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Questions and Answers
Which of the following is a fatty acid involved in pain signaling?
Which of the following is a fatty acid involved in pain signaling?
What type of receptor do NSAIDs bind to in order to exert their analgesic effect?
What type of receptor do NSAIDs bind to in order to exert their analgesic effect?
Which of the following is a specific inhibitor of the cyclooxygenase pathway?
Which of the following is a specific inhibitor of the cyclooxygenase pathway?
Which of the following is NOT a component of the complement pathway?
Which of the following is NOT a component of the complement pathway?
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Which of the following is a product of the lipoxygenase pathway?
Which of the following is a product of the lipoxygenase pathway?
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What is the function of chemoattractants?
What is the function of chemoattractants?
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Why do phagocytic cells not eat up our cells?
Why do phagocytic cells not eat up our cells?
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Which of the following is a property of arachidonic acid?
Which of the following is a property of arachidonic acid?
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Which of the following is a characteristic of chronic inflammation?
Which of the following is a characteristic of chronic inflammation?
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Which of the following is a key mediator of chronic inflammation?
Which of the following is a key mediator of chronic inflammation?
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What is the primary function of macrophages in chronic inflammation?
What is the primary function of macrophages in chronic inflammation?
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Which of the following is a characteristic of a granuloma?
Which of the following is a characteristic of a granuloma?
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Which of the following conditions is associated with a buildup of fat in blood vessels and narrowing of the vessels?
Which of the following conditions is associated with a buildup of fat in blood vessels and narrowing of the vessels?
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What is the role of T-helper cells in chronic inflammation?
What is the role of T-helper cells in chronic inflammation?
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Which of the following is a potential consequence of prolonged exposure to toxins?
Which of the following is a potential consequence of prolonged exposure to toxins?
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Which of the following cells is NOT a key player in chronic inflammation?
Which of the following cells is NOT a key player in chronic inflammation?
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What is the primary role of growth factors in tissue repair?
What is the primary role of growth factors in tissue repair?
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Which of the following is a key factor that influences the success of tissue regeneration?
Which of the following is a key factor that influences the success of tissue regeneration?
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What is the main type of cell that is responsible for producing growth factors during tissue repair?
What is the main type of cell that is responsible for producing growth factors during tissue repair?
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What is the role of the extracellular matrix (ECM) in tissue regeneration?
What is the role of the extracellular matrix (ECM) in tissue regeneration?
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What is the specific type of cell that is responsible for scar formation during tissue repair?
What is the specific type of cell that is responsible for scar formation during tissue repair?
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What is the difference between regeneration and scar formation in tissue repair?
What is the difference between regeneration and scar formation in tissue repair?
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Which of the following is NOT a characteristic of the process of regeneration in tissue repair?
Which of the following is NOT a characteristic of the process of regeneration in tissue repair?
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Which of the following is a key reason why tissue regeneration may not occur in certain types of injuries?
Which of the following is a key reason why tissue regeneration may not occur in certain types of injuries?
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What happens in the margins and base of an ulcer during chronicity?
What happens in the margins and base of an ulcer during chronicity?
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What can happen if an ulcer perforates a hollow organ, such as the duodenum?
What can happen if an ulcer perforates a hollow organ, such as the duodenum?
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What is the reason for the intense polymorphonuclear infiltration during the acute stage of an ulcer?
What is the reason for the intense polymorphonuclear infiltration during the acute stage of an ulcer?
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Which of the following is NOT a characteristic of chronic inflammation in ulceration?
Which of the following is NOT a characteristic of chronic inflammation in ulceration?
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What immune response is responsible for tuberculosis (TB)?
What immune response is responsible for tuberculosis (TB)?
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What makes it difficult for macrophages to effectively digest and degrade Mycobacteria?
What makes it difficult for macrophages to effectively digest and degrade Mycobacteria?
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What characteristic differentiates hypersensitivity reactions from allergic reactions?
What characteristic differentiates hypersensitivity reactions from allergic reactions?
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What is a characteristic of hypersensitivity diseases, such as rheumatoid arthritis and multiple sclerosis?
What is a characteristic of hypersensitivity diseases, such as rheumatoid arthritis and multiple sclerosis?
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What is a common characteristic of both acute and chronic inflammation?
