Mechanisms of Chronic Pain Development

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Questions and Answers

What is the primary cause of chronic pain according to the text?

  • Activation of peripheral nociceptors
  • Altered spinal cord function
  • Epigenetic changes (correct)
  • Central nervous system brain areas

Why does chronic pain differ from acute pain according to the text?

  • Epigenetic changes occur in chronic pain (correct)
  • Different types of peripheral nociceptors are involved
  • The CNS brain areas are only affected in chronic pain
  • Chronic pain involves alterations in spinal dorsal horn neurons

What contributes to the pathogenetic cascade that leads to chronic pain according to the text?

  • Absence of genetic predisposition
  • Reduction in environmental factors
  • Decrease in opioid prescription
  • Activation of central sensitization pathways (correct)

How does the text describe the economic impact of chronic pain in the United States?

<p>Costing between 560 to 635 billion dollars annually (D)</p> Signup and view all the answers

What dramatic phenomenon related to opioid use is highlighted in the text?

<p>High opioid addiction and overdose rates in the United States and Canada (A)</p> Signup and view all the answers

What role do genetics play in the development of chronic pain according to the text?

<p>Genetics contribute to transcription and transduction processes (C)</p> Signup and view all the answers

Which ancient philosopher defined pain as an 'emotion' that occurs when the stimulus is intense and lasting?

<p>Plato (A)</p> Signup and view all the answers

What did experiments conducted during the nineteenth century on tactile and electrical stimulation aim to establish?

<p>The threshold for tactile perceptions and the role of dorsal horn neurons in pain (B)</p> Signup and view all the answers

Which theory suggested that pain could result from physical injury or psychological injury, but these two types of injuries did not influence each other?

<p>Cartesian Dualistic Theory (A)</p> Signup and view all the answers

What did Descartes claim about the connection between pain and the soul in his theory?

<p>Pain's soul is in the pineal gland. (D)</p> Signup and view all the answers

One major limitation of the Cartesian Dualistic Theory of pain mentioned in the text is its failure to account for:

<p>Individual variations in pain experiences among chronic pain patients. (D)</p> Signup and view all the answers

What does the text suggest as one of the reasons why people historically believed pain was a consequence of committing immoral acts?

<p>Religious ideologies' influence on thoughts and actions (C)</p> Signup and view all the answers

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