18 Questions
What is the main function of HDL in the process of reverse cholesterol transport?
Transporting cholesterol from peripheral cells to HDL and then to the liver
What is the significance of determining the non-HDL cholesterol levels?
It measures all 'bad' types of cholesterol other than HDL
Why is HDL known as the 'good' cholesterol?
It plays a role in reverse cholesterol transport
In males, what is considered the normal level for HDL?
Above 40 mg/dL
Why is reverse cholesterol transport important for cholesterol homeostasis?
To maintain a balance between peripheral cholesterol and liver cholesterol
What is the clinical implication of low levels of HDL in relation to atherosclerosis?
Increased risk of atherosclerosis development
What is the primary function of LDL particles?
To provide cholesterol to the peripheral tissues
Which apolipoprotein is found exclusively in LDL particles?
Apo-B100
How do high levels of LDL contribute to atherosclerosis?
By transporting cholesterol throughout the body, leading to hardening of arteries
What is the normal level for LDL in the blood?
Less than 110 mg/dl
How do cells with an active LDL pathway regulate their cholesterol content?
By inhibiting the de novo synthesis of cholesterol
Which lifestyle factor is associated with high levels of LDL?
Obesity and low physical activity
Which of the following is a primary function of HDL particles?
To transport cholesterol from peripheral tissues to the liver
Which apolipoprotein is required for the receptor-mediated endocytosis of chylomicron remnants?
Apo E
Which enzyme is responsible for the esterification of cholesterol taken up by HDL particles?
Lecithin:cholesterol acyltransferase (LCAT)
Which of the following conditions is associated with impaired reverse cholesterol transport?
Familial hypercholesterolemia (FH)
Which of the following statements about HDL composition is correct?
HDL particles contain a higher proportion of proteins than phospholipids
Which apolipoprotein is an activator of lipoprotein lipase (LPL) and is transferred from HDL to VLDL and chylomicrons?
Apo C-II
Learn about the process of reverse cholesterol transport where cholesteryl esters are carried to the liver by HDL, aiding in cholesterol homeostasis. Understand the clinical implications of this essential mechanism.
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