veins draining into the inferior vena cava: Anterior and posterior tibial veins, Great saphenous veins, Common iliac vein, Internal iliac arteries, External iliac vein, Femoral vein, Popliteal vein, Posterior tibial veins, Anterior tibial vein, Small saphenous vein, Dorsal venous arch, Dorsal metatarsal veins, Hepatic portal vein, Hepatic veins, Splenic vein, Gastric veins, Inferior mesenteric vein, Superior mesenteric vein, Renal veins, Left and right gonadal veins
  • Arterial supply of the brain and the circle of Willis:

    • Internal carotid arteries divide into Anterior and middle cerebral arteries
    • These arteries supply most of the cerebrum
    • Vertebral arteries join to form the Basilar artery
    • Basilar artery serves the brain stem and cerebellum
    • Posterior cerebral arteries are formed from the division of the basilar artery and supply the posterior cerebrum
    • Anterior and posterior blood supplies to the brain are united by small communicating arterial branches which form the cerebral arterial circle, or circle of Willis
  • Hepatic portal circulation:

    • Formed by veins draining the digestive organs which empty into the hepatic portal vein. The digestive organs, spleen, and pancreas drain into the portal vein before draining into the liver

Physiology of Circulation

  • Vital signs: Measurements of arterial pulse, blood pressure, respiratory rate, and body temperature
  • Arterial pulse: Alternate expansion and recoil of a blood vessel wall, where pulse is easily palpated
  • Blood pressure: The pressure the blood exerts against the inner walls of blood vessels, the force that causes blood to continue to flow in the blood vessels
  • Blood pressure gradient: When the ventricles contract, blood is forced into elastic arteries close to the heart, the pressure decreases in the blood vessels as distance from the heart increases. Pressure is high in arteries, lower in capillaries, and lowest in veins
  • Measuring blood pressure: Systolic/diastolic pressure (e.g., 120/80 mm Hg), Auscultatory method
  • Effects of various factors on blood pressure: Factors include cardiac output, peripheral resistence, neural, renal, temperature, chemical, and diet

Capillary Exchange

  • Interstitial fluid (tissue fluid) is found between cells
  • Substances move to and from the blood and tissue cells through capillary walls
  • Exchange is due to concentration gradients
  • Oxygen and nutrients leave the blood and move into tissue cells
  • Carbon dioxide and other wastes exit tissue cells and enter the blood
  • Substances take various routes entering or leaving blood including direct diffusion through membranes, diffusion through intercellular clefts, and diffusion through pores in fenestrated capillaries
  • Fluid moves out of capillaries at the arterial end and is reclaimed at the venous end of the bed and fluid movement is dependent upon blood pressure and osmotic pressure

Developmental Aspects of the Cardiovascular System

  • In an embryo, the heart develops as a simple tube and pumps blood by week 4, becoming a four-chambered organ capable of acting as a double pump over the next 3 week
  • Umbilical cord-Carries nutrients and oxygen from maternal blood to fetal blood. Fetal wastes move from fetal blood to maternal blood. One umbilical vein carries nutrient and oxygen-rich blood to the fetus. Two umbilical arteries carry wastes and carbon dioxide-rich blood from the fetus to the placenta
  • Shunts bypassing the lungs and liver are present in a fetus:
    • Blood flow bypasses the liver through the ductus venosus and enters the inferior vena cava → right atrium of the heart
    • Blood flow bypasses the lungs: Blood entering right atrium is shunted directly into left atrium through the foramen ovale (becomes fossa ovalis at or after birth). Ductus arteriosus connects aorta and pulmonary trunk, becomes ligamentum arteriosum at birth
  • Weakening of venous valves
  • Varicose veins
  • Progressive arteriosclerosis
  • Hypertension
  • Coronary artery disease

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This quiz covers the essential functions and components of the human circulatory system, including the roles of various blood vessels, the hepatic portal vein, and the significance of vital signs. Test your knowledge on blood pressure determinants, heart rate norms, and the impact of the sympathetic nervous system.

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