Chronic Bowel Disorders and Drugs Acting on the GI Tract Quiz
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Questions and Answers

What is the aim of treatment for diverticular disease?

  • To reduce the risk of complications resulting from malabsorption (correct)
  • To allay the abnormal immune response in the intestinal mucosa
  • To eliminate symptoms such as diarrhoea, bloating, and abdominal pain
  • To cure episodes of diverticulitis
  • Which dietary proteins are known to activate an abnormal immune response in the intestinal mucosa?

  • Egg albumen
  • Gluten (correct)
  • Casein
  • Whey
  • In patients with distal ileal, ileocaecal or right-sided colonic disease, what may be considered if a conventional corticosteroid is unsuitable or contra-indicated for Crohn’s disease?

  • Adalimumab
  • Methotrexate
  • Budesonide (correct)
  • Sulfasalazine
  • What causes intermittent lower abdominal pain in the absence of inflammation or infection in diverticular disease?

    <p>Formation of diverticula</p> Signup and view all the answers

    What is the primary management approach for coeliac disease?

    <p>Elimination of dietary gluten</p> Signup and view all the answers

    What is the main aim of treatment for diverticulitis?

    <p>To cure episodes of diverticular disease</p> Signup and view all the answers

    Which condition leads to malabsorption of nutrients due to an abnormal immune response in the intestinal mucosa?

    <p>Coeliac disease</p> Signup and view all the answers

    What are saclike protrusions of mucosa through the muscular colonic wall called in diverticular disease?

    <p>Diverticula</p> Signup and view all the answers

    What is the primary treatment for acute disease in Crohn’s disease?

    <p>Corticosteroids</p> Signup and view all the answers

    What could be considered for patients with Crohn’s disease when a conventional corticosteroid is unsuitable or contra-indicated?

    <p>Budesonide</p> Signup and view all the answers

    Which drug can be added to a corticosteroid or budesonide to induce remission in patients who cannot tolerate azathioprine or mercaptopurine?

    <p>Methotrexate</p> Signup and view all the answers

    What is the recommended treatment option for moderate to severely active Crohn’s disease when therapy with adalimumab or infliximab is unsuccessful, contraindicated, or not tolerated?

    <p>Vedolizumab</p> Signup and view all the answers

    Which drug can be used to manage diarrhoea associated with Crohn’s disease in those who do not have colitis?

    <p>Metronidazole</p> Signup and view all the answers

    What can improve symptoms of fistulating Crohn’s disease but complete healing occurs rarely?

    <p>Metronidazole</p> Signup and view all the answers

    Which drug is licensed for the relief of diarrhoea associated with Crohn’s disease?

    <p>Colestyramine</p> Signup and view all the answers

    What is an option for the treatment of severe, active Crohn’s disease following inadequate response to conventional therapies or in those who are intolerant of or have contraindications to conventional therapy?

    <p>Cytokine modulators</p> Signup and view all the answers

    What can be added as an add-on treatment if there are two or more inflammatory exacerbations in a 12-month period, or the corticosteroid dose cannot be reduced?

    <p>Azathioprine</p> Signup and view all the answers

    Which drug is usually given for 1 month, but no longer than 3 months because of concerns about peripheral neuropathy?

    <p>Metronidazole</p> Signup and view all the answers

    What are options for the treatment of severe, active Crohn’s disease, following inadequate response to conventional therapies or in those who are intolerant of or have contraindications to conventional therapy?

    <p>Monoclonal antibody therapies (adalimumab and infliximab)</p> Signup and view all the answers

    Which drug can be used to manage diarrhoea associated with Crohn’s disease in those who do not have colitis?

    <p>Metronidazole</p> Signup and view all the answers

    Which type of drugs are most active in the resting phase of the cell and damage DNA?

    <p>Alkylating agents</p> Signup and view all the answers

    From which organization's guidelines are the protocols MDH-SAMOC and St Luke's Cancer Alliance derived?

    <p>NCCN</p> Signup and view all the answers

    Which type of drugs are derived from certain types of plants and attack the cells during various phases of division?

    <p>Mustard gas derivatives</p> Signup and view all the answers

    Which type of therapy is known for its ability to stimulate the immune system to attack cancer cells?

    <p>Targeted therapy</p> Signup and view all the answers

    Which class of chemotherapy agents is also known as antimicrotubule agents?

    <p>Vinca alkaloids</p> Signup and view all the answers

    Which chemotherapy agent is a topoisomerase I inhibitor?

    <p>Etoposide</p> Signup and view all the answers

    Which type of targeted therapy targets the cancer’s specific genes, proteins, or the tissue environment that contributes to cancer growth and survival?

    <p>Tyrosine kinase inhibitors</p> Signup and view all the answers

    Which enzyme do Antimetabolites primarily target within the cell?

    <p>Ribonucleotide reductase</p> Signup and view all the answers

    Which hormone therapy substance acts by stopping the production of a certain hormone, blocking hormone receptors, or substituting chemically similar agents for the active hormone?

    <p>Adrenal Steroid Inhibitors</p> Signup and view all the answers

    Which drug is a folic acid antagonist used in chemotherapy?

    <p>Methotrexate</p> Signup and view all the answers

    "What is the primary aim of targeted therapy?"

    <p>-Target the cancer’s specific genes, proteins, or the tissue environment that contributes to cancer growth and survival</p> Signup and view all the answers

    "Which chemotherapy agent is an antimicrotubule agent?"

    <p>-Paclitaxel</p> Signup and view all the answers

    "Which class of chemotherapy agents does Mitomycin belong to?"

    <p>-Antitumor Antibiotics</p> Signup and view all the answers

    "Which chemotherapy agent is a topoisomerase II inhibitor?"

    <p>-Bleomycin</p> Signup and view all the answers

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