Cholestyramine Overview and Uses

Study Notes

Cholestyramine Overview

Cholestyramine, marketed as Questran, falls under the therapeutic class of antihyperlipidemics, aiming to lower cholesterol levels.
Its pharmacologic class is bile acid sequestrants, designed to bind bile acids in the intestine.

Actions and Uses

The drug binds bile acids, which are cholesterol-containing compounds, forming an insoluble complex excreted in feces.
This process results in decreased cholesterol levels within the body due to the fecal loss of bile acids.

Administration Alerts

Classified as Pregnancy Category C, indicating risks should be assessed during pregnancy.
It is crucial to mix cholestyramine thoroughly with liquids such as water or applesauce and consume immediately to prevent gastrointestinal irritation or obstruction.
Other medications should be administered at least 2 hours before or 4 hours after cholestyramine to avoid interaction.

Adverse Effects

Common side effects include constipation, bloating, gas, and nausea, which may affect patient comfort.

Contraindications

Cholestyramine is contraindicated in patients with total biliary obstruction and those with hypersensitivity to the drug.

Drug-Drug Interactions

The absorption of digoxin, penicillin, thyroid hormone, and thiazide diuretics can be impaired when taken with cholestyramine.
The drug may enhance the anticoagulant effects of certain medications, necessitating careful monitoring.

Herbal/Food Interactions

When consumed with food, cholestyramine can interfere with the absorption of various nutrients, including beta-carotene, calcium, folic acid, iron, magnesium, vitamins B12, D, E, K, and zinc.

Lab Tests

Treatment may lead to increased levels of aspartate aminotransferase, phosphorus, chloride, and alkaline phosphatase.
There can also be a decrease in serum calcium, sodium, and potassium levels, indicating possible metabolic effects.

Treatment of Overdose

No specific treatment exists for cholestyramine overdose, emphasizing the importance of adherence to prescribed dosages.

Description

This quiz explores the therapeutic and pharmacologic aspects of Cholestyramine, a drug used to lower cholesterol levels. It covers its actions, administration guidelines, and potential adverse effects. Perfect for students and healthcare professionals looking to enhance their understanding of antihyperlipidemics.