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12 Questions

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Mechanisms of Chronic Pain Development

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Questions and Answers

What is the primary cause of chronic pain according to the text?

Activation of peripheral nociceptors

Altered spinal cord function

Epigenetic changes (correct)

Central nervous system brain areas

Why does chronic pain differ from acute pain according to the text?

Epigenetic changes occur in chronic pain (correct)

Different types of peripheral nociceptors are involved

The CNS brain areas are only affected in chronic pain

Chronic pain involves alterations in spinal dorsal horn neurons

What contributes to the pathogenetic cascade that leads to chronic pain according to the text?

Absence of genetic predisposition

Reduction in environmental factors

Decrease in opioid prescription

Activation of central sensitization pathways (correct)

How does the text describe the economic impact of chronic pain in the United States?

Costing between 560 to 635 billion dollars annually Signup and view all the answers

What dramatic phenomenon related to opioid use is highlighted in the text?

High opioid addiction and overdose rates in the United States and Canada Signup and view all the answers

What role do genetics play in the development of chronic pain according to the text?

Genetics contribute to transcription and transduction processes Signup and view all the answers

Which ancient philosopher defined pain as an 'emotion' that occurs when the stimulus is intense and lasting?

Plato Signup and view all the answers

What did experiments conducted during the nineteenth century on tactile and electrical stimulation aim to establish?

The threshold for tactile perceptions and the role of dorsal horn neurons in pain Signup and view all the answers

Which theory suggested that pain could result from physical injury or psychological injury, but these two types of injuries did not influence each other?

Cartesian Dualistic Theory Signup and view all the answers

What did Descartes claim about the connection between pain and the soul in his theory?

Pain's soul is in the pineal gland. Signup and view all the answers

One major limitation of the Cartesian Dualistic Theory of pain mentioned in the text is its failure to account for:

Individual variations in pain experiences among chronic pain patients. Signup and view all the answers

What does the text suggest as one of the reasons why people historically believed pain was a consequence of committing immoral acts?

Religious ideologies' influence on thoughts and actions Signup and view all the answers