Podcast
Questions and Answers
Which type of cancer shows a cure rate of 10%-90% due to clinical trials?
Which type of cancer shows a cure rate of 10%-90% due to clinical trials?
- Colon cancer
- Acute Lymphoblastic Leukemia (correct)
- Breast cancer
- Prostate cancer
What is the primary reason for the mortality drop by ~70% in Hodgkins lymphoma?
What is the primary reason for the mortality drop by ~70% in Hodgkins lymphoma?
- Cell cycle non-specific drugs
- Screening
- Targeted therapy
- Cytotoxic chemotherapy (correct)
Which phase of the cell cycle is analogous to preparing for DNA replication?
Which phase of the cell cycle is analogous to preparing for DNA replication?
- G1 phase (correct)
- G2 phase
- M phase
- S phase
What is the main feature of cytotoxic chemotherapy?
What is the main feature of cytotoxic chemotherapy?
Which type of therapy is characterized by on-target and off-target toxicity?
Which type of therapy is characterized by on-target and off-target toxicity?
What happens when the Rb gene is active during the cell cycle?
What happens when the Rb gene is active during the cell cycle?
Which gene inactivation is associated with an increased likelihood of developing cancer?
Which gene inactivation is associated with an increased likelihood of developing cancer?
What is the function of PTEN in the cell?
What is the function of PTEN in the cell?
Which hallmark of cancer involves resistance to programmed cell death?
Which hallmark of cancer involves resistance to programmed cell death?
Which protein binds to the messenger proteins that cause apoptosis and prevents them from carrying the message?
Which protein binds to the messenger proteins that cause apoptosis and prevents them from carrying the message?
Which process involves the upregulation of the vascular endothelial growth factor (VEGF) in many cancer cells?
Which process involves the upregulation of the vascular endothelial growth factor (VEGF) in many cancer cells?
What characteristic allows cancer cells to resist apoptosis and have a limitless number of copies made of themselves?
What characteristic allows cancer cells to resist apoptosis and have a limitless number of copies made of themselves?
Which hallmark characteristic may develop without mutational changes?
Which hallmark characteristic may develop without mutational changes?
What is the process that allows cancer cells to invade surrounding tissue and later invade far away tissues?
What is the process that allows cancer cells to invade surrounding tissue and later invade far away tissues?
Which process involves the inability to repair DNA and makes cancer cells more likely to develop and keep genetic mutations?
Which process involves the inability to repair DNA and makes cancer cells more likely to develop and keep genetic mutations?
Which chemotherapeutic agent causes peripheral neuropathy that is exacerbated by cold temperatures, including cold beverages?
Which chemotherapeutic agent causes peripheral neuropathy that is exacerbated by cold temperatures, including cold beverages?
What is the chemoprotectant used to prevent ifosfamide-induced hemorrhagic cystitis?
What is the chemoprotectant used to prevent ifosfamide-induced hemorrhagic cystitis?
Which alkylating agent forms covalent bonds with DNA base pairs, leading to DNA cross-links and impairing DNA synthesis?
Which alkylating agent forms covalent bonds with DNA base pairs, leading to DNA cross-links and impairing DNA synthesis?
Which antimetabolite causes stronger inhibition of thymidylate synthetase when given with leucovorin?
Which antimetabolite causes stronger inhibition of thymidylate synthetase when given with leucovorin?
Which pyrimidine prodrug is converted to deoxyribonucleotide form and creates a highly electrophilic false substrate for thymidylate synthase?
Which pyrimidine prodrug is converted to deoxyribonucleotide form and creates a highly electrophilic false substrate for thymidylate synthase?
Which of the following is NOT a mechanism by which tumor cells can evade growth suppressors?
Which of the following is NOT a mechanism by which tumor cells can evade growth suppressors?
Which compound forms a covalent bond on one side of the DNA helix and leads to cross-linking of DNA, impairing DNA synthesis?
Which compound forms a covalent bond on one side of the DNA helix and leads to cross-linking of DNA, impairing DNA synthesis?
Which alkylating agent is historically used for treating multiple myeloma and contains a substituent that improves cellular transport?
Which alkylating agent is historically used for treating multiple myeloma and contains a substituent that improves cellular transport?
Which toxic metabolite, produced along with acrolein, is associated with neurotoxic and nephrotoxic effects in patients treated with ifosfamide?
Which toxic metabolite, produced along with acrolein, is associated with neurotoxic and nephrotoxic effects in patients treated with ifosfamide?
Which alkylating agent is more stable to intramolecular attack due to the absence of a chlorine leaving group off the vulnerable nitrogen and can be administered orally?
Which alkylating agent is more stable to intramolecular attack due to the absence of a chlorine leaving group off the vulnerable nitrogen and can be administered orally?
What is the mechanism of action of cyclophosphamide and ifosfamide?
What is the mechanism of action of cyclophosphamide and ifosfamide?
What is the primary reason for encouraging patients receiving cyclophosphamide to drink 2-3L of fluids the day of an infusion?
What is the primary reason for encouraging patients receiving cyclophosphamide to drink 2-3L of fluids the day of an infusion?
Which chemoprotectant is used to prevent ifosfamide-induced hemorrhagic cystitis?
Which chemoprotectant is used to prevent ifosfamide-induced hemorrhagic cystitis?
What is the mechanism of action of cisplatin in causing DNA damage and cell death?
What is the mechanism of action of cisplatin in causing DNA damage and cell death?
What is the primary method for preventing cisplatin-induced nephrotoxicity?
What is the primary method for preventing cisplatin-induced nephrotoxicity?
Which drug is a pro-drug of 5-fluorouracil and mimics infusional 5-FU?
Which drug is a pro-drug of 5-fluorouracil and mimics infusional 5-FU?
Which enzyme is the rate limiting step in 5-FU metabolism and deficiency of it can lead to life-threatening toxicity?
Which enzyme is the rate limiting step in 5-FU metabolism and deficiency of it can lead to life-threatening toxicity?
Which drug competes with FUTP for RNA incorporation and is used to rescue patients with dihydropyrimidine dehydrogenase (DPD) deficiency or accidental overdose?
Which drug competes with FUTP for RNA incorporation and is used to rescue patients with dihydropyrimidine dehydrogenase (DPD) deficiency or accidental overdose?
Which antimetabolite inhibits DNA polymerase & ribonucleotide reductase and is associated with profound lymphopenia and opportunistic infections?
Which antimetabolite inhibits DNA polymerase & ribonucleotide reductase and is associated with profound lymphopenia and opportunistic infections?
Which purine antimetabolite requires testing for thiopurine methyltransferase (TPMT) deficiency before initiation and may require dose reduction in case of homozygous TPMT deficiency?
Which purine antimetabolite requires testing for thiopurine methyltransferase (TPMT) deficiency before initiation and may require dose reduction in case of homozygous TPMT deficiency?
Which alkylating agent contains a substituent that improves cellular transport and has historically been used for treating multiple myeloma?
Which alkylating agent contains a substituent that improves cellular transport and has historically been used for treating multiple myeloma?
Which compound competes with 7,8-dihydrofolate for the dihydrofolate reductase (DHFR enzyme) and impairs DNA synthesis?
Which compound competes with 7,8-dihydrofolate for the dihydrofolate reductase (DHFR enzyme) and impairs DNA synthesis?
