Reverse Cholesterol Transport (RCT)

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Questions and Answers

What is the main function of HDL in the process of reverse cholesterol transport?

  • Delivering cholesterol from the liver to peripheral cells
  • Carrying hydrophobic cholesteryl ester to the liver
  • Synthesizing bile acids in the liver
  • Transporting cholesterol from peripheral cells to HDL and then to the liver (correct)

What is the significance of determining the non-HDL cholesterol levels?

  • It indicates the level of 'good' cholesterol present
  • It helps in assessing the total cholesterol/HDL ratio
  • It provides a measure of total cholesterol content in HDL
  • It measures all 'bad' types of cholesterol other than HDL (correct)

Why is HDL known as the 'good' cholesterol?

  • It is sequestered in the core of LDL particles
  • It plays a role in reverse cholesterol transport (correct)
  • It carries cholesteryl esters to peripheral cells
  • It enhances atherosclerosis development

In males, what is considered the normal level for HDL?

<p>Above 40 mg/dL (C)</p> Signup and view all the answers

Why is reverse cholesterol transport important for cholesterol homeostasis?

<p>To maintain a balance between peripheral cholesterol and liver cholesterol (C)</p> Signup and view all the answers

What is the clinical implication of low levels of HDL in relation to atherosclerosis?

<p>Increased risk of atherosclerosis development (A)</p> Signup and view all the answers

What is the primary function of LDL particles?

<p>To provide cholesterol to the peripheral tissues (C)</p> Signup and view all the answers

Which apolipoprotein is found exclusively in LDL particles?

<p>Apo-B100 (C)</p> Signup and view all the answers

How do high levels of LDL contribute to atherosclerosis?

<p>By transporting cholesterol throughout the body, leading to hardening of arteries (C)</p> Signup and view all the answers

What is the normal level for LDL in the blood?

<p>Less than 110 mg/dl (D)</p> Signup and view all the answers

How do cells with an active LDL pathway regulate their cholesterol content?

<p>By inhibiting the de novo synthesis of cholesterol (A)</p> Signup and view all the answers

Which lifestyle factor is associated with high levels of LDL?

<p>Obesity and low physical activity (C)</p> Signup and view all the answers

Which of the following is a primary function of HDL particles?

<p>To transport cholesterol from peripheral tissues to the liver (A)</p> Signup and view all the answers

Which apolipoprotein is required for the receptor-mediated endocytosis of chylomicron remnants?

<p>Apo E (D)</p> Signup and view all the answers

Which enzyme is responsible for the esterification of cholesterol taken up by HDL particles?

<p>Lecithin:cholesterol acyltransferase (LCAT) (A)</p> Signup and view all the answers

Which of the following conditions is associated with impaired reverse cholesterol transport?

<p>Familial hypercholesterolemia (FH) (A)</p> Signup and view all the answers

Which of the following statements about HDL composition is correct?

<p>HDL particles contain a higher proportion of proteins than phospholipids (C)</p> Signup and view all the answers

Which apolipoprotein is an activator of lipoprotein lipase (LPL) and is transferred from HDL to VLDL and chylomicrons?

<p>Apo C-II (A)</p> Signup and view all the answers

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