225 Questions
What is the function of the protein kinase encoded by the Raf gene in cellular signaling?
It activates the ERK MAP kinase pathway.
What is the primary function of RecA in DNA metabolism?
It promotes the exchange of DNA strands during recombination.
Which of the following is a function of the ribosome?
Protein synthesis
Which term describes a membrane-spanning tyrosine kinase that is a receptor for extracellular ligands?
Receptor tyrosine kinase
What is the role of RNA polymerase in gene expression?
It catalyses the synthesis of RNA.
Which of the following describes a protein that recognizes stop codons and terminates translation of mRNA?
Release factor
In muscle cells, what is the contractile unit composed of interacting myosin and actin filaments called?
Sarcomere
What is the function of telomerase in cells?
Synthesis of telomeric repeat sequences at the ends of chromosomes
Which term refers to a polymer of ribonucleotides?
Ribosomal RNA (rRNA)
What is the main function of the secretory vesicle in eukaryotic cells?
Storage of nutrients
Which of the following is an early stage of evolution based on self-replicating RNA molecules?
RNA world
What is the term for a type of cancer that originates from cells of connective tissue?
Sarcoma
Which enzyme cleaves DNA at a specific sequence?
Ribonucleic acid (RNA)
The abbreviation "UTR" in 5' untranslated region (UTR) and 3' untranslated region (UTR) stands for:
Untranslated region
In plant cells, what does the vacuole primarily function to store?
Nutrients and waste products
What is the main function of the Toll-like receptor in cellular signaling?
Recognition of antigens on the surface of other cells
Which of the following describes a protein that mediates the association of actin filaments with integrins at focal adhesions?
Talin
What is the name of the complex that catalyzes the splicing of pre-mRNAs?
Spliceosome
Which molecule is a member of a group of hydrophobic hormones, including estrogen and testosterone, that are derivatives of cholesterol?
Steroid hormone
What is the process of DNA replication in which the two parental strands separate and serve as templates for the synthesis of new progeny strands called?
Replication fork
Which term describes a large complex containing clustered sites of DNA replication in eukaryotic cells?
Replication factory
What is the primary function of RecA in DNA metabolism?
It promotes the exchange of DNA strands during recombination.
Which of the following is responsible for the synthesis of RNA from a DNA template?
RNA polymerase
What is the primary function of telomerase in cells?
Synthesis of telomeric repeat sequences at the ends of chromosomes
Which molecule is a member of a group of hydrophobic hormones, including estrogen and testosterone, that are derivatives of cholesterol?
Steroid hormone
What is the main function of the secretory vesicle in eukaryotic cells?
Transportation of proteins from the Golgi apparatus to the cell surface
What is the term for a large complex containing clustered sites of DNA replication in eukaryotic cells?
Replication factory
Which term describes the ability of a microscope to distinguish objects separated by small distances?
Resolution
What is the primary function of the Ran protein in cellular processes?
Involvement in nuclear import and export
What is the primary role of the ribosome in cellular processes
Protein synthesis
In cellular signaling, what is the primary function of receptor tyrosine kinases?
Activation of the ERK MAP kinase pathway
What is the term for the synthesis of DNA from an RNA template?
Reverse transcription
Which enzyme is responsible for cleaving the 5′ end of pre-tRNAs?
RNAse P
What is the primary role of a spliceosome in gene expression?
Removal of introns from pre-mRNA
Which of the following is a regulatory molecule that blocks transcription?
Repressor
What is the primary function of the release factor in translation?
Termination of translation by recognizing stop codons
Which enzyme is responsible for degrading the RNA strand of RNA-DNA hybrid molecules?
RNAse H
In animal cell cycles, what is the regulatory point that occurs late in G1, after which a cell is committed to entering S and undergoing one cell division cycle?
Replication factory point
What is the primary role of a retrotransposon in the genome?
Movement via reverse transcription of an RNA intermediate
Which of the following describes a virus that replicates by making a DNA copy of its RNA genome by reverse transcription?
