Chronic Inflammation and Pain Signaling Quiz
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Questions and Answers

Which of the following is a fatty acid involved in pain signaling?

  • Stearic acid
  • Arachidonic acid (correct)
  • Palmitic acid
  • Linoleic acid
  • What type of receptor do NSAIDs bind to in order to exert their analgesic effect?

  • Tyrosine kinase receptor
  • Ion channel receptor
  • Nuclear receptor
  • G protein-coupled receptor (correct)
  • Which of the following is a specific inhibitor of the cyclooxygenase pathway?

  • Paracetamol
  • Celecoxib (correct)
  • Aspirin
  • Ibuprofen
  • Which of the following is NOT a component of the complement pathway?

    <p>IL-8 (D)</p> Signup and view all the answers

    Which of the following is a product of the lipoxygenase pathway?

    <p>Leukotriene B4 (B)</p> Signup and view all the answers

    What is the function of chemoattractants?

    <p>To attract leukocytes to the site of injury (A)</p> Signup and view all the answers

    Why do phagocytic cells not eat up our cells?

    <p>Phagocytic cells are programmed not to engulf the body's own cells (B)</p> Signup and view all the answers

    Which of the following is a property of arachidonic acid?

    <p>It is a fatty acid (B)</p> Signup and view all the answers

    Which of the following is a characteristic of chronic inflammation?

    <p>Presence of lymphocytes and macrophages (A)</p> Signup and view all the answers

    Which of the following is a key mediator of chronic inflammation?

    <p>Cytokines (C)</p> Signup and view all the answers

    What is the primary function of macrophages in chronic inflammation?

    <p>Destroy foreign invaders and damaged tissues (A)</p> Signup and view all the answers

    Which of the following is a characteristic of a granuloma?

    <p>An accumulation of lymphocytes and macrophages around a central core (A)</p> Signup and view all the answers

    Which of the following conditions is associated with a buildup of fat in blood vessels and narrowing of the vessels?

    <p>Atherosclerosis (B)</p> Signup and view all the answers

    What is the role of T-helper cells in chronic inflammation?

    <p>Signal other cells about the ongoing inflammation (C)</p> Signup and view all the answers

    Which of the following is a potential consequence of prolonged exposure to toxins?

    <p>Carcinogenesis (A)</p> Signup and view all the answers

    Which of the following cells is NOT a key player in chronic inflammation?

    <p>Neutrophils (D)</p> Signup and view all the answers

    What is the primary role of growth factors in tissue repair?

    <p>To stimulate the growth and proliferation of cells. (D)</p> Signup and view all the answers

    Which of the following is a key factor that influences the success of tissue regeneration?

    <p>The type of injury and its severity. (C)</p> Signup and view all the answers

    What is the main type of cell that is responsible for producing growth factors during tissue repair?

    <p>Macrophages (A)</p> Signup and view all the answers

    What is the role of the extracellular matrix (ECM) in tissue regeneration?

    <p>It provides a structural scaffold for cells to adhere to. (A)</p> Signup and view all the answers

    What is the specific type of cell that is responsible for scar formation during tissue repair?

    <p>Fibroblasts (D)</p> Signup and view all the answers

    What is the difference between regeneration and scar formation in tissue repair?

    <p>Regeneration involves the formation of new tissue, while scar formation involves the formation of a fibrous mass. (B)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of the process of regeneration in tissue repair?

    <p>Formation of a fibrous scar. (C)</p> Signup and view all the answers

    Which of the following is a key reason why tissue regeneration may not occur in certain types of injuries?

    <p>All of the above. (D)</p> Signup and view all the answers

    What happens in the margins and base of an ulcer during chronicity?

    <p>The margins and base develop inflammation, scar tissue formation, and an increase in lymphocytes, macrophages, and plasma cells. (D)</p> Signup and view all the answers

    What can happen if an ulcer perforates a hollow organ, such as the duodenum?

