12 Questions
What is the primary cause of chronic pain according to the text?
Epigenetic changes
Why does chronic pain differ from acute pain according to the text?
Epigenetic changes occur in chronic pain
What contributes to the pathogenetic cascade that leads to chronic pain according to the text?
Activation of central sensitization pathways
How does the text describe the economic impact of chronic pain in the United States?
Costing between 560 to 635 billion dollars annually
What dramatic phenomenon related to opioid use is highlighted in the text?
High opioid addiction and overdose rates in the United States and Canada
What role do genetics play in the development of chronic pain according to the text?
Genetics contribute to transcription and transduction processes
Which ancient philosopher defined pain as an 'emotion' that occurs when the stimulus is intense and lasting?
Plato
What did experiments conducted during the nineteenth century on tactile and electrical stimulation aim to establish?
The threshold for tactile perceptions and the role of dorsal horn neurons in pain
Which theory suggested that pain could result from physical injury or psychological injury, but these two types of injuries did not influence each other?
Cartesian Dualistic Theory
What did Descartes claim about the connection between pain and the soul in his theory?
Pain's soul is in the pineal gland.
One major limitation of the Cartesian Dualistic Theory of pain mentioned in the text is its failure to account for:
Individual variations in pain experiences among chronic pain patients.
What does the text suggest as one of the reasons why people historically believed pain was a consequence of committing immoral acts?
Religious ideologies' influence on thoughts and actions
Explore the intricate mechanisms involved in the development of chronic pain, from the activation of sensitization pathways to alterations in the central nervous system. Understand how inflammation and pain, vital for healing, can sometimes lead to long-lasting negative effects.
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