Cholesterol Transport
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Questions and Answers

Which lipoprotein is responsible for delivering dietary lipids to the liver?

  • VLDL
  • LDL
  • Chylomicrons (correct)
  • HDL

Which lipoprotein is the precursor of LDL?

  • HDL
  • Chylomicrons
  • IDL
  • VLDL (correct)

Which lipoprotein is associated with reverse cholesterol transport?

  • LDL
  • HDL (correct)
  • Chylomicrons
  • VLDL

Which lipoprotein is the most dense and smallest?

<p>LDL (C)</p> Signup and view all the answers

Which lipoprotein is responsible for mediating synthesis and secretion of chylomicrons?

<p>Apo B-48 (B)</p> Signup and view all the answers

Which lipoprotein has the highest content of cholesterol esters?

<p>LDL (D)</p> Signup and view all the answers

Which lipoprotein is associated with familial hypercholesterolemia?

<p>LDL (A)</p> Signup and view all the answers

Which lipoprotein is responsible for delivering endogenous lipids to peripheral tissues?

<p>VLDL (D)</p> Signup and view all the answers

Which lipoprotein is least dense and larger in size?

<p>Chylomicrons (B)</p> Signup and view all the answers

Which lipoprotein is required for HDL formation and activates LCAT?

<p>Apo A-1 (D)</p> Signup and view all the answers

Which lipoprotein is involved in reverse cholesterol transport?

<p>HDL (C)</p> Signup and view all the answers

Which lipoprotein carries the most direct relationship to atherosclerosis?

<p>LDL (B)</p> Signup and view all the answers

Which lipoprotein is considered vasoprotective?

<p>HDL (A)</p> Signup and view all the answers

Which lipoprotein is primarily regulated by the relative levels of circulating TG-rich lipoproteins?

<p>IDL (D)</p> Signup and view all the answers

Which lipoprotein is involved in the formation of fatty streaks in atherosclerosis?

<p>LDL (D)</p> Signup and view all the answers

Which lipoprotein is associated with Tangier disease when deficient?

<p>HDL (B)</p> Signup and view all the answers

Which lipoprotein is activated by ApoA-I and produces the majority of CE in circulating lipoproteins?

<p>HDL (A)</p> Signup and view all the answers

Which lipoprotein is involved in the transfer of cholesterol esters?

<p>IDL (B)</p> Signup and view all the answers

Which lipoprotein is synthesized by several mechanisms and contains apoA1, CII, and E?

<p>HDL (A)</p> Signup and view all the answers

Which lipoprotein is associated with an autosomal dominant disorder of the apoB gene when the missense mutation interferes with its recognition by the LDL receptor?

<p>LDL (B)</p> Signup and view all the answers

Which lipoprotein is responsible for transporting dietary triglycerides from the intestine to peripheral tissues?

<p>Chylomicrons (B)</p> Signup and view all the answers

Which lipoprotein is considered the 'bad cholesterol' because it carries cholesterol from the liver to peripheral tissues?

<p>LDL (A)</p> Signup and view all the answers

Which lipoprotein is considered the 'good cholesterol' because it carries cholesterol from peripheral tissues back to the liver for excretion?

<p>HDL (D)</p> Signup and view all the answers

Which lipoprotein is synthesized in the liver and transports endogenous triglycerides and cholesterol to peripheral tissues?

<p>VLDL (A)</p> Signup and view all the answers

Which lipoprotein is formed from the metabolism of VLDL and carries cholesterol to the liver?

<p>IDL (A)</p> Signup and view all the answers

Which lipoprotein is the largest and least dense, and primarily carries triglycerides?

<p>Chylomicrons (C)</p> Signup and view all the answers

Which lipoprotein is responsible for reverse cholesterol transport, carrying cholesterol from peripheral tissues back to the liver?

<p>HDL (A)</p> Signup and view all the answers

Which apolipoprotein is the primary structural protein of HDL and plays a crucial role in reverse cholesterol transport?

<p>ApoA-I (B)</p> Signup and view all the answers

Which essential enzyme is responsible for hydrolyzing triglycerides in lipoproteins, releasing free fatty acids for uptake by peripheral tissues?

<p>Lipoprotein lipase (C)</p> Signup and view all the answers

Which essential enzyme is responsible for esterifying free cholesterol in HDL, promoting cholesterol efflux from peripheral tissues?

<p>LCAT (D)</p> Signup and view all the answers

Flashcards

Chylomicrons

Lipoproteins that deliver dietary lipids to the liver.

VLDL

A lipoprotein that is a precursor of LDL and transports endogenous triglycerides.

HDL

Lipoprotein responsible for reverse cholesterol transport; considered 'good cholesterol'.

LDL

Lipoprotein known as 'bad cholesterol', responsible for delivering cholesterol to peripheral tissues.

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Apo B-48

Apo protein that aids in chylomicron synthesis and secretion.

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Apo A-1

Apo protein required for HDL formation and activates LCAT.

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IDL

Intermediate Density Lipoprotein involved in cholesterol transfer and regulated by TG-rich lipoproteins.

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Familial hypercholesterolemia

Condition associated with high levels of LDL due to genetic factors.

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Reverse cholesterol transport

Process by which HDL carries cholesterol from peripheral tissues back to the liver.

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Triglycerides uptake

The process by which peripheral tissues absorb free fatty acids released from triglycerides.

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Atherosclerosis

A condition caused by the accumulation of lipid deposits in arteries, often related to LDL levels.

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Tangier disease

Rare genetic disorder characterized by a deficiency of HDL.

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Lipoprotein lipase

Enzyme that hydrolyzes triglycerides in lipoproteins, releasing free fatty acids.

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LCAT

Enzyme that esterifies free cholesterol in HDL, facilitating its efflux from tissues.

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Chylomicrons size

The largest and least dense lipoproteins responsible for transporting dietary triglycerides.

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LDL density

LDL is the most dense and smaller lipoprotein compared to others.

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LDL and atherosclerosis

LDL has the most direct relationship to atherosclerosis.

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VLDL function

Transports endogenous lipids to peripheral tissues, especially triglycerides.

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HDL protective role

HDL is considered vasoprotective, protecting blood vessels from damage.

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Cholesterol esters in LDL

LDL has the highest content of cholesterol esters among lipoproteins.

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ApoB gene mutation

A mutation that leads to an autosomal dominant disorder associated with LDL.

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Endogenous lipids transport

VLDL is responsible for delivering endogenous lipids to tissues.

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Cholesterol transport from tissues

HDL carries cholesterol from tissues back to the liver for excretion.

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LDL atherogenicity

LDL's capacity to contribute to plaque formation in arteries.

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Ce in circulating lipoproteins

HDL produces the majority of cholesterol esters in the bloodstream.

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ApoA-I role

Primary structural protein of HDL that is crucial for reverse cholesterol transport.

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Fatty streaks formation

LDL contributes to the formation of fatty streaks in arteries due to plaque buildup.

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Chylomicron transport function

Chylomicrons transport dietary triglycerides from the intestine to peripheral tissues.

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Good vs Bad cholesterol

HDL is 'good' cholesterol; LDL is 'bad' cholesterol due to their functions in the body.

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