    <p>The contents of the organ will leak into the surrounding tissue, leading to inflammation. (C)</p> Signup and view all the answers

    What is the reason for the intense polymorphonuclear infiltration during the acute stage of an ulcer?

    <p>The release of inflammatory mediators by damaged tissue cells. (A)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of chronic inflammation in ulceration?

    <p>Intense polymorphonuclear infiltration (C)</p> Signup and view all the answers

    What immune response is responsible for tuberculosis (TB)?

    <p>Type IV hypersensitivity reaction (A)</p> Signup and view all the answers

    What makes it difficult for macrophages to effectively digest and degrade Mycobacteria?

    <p>The bacteria's waxy or lipid coating (A)</p> Signup and view all the answers

    What characteristic differentiates hypersensitivity reactions from allergic reactions?

    <p>Hypersensitivity reactions often involve the activation of T cells, while allergic reactions are primarily mediated by IgE antibodies. (B)</p> Signup and view all the answers

    What is a characteristic of hypersensitivity diseases, such as rheumatoid arthritis and multiple sclerosis?

    <p>These diseases involve the immune system attacking the body's own tissues. (B)</p> Signup and view all the answers

    What is a common characteristic of both acute and chronic inflammation?

    <p>They both involve an attempt by the body to repair injured tissue (B)</p> Signup and view all the answers

    What is an example of an exogenous toxin that can contribute to chronic inflammation?

    <p>Silica particles inhaled into the lungs (C)</p> Signup and view all the answers

    What is the main mechanism by which chronic inflammation attempts to heal injured tissue?

    <p>Formation of scar tissue through connective tissue deposition (C)</p> Signup and view all the answers

    What characteristic distinguishes a hypersensitivity reaction from a typical inflammatory response?

    <p>Hypersensitivity reactions involve an exaggerated immune response. (A)</p> Signup and view all the answers

    What is the role of an antigen in a hypersensitivity reaction?

    <p>To stimulate the immune system to produce antibodies (B)</p> Signup and view all the answers

    How can chronic inflammation contribute to the development of systemic lupus erythematosus?

    <p>By creating conditions that favor the formation of antigen-antibody complexes (A)</p> Signup and view all the answers

    Which of these is NOT a characteristic of chronic inflammation?

    <p>It is always accompanied by a fever and pain. (D)</p> Signup and view all the answers

    How is the process of angiogenesis relevant to chronic inflammation?

    <p>It promotes the formation of new blood vessels, supporting the repair process. (C)</p> Signup and view all the answers

    Which of these are characteristic of granulation tissue?

    <p>Abundant thin-walled capillaries and inflammatory cells. (B)</p> Signup and view all the answers

    What is the main reason why cancer cells induce angiogenesis?

    <p>To provide an adequate blood supply. (B)</p> Signup and view all the answers

    According to the provided text, how do collagen supplements or drinks potentially benefit skin health?

    <p>They provide essential amino acids that can be used for collagen production in the skin. (C)</p> Signup and view all the answers

    What is the primary role of mononuclear leukocytes (macrophages and lymphocytes) in granulation tissue?

    <p>They help remove cellular debris and fight infection. (B)</p> Signup and view all the answers

    What is the proposed mechanism of action for microneedling treatments like the Diamond Peel?

    <p>They induce a controlled wound response, promoting collagen formation. (A)</p> Signup and view all the answers

    Which of the following is a characteristic seen on a histological preparation of granulation tissue?

    <p>Thin-walled blood vessels with red blood cells inside. (A)</p> Signup and view all the answers

    What is the significance of the statement "the cancer cells will die"?

    <p>By inhibiting angiogenesis, the tumor cells are deprived of a vital blood supply, leading to their death. (D)</p> Signup and view all the answers

    What is the role of carbohydrates in promoting healthy skin?

    <p>They supply energy to skin cells, supporting their metabolic functions. (C)</p> Signup and view all the answers

    Flashcards

    Arachidonic Acid

    A fatty acid chain that plays a key role in pain signaling.

    Cytokines

    Chemical messengers released by cells in response to injury.

