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Questions and Answers
What is the first stage of cholesterol biosynthesis?
What is the first stage of cholesterol biosynthesis?
- Formation of isoprenoid unit
- Synthesis of mevalonate (correct)
- Cyclization of squalene
- Formation of cholesterol
How many isoprenoid units are required to form squalene?
How many isoprenoid units are required to form squalene?
- Six isoprenoid units (correct)
- Five isoprenoid units
- Seven isoprenoid units
- Four isoprenoid units
What compound is formed after the cyclization of squalene?
What compound is formed after the cyclization of squalene?
- Mevalonate
- Cholesterol
- Isoprenoid unit
- Lanosterol (correct)
Which stage directly follows the formation of lanosterol in the cholesterol biosynthesis pathway?
Which stage directly follows the formation of lanosterol in the cholesterol biosynthesis pathway?
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What is the source of the carbon compounds used in the synthesis of mevalonate?
What is the source of the carbon compounds used in the synthesis of mevalonate?
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Study Notes
Cholesterol Biosynthesis Stages
- Cholesterol biosynthesis occurs in five distinct stages.
- The synthesis of mevalonate marks the initiation of cholesterol biosynthesis.
- Mevalonate is formed from acetyl CoA.
- The isoprenoid unit is formed from mevalonate in the second stage.
- Six isoprenoid units condense to produce squalene.
- Squalene undergoes cyclization to form lanosterol, the parent steroid.
- Cholesterol is finally formed from lanosterol in the last stage.
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