Retrovirus
Which of the following is a polymer of ribonucleotides?
Ribosomal RNA (rRNA)
What is the primary function of Smad proteins in cellular processes?
Transcriptional regulation in response to TGF-β signaling
Which of the following is a type of cell adhesion molecule that recognizes oligosaccharides exposed on the cell surface?
Selectin
What is the primary function of a scaffold protein in cellular processes?
Organization of components within signaling pathways
What is the term for the process of introducing a foreign gene into eukaryotic cells?
Transfection
What is the primary function of the Shine-Dalgarno sequence in bacterial mRNA?
Recognition and alignment of mRNA on ribosomes
What is the term for the process of synthesizing telomeric repeat sequences at the ends of chromosomes from its own RNA template?
Telomerase
Which of the following is a type of hydrophobic hormone, including estrogen and testosterone, that are derivatives of cholesterol?
Steroid hormone
In muscle cells, what is the contractile unit composed of interacting myosin and actin filaments?
Sarcomere
Which of the following is a signaling molecule synthesized from vitamin A?
Retinoic acid
What is the primary function of the Ran protein in cellular processes?
Involvement in nuclear import and export
In cellular signaling, what is the primary function of receptor tyrosine kinases?
Activation of the ERK MAP kinase pathway
What is the term for the synthesis of DNA from an RNA template?
Reverse transcription
Which enzyme is responsible for cleaving the 5′ end of pre-tRNAs?
RNAse P
What is the primary role of a spliceosome in gene expression?
Removal of introns from pre-mRNA
Which of the following is a regulatory molecule that blocks transcription?
Repressor
What is the primary function of the release factor in translation?
Termination of translation by recognizing stop codons
Which enzyme is responsible for degrading the RNA strand of RNA-DNA hybrid molecules?
RNAse H
In animal cell cycles, what is the regulatory point that occurs late in G1, after which a cell is committed to entering S and undergoing one cell division cycle?
Restriction point
What is the primary role of a retrotransposon in the genome?
Movement via reverse transcription of an RNA intermediate
Which of the following is a virus that replicates by making a DNA copy of its RNA genome by reverse transcription?
Retrovirus
What is the term for an RNA molecule that functions as an enzyme?
Ribozyme
Which of the following is a complex containing clustered sites of DNA replication in eukaryotic cells?
Replication factory
In the context of muscle contraction, what is the model that explains contraction as a result of the sliding of actin and myosin filaments relative to each other?
Sliding filament model
What is the term for a repeat of simple-sequence DNA that maintains the ends of linear chromosomes?
Satellite DNA
Which of the following is a protein translocation complex of the mitochondrial inner membrane?
Tim complex
What is the primary function of Shine-Dalgarno sequence in bacterial mRNA?
Promotion of translation of mRNA
Which of the following is a short noncoding double-strand RNA molecule that acts in the RNA interference pathway?
Short interfering RNA (siRNA)
In a cell, what is the term for the interconnected network formed by the interactions of multiple signaling pathways?
Signaling network
What is the term for a continuous network of protein strands around the circumference of epithelial cells, sealing the space between cells and forming a barrier?
Tight junction
Which of the following is a major actin-binding protein of the cell cortex?
Spectrin
What is the term for a polymer of glucose residues that is the principal storage form of carbohydrates in plants? What is the term for a polymer of glucose residues that is the principal storage form of carbohydrates in plants?
Starch
In the context of gene expression, what is the term for the process of synthesizing an RNA molecule from a DNA template?
Transcription
What is the term for a protein kinase that phosphorylates serine and threonine residues?
Serine/threonine kinase
In the context of cell cycle regulation, what is the term for the regulatory DNA sequence found in the promoters of many eukaryotic genes transcribed by RNA polymerase II?
TATA box
Which of the following is a basal transcription factor that binds directly to the TATA box in eukaryotic gene promoters?
TATA-binding protein (TBP)
What is the term for the process of reversible breakage and rejoining of DNA strands catalyzed by an enzyme?