    Cyclooxygenase Pathway

    Pathway for converting arachidonic acid into prostaglandins.

    Leukotriene B4

    A metabolite of arachidonic acid involved in promoting inflammation.

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    NSAIDs

    Non-steroidal anti-inflammatory drugs that inhibit pain pathways.

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    COX Inhibitors

    Medications that specifically block the cyclooxygenase enzymes.

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    Analgesics

    Substances that relieve pain without causing anesthesia.

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    Phagocytic Cells

    Cells that engulf and digest pathogens but avoid healthy cells.

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    Chronic Ulcer

    A long-standing sore that develops fibroblastic proliferation and scarring.

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    Fibroblastic Proliferation

    Increased growth of fibroblasts leading to tissue repair and scarring.

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    Type IV Hypersensitivity Reaction

    A delayed immune response characterized by tissue damage due to immune cell activation.

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    Perforation of Organ

    A serious complication where an ulcer causes a hole in a hollow organ.

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    Peritonitis

    Inflammation of the peritoneum caused by leakage of organ contents, often due to perforation.

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    Autoimmune Conditions

    Diseases where the immune system attacks the body’s own tissues, leading to chronic inflammation.

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    Polymorphonuclear Infiltration

    Accumulation of various white blood cells at the site of injury or infection.

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    Hypersensitivity vs Allergy

    Hypersensitivity is an exaggerated immune response, while an allergy is a specific hypersensitivity to allergens.

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    Fibroblasts

    Cells that create connective tissue and scarring in response to injury.

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    Granuloma

    Localized collection of macrophages in chronic inflammation.

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    Atherosclerosis

    Chronic inflammation of arterial walls due to lipid accumulation.

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    Macrophages

    Cells that engulf and digest foreign substances and tissue debris.

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    T-lymphocytes

    Type of white blood cells involved in immune response, including T-helper and T-killer cells.

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    Chronic Inflammation

    A prolonged inflammatory response with tissue destruction and healing.

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    Hematopoietic Stem Cells

    Stem cells that give rise to all blood cells in bone marrow.

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    Persistent Infections

    Infections that are difficult to eradicate, often leading to chronic inflammation.

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    Hypersensitivity Reactions

    Exaggerated immune responses to antigens, leading to tissue damage.

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    Antigens

    Substances that evoke an immune response, prompting antibody production.

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    Antibodies

    Proteins produced by the immune system to neutralize or destroy antigens.

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    Antigen-Antibody Complex

    A structure formed when an antibody binds to its specific antigen, potentially leading to tissue damage.

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    Prolonged Exposure to Toxins

    Long-term exposure to harmful substances, resulting in chronic inflammation and tissue damage.

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    Scar Formation

    Replacement of injured tissue with connective tissue during healing, often after chronic inflammation.

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    Cell Proliferation

    The process of cell growth and division, crucial for regeneration.

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    Growth Factors

    Proteins that stimulate cell growth and tissue repair.

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    Extracellular Matrix (ECM)

    A structural network that supports tissue integrity during regeneration.

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    Tissue Repair

    The process involving healing and restoring tissue after injury.

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    Complete Regeneration

    Restoration of tissue to its original structure and function.

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    Angiogenesis

    The process of forming new blood vessels, often seen in cancer cells.

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    Granulation Tissue

    New connective tissue and blood vessels that form during healing.

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    Collagen Formation

    The process where fibroblasts produce collagen for skin repair.

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    Microneedling

    A dermatological procedure that creates micro-injuries to stimulate collagen production.

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    Tertiary Proteins

    Proteins that are often broken down into amino acids when absorbed into the body.

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    Inflammatory Cells

    Cells that respond to injury and infection, including macrophages.

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    Study Notes

    Inflammation and Tissue Repair

    • Inflammation is the body's response to infection or tissue damage
    • The goal is to eliminate the offending agent (e.g., microorganism)
    • Inflammation also leads to tissue repair
    • Mediators include phagocytic leukocytes, antibodies, and complement proteins
    • Inflammation is a positive response, a crucial process for eliminating threats to the body
    • Failure of inflammation can negatively impact the body

    Inflammation: Sequential Events

    • Recognition: The body detects noxious stimuli
    • This is the initiating stimulus

    Causes of Inflammation

    • Infection: Different microorganisms trigger varied inflammatory responses, the resulting damage varies based on many factors.
    • Tissue necrosis: cell death triggers inflammation, regardless of the cause
    • Foreign bodies: elicit inflammation by causing tissue damage
    • Immune reactions: Hypersensitivity reactions where the immune system damages its own tissues

    Acute Inflammation

    • Immediate response to injurious stimuli, blood vessels dilate
    • Increased permeability of vessels allows plasma proteins and leukocytes to move into the injured area
    • Leukocytes migrate to the injured site to eliminate the offending agent
    • Diapedesis: The movement of leukocytes between cells

    Acute Inflammation: Leukocyte Recruitment

    • Increased vascular permeability allows fluid to leak into the injured area
    • Increased blood flow causes swelling and redness (erythema)
    • Slowed blood flow (stasis) causes leukocytes to adhere to the vessel walls (margination)

    Acute Inflammation: Leukocyte Adhesion

    • Selectins mediate initial rolling of leukocytes
    • Integrins slow rolling, aid firm adhesion

    Acute Inflammation: Chemotaxis

    • Chemoattractants signal the migration of leukocytes to the site of injury
    • Chemoattractants can be exogenous (external) or endogenous (internal)

    Acute Inflammation: Phagocytosis

    • Recognition and attachment of the particle (e.g., microorganism) to the leukocyte
    • Engulfment of the particle into the leukocyte (phagocytosis)
    • Killing and degradation of the particle within the leukocyte

    Morphological Patterns: Serous Inflammation

    • Exudation of a fluid poor in cells into spaces or body cavities (e.g., pleural, peritoneal)
    • Fluid is called an effusion if within body cavities

    Morphological Patterns: Fibrinous Inflammation

    • Large vascular leaks, or a large stimulus triggers the formation of a fibrinous material that coagulates
    • Found in lining of body cavities (e.g., meninges)

    Morphological Patterns: Purulent Inflammation

    • Exudate contains neutrophils and dead cells (pus)
    • Pus formation often associated with bacterial infection that causes liquefactive necrosis (e.g., Streptococcus)
    • Abscess: a localized collection of pus, often in body cavities

    Morphological Patterns: Ulcers

    • Local defects or excavations of tissue surfaces
    • Often involves chronic inflammation and may be caused by infection, ischemia, or other issues

    Chronic Inflammation

    • Prolonged response, tissue injury and attempts to repair coexist
    • May follow acute injury or begin as slow-progressing issues
    • Often due to persistent infection/toxin exposure
    • Involves macrophages, lymphocytes, and other cells
    • Chronic inflammation leads to tissue damage, scarring (fibrosis), and potential development of diseases

    Chronic Inflammation: Macrophages

    • Central in chronic inflammation
    • Secrete cytokines and growth factors to activate other cells and mediate inflammatory responses

    Tissue Repair

    • Restoration of tissue architecture and function
    • Regeneration: Complete restoration of the structure
    • Scar formation: Connective tissue deposition if regeneration is impossible
    • Healing proceeds in stages, with inflammation often a precursor

    Chronic Inflammation: Causes

    • Persistent infections (e.g., Mycobacteria)
    • Hypersensitivity diseases (e.g., rheumatoid arthritis)

    Wound Healing Mechanisms: Acute and Chronic Injuries

    • Repairing tissues has two pathways: regeneration and scarring
    • Inflammation precedes the healing process
    • Regeneration replaces damaged tissue with identical tissue
    • Scarring replaces damaged tissue with fibrous tissue

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    Test your knowledge on chronic inflammation and its mediators with this quiz. It covers important concepts such as fatty acids involved in pain signaling, the role of receptors, and the function of macrophages. Dive into the mechanisms of inflammation and related conditions.

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