What is a common characteristic of both acute and chronic inflammation?
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What is an example of an exogenous toxin that can contribute to chronic inflammation?
What is an example of an exogenous toxin that can contribute to chronic inflammation?
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What is the main mechanism by which chronic inflammation attempts to heal injured tissue?
What is the main mechanism by which chronic inflammation attempts to heal injured tissue?
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What characteristic distinguishes a hypersensitivity reaction from a typical inflammatory response?
What characteristic distinguishes a hypersensitivity reaction from a typical inflammatory response?
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What is the role of an antigen in a hypersensitivity reaction?
What is the role of an antigen in a hypersensitivity reaction?
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How can chronic inflammation contribute to the development of systemic lupus erythematosus?
How can chronic inflammation contribute to the development of systemic lupus erythematosus?
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Which of these is NOT a characteristic of chronic inflammation?
Which of these is NOT a characteristic of chronic inflammation?
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How is the process of angiogenesis relevant to chronic inflammation?
How is the process of angiogenesis relevant to chronic inflammation?
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Which of these are characteristic of granulation tissue?
Which of these are characteristic of granulation tissue?
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What is the main reason why cancer cells induce angiogenesis?
What is the main reason why cancer cells induce angiogenesis?
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According to the provided text, how do collagen supplements or drinks potentially benefit skin health?
According to the provided text, how do collagen supplements or drinks potentially benefit skin health?
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What is the primary role of mononuclear leukocytes (macrophages and lymphocytes) in granulation tissue?
What is the primary role of mononuclear leukocytes (macrophages and lymphocytes) in granulation tissue?
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What is the proposed mechanism of action for microneedling treatments like the Diamond Peel?
What is the proposed mechanism of action for microneedling treatments like the Diamond Peel?
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Which of the following is a characteristic seen on a histological preparation of granulation tissue?
Which of the following is a characteristic seen on a histological preparation of granulation tissue?
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What is the significance of the statement "the cancer cells will die"?
What is the significance of the statement "the cancer cells will die"?
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What is the role of carbohydrates in promoting healthy skin?
What is the role of carbohydrates in promoting healthy skin?
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Flashcards
Arachidonic Acid
Arachidonic Acid
A fatty acid chain that plays a key role in pain signaling.
Cytokines
Cytokines
Chemical messengers released by cells in response to injury.
Cyclooxygenase Pathway
Cyclooxygenase Pathway
Pathway for converting arachidonic acid into prostaglandins.
Leukotriene B4
Leukotriene B4
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NSAIDs
NSAIDs
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COX Inhibitors
COX Inhibitors
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Analgesics
Analgesics
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Phagocytic Cells
Phagocytic Cells
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Chronic Ulcer
Chronic Ulcer
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Fibroblastic Proliferation
Fibroblastic Proliferation
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Type IV Hypersensitivity Reaction
Type IV Hypersensitivity Reaction
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Perforation of Organ
Perforation of Organ
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Peritonitis
Peritonitis
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Autoimmune Conditions
Autoimmune Conditions
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Polymorphonuclear Infiltration
Polymorphonuclear Infiltration
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Hypersensitivity vs Allergy
Hypersensitivity vs Allergy
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Fibroblasts
Fibroblasts
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Granuloma
Granuloma
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Atherosclerosis
Atherosclerosis
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Macrophages
Macrophages
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T-lymphocytes
T-lymphocytes
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Chronic Inflammation
Chronic Inflammation
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Hematopoietic Stem Cells
Hematopoietic Stem Cells
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Persistent Infections
Persistent Infections
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Hypersensitivity Reactions
Hypersensitivity Reactions
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Antigens
Antigens
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Antibodies
Antibodies
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Antigen-Antibody Complex
Antigen-Antibody Complex
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Prolonged Exposure to Toxins
Prolonged Exposure to Toxins
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Scar Formation
Scar Formation
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Cell Proliferation
Cell Proliferation
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Growth Factors
Growth Factors
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Extracellular Matrix (ECM)
Extracellular Matrix (ECM)
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Tissue Repair
Tissue Repair
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Complete Regeneration
Complete Regeneration
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Angiogenesis
Angiogenesis
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Granulation Tissue
Granulation Tissue
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Collagen Formation
Collagen Formation
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Microneedling
Microneedling
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Tertiary Proteins
Tertiary Proteins
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Inflammatory Cells
Inflammatory Cells
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Study Notes
Inflammation and Tissue Repair
- Inflammation is the body's response to infection or tissue damage
- The goal is to eliminate the offending agent (e.g., microorganism)
- Inflammation also leads to tissue repair
- Mediators include phagocytic leukocytes, antibodies, and complement proteins
- Inflammation is a positive response, a crucial process for eliminating threats to the body
- Failure of inflammation can negatively impact the body
Inflammation: Sequential Events
- Recognition: The body detects noxious stimuli
- This is the initiating stimulus
Causes of Inflammation
- Infection: Different microorganisms trigger varied inflammatory responses, the resulting damage varies based on many factors.