Topoisomerase
Which of the following is an RNA molecule ranging in size from 50 to 200 bases, found in the nucleus and involved in various cellular processes?
Small nucleolar RNA (snoRNA)
What is the term for a transmembrane protein that mediates fusion of vesicle and target membranes?
SNARE
In animal cloning, what is the basic procedure where the nucleus of an adult somatic cell is transferred to an enucleated egg?
Somatic cell nuclear transfer
Which of the following is the term for the final phase of mitosis when the nuclei re-form and chromosomes decondense?
Telophase
What is the term for a repeat of simple-sequence DNA that maintains the ends of linear chromosomes?
Satellite DNA
Which of the following is a protein translocation complex of the mitochondrial outer membrane?
Toc complex
In the context of cell signaling, what is the term for a member of a family of receptors that recognize a variety of molecules associated with pathogenic bacteria and viruses?
Toll-like receptor
What is the term for a particle composed of proteins and RNA that binds to signal sequences and targets polypeptide chains to the endoplasmic reticulum?
Signal recognition particle (SRP)
In the context of protein synthesis, what is the term for a hydrophobic sequence at the amino terminus of a polypeptide chain that targets it for secretion in bacteria or incorporation into the endoplasmic reticulum in eukaryotic cells?
Signal sequence
What is the term for a DNA polymerase that uses an RNA template?
Reverse transcriptase
In the context of DNA repair, what is the term for the repair of damaged DNA by recombination with an undamaged homologous DNA molecule?
Recombinational repair
Which of the following is a large complex containing clustered sites of DNA replication in eukaryotic cells?
Replication factory
What is the term for the region of DNA synthesis where the parental strands separate, and two new daughter strands elongate?
Replication fork
In gene regulation, what is the term for a regulatory molecule that blocks transcription?
Repressor
What is the term for the use of nuclear transfer to create a cloned organism?
Somatic cell nuclear transfer
In microscopy, what is the term for the ability of a microscope to distinguish objects separated by small distances?
Resolution
Which of the following is an enzyme that cleaves DNA at a specific sequence?
Restriction endonuclease
In animal cell cycles, what is the term for the regulatory point that occurs late in G1 and commits a cell to entering S and undergoing one cell division cycle?
Restriction point
What is the term for a signaling molecule synthesized from vitamin A?
Retinoic acid
In the context of molecular biology, what is the term for a molecule related to retinoic acid?
Retinoid
What is the term for the movement of a transposable element via reverse transcription of an RNA intermediate?
Retrotransposon
Which of the following is a virus that replicates by making a DNA copy of its RNA genome by reverse transcription?
Retrovirus
What is the term for a retrotransposon that is structurally similar to a retrovirus?
Retrovirus-like element
In the context of DNA replication, what is the term for a DNA polymerase that uses an RNA template?
Reverse transcriptase
What is the term for the synthesis of DNA from an RNA template?
Reverse transcription
Which of the following is a family of small GTP-binding proteins involved in the regulation of the cytoskeleton?
Rho
What is the term for the RNA component of ribosomes?
Ribosome
In molecular biology, what is the term for an RNA enzyme?
Ribozyme
Which of the following refers to the degradation of mRNAs by short complementary double-stranded RNA molecules?
RNA interference (RNAi)
What is the term for the enzyme that recognizes stop codons and terminates translation of mRNA?
Release factor
In eukaryotic cells, what is the term for the specialized network of membranes in muscle cells that stores a high concentration of Ca2+?
Sarcoplasmic reticulum
What is the term for simple-sequence repetitive DNA with a buoyant density differing from the bulk of genomic DNA?
Satellite DNA
In the context of cell signaling, what is the term for a protein that binds to components of signaling pathways, leading to their organization in specific signaling cassettes?
Scaffold protein
What is the term for a type of cell adhesion molecule that recognizes oligosaccharides exposed on the cell surface?
Selectin
In RNA processing, what is the term