Reverse Cholesterol Transport (RCT)

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What is the main function of HDL in the process of reverse cholesterol transport?

Delivering cholesterol from the liver to peripheral cells

Carrying hydrophobic cholesteryl ester to the liver

Synthesizing bile acids in the liver

Transporting cholesterol from peripheral cells to HDL and then to the liver (correct)

What is the significance of determining the non-HDL cholesterol levels?

It indicates the level of 'good' cholesterol present

It helps in assessing the total cholesterol/HDL ratio

It provides a measure of total cholesterol content in HDL

It measures all 'bad' types of cholesterol other than HDL (correct)

Why is HDL known as the 'good' cholesterol?

It is sequestered in the core of LDL particles

It plays a role in reverse cholesterol transport (correct)

It carries cholesteryl esters to peripheral cells

It enhances atherosclerosis development

In males, what is considered the normal level for HDL?

Above 40 mg/dL Signup and view all the answers

Why is reverse cholesterol transport important for cholesterol homeostasis?

To maintain a balance between peripheral cholesterol and liver cholesterol Signup and view all the answers

What is the clinical implication of low levels of HDL in relation to atherosclerosis?

Increased risk of atherosclerosis development Signup and view all the answers

What is the primary function of LDL particles?

To provide cholesterol to the peripheral tissues Signup and view all the answers

Which apolipoprotein is found exclusively in LDL particles?

Apo-B100 Signup and view all the answers

How do high levels of LDL contribute to atherosclerosis?

By transporting cholesterol throughout the body, leading to hardening of arteries Signup and view all the answers

What is the normal level for LDL in the blood?

Less than 110 mg/dl Signup and view all the answers

How do cells with an active LDL pathway regulate their cholesterol content?

By inhibiting the de novo synthesis of cholesterol Signup and view all the answers

Which lifestyle factor is associated with high levels of LDL?

Obesity and low physical activity Signup and view all the answers

Which of the following is a primary function of HDL particles?

To transport cholesterol from peripheral tissues to the liver Signup and view all the answers

Which apolipoprotein is required for the receptor-mediated endocytosis of chylomicron remnants?

Apo E Signup and view all the answers

Which enzyme is responsible for the esterification of cholesterol taken up by HDL particles?

Lecithin:cholesterol acyltransferase (LCAT) Signup and view all the answers

Which of the following conditions is associated with impaired reverse cholesterol transport?

Familial hypercholesterolemia (FH) Signup and view all the answers

Which of the following statements about HDL composition is correct?

HDL particles contain a higher proportion of proteins than phospholipids Signup and view all the answers

Which apolipoprotein is an activator of lipoprotein lipase (LPL) and is transferred from HDL to VLDL and chylomicrons?

Apo C-II Signup and view all the answers

Reverse Cholesterol Transport (RCT)

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