- Tissue necrosis: cell death triggers inflammation, regardless of the cause
- Foreign bodies: elicit inflammation by causing tissue damage
- Immune reactions: Hypersensitivity reactions where the immune system damages its own tissues
Acute Inflammation
- Immediate response to injurious stimuli, blood vessels dilate
- Increased permeability of vessels allows plasma proteins and leukocytes to move into the injured area
- Leukocytes migrate to the injured site to eliminate the offending agent
- Diapedesis: The movement of leukocytes between cells
Acute Inflammation: Leukocyte Recruitment
- Increased vascular permeability allows fluid to leak into the injured area
- Increased blood flow causes swelling and redness (erythema)
- Slowed blood flow (stasis) causes leukocytes to adhere to the vessel walls (margination)
Acute Inflammation: Leukocyte Adhesion
- Selectins mediate initial rolling of leukocytes
- Integrins slow rolling, aid firm adhesion
Acute Inflammation: Chemotaxis
- Chemoattractants signal the migration of leukocytes to the site of injury
- Chemoattractants can be exogenous (external) or endogenous (internal)
Acute Inflammation: Phagocytosis
- Recognition and attachment of the particle (e.g., microorganism) to the leukocyte
- Engulfment of the particle into the leukocyte (phagocytosis)
- Killing and degradation of the particle within the leukocyte
Morphological Patterns: Serous Inflammation
- Exudation of a fluid poor in cells into spaces or body cavities (e.g., pleural, peritoneal)
- Fluid is called an effusion if within body cavities
Morphological Patterns: Fibrinous Inflammation
- Large vascular leaks, or a large stimulus triggers the formation of a fibrinous material that coagulates
- Found in lining of body cavities (e.g., meninges)
Morphological Patterns: Purulent Inflammation
- Exudate contains neutrophils and dead cells (pus)
- Pus formation often associated with bacterial infection that causes liquefactive necrosis (e.g., Streptococcus)
- Abscess: a localized collection of pus, often in body cavities
Morphological Patterns: Ulcers
- Local defects or excavations of tissue surfaces
- Often involves chronic inflammation and may be caused by infection, ischemia, or other issues
Chronic Inflammation
- Prolonged response, tissue injury and attempts to repair coexist
- May follow acute injury or begin as slow-progressing issues
- Often due to persistent infection/toxin exposure
- Involves macrophages, lymphocytes, and other cells
- Chronic inflammation leads to tissue damage, scarring (fibrosis), and potential development of diseases
Chronic Inflammation: Macrophages
- Central in chronic inflammation
- Secrete cytokines and growth factors to activate other cells and mediate inflammatory responses
Tissue Repair
- Restoration of tissue architecture and function
- Regeneration: Complete restoration of the structure
- Scar formation: Connective tissue deposition if regeneration is impossible
- Healing proceeds in stages, with inflammation often a precursor
Chronic Inflammation: Causes
- Persistent infections (e.g., Mycobacteria)
- Hypersensitivity diseases (e.g., rheumatoid arthritis)
Wound Healing Mechanisms: Acute and Chronic Injuries
- Repairing tissues has two pathways: regeneration and scarring
- Inflammation precedes the healing process
- Regeneration replaces damaged tissue with identical tissue
- Scarring replaces damaged tissue with fibrous tissue
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Description
Test your knowledge on chronic inflammation and its mediators with this quiz. It covers important concepts such as fatty acids involved in pain signaling, the role of receptors, and the function of macrophages. Dive into the mechanisms of inflammation and related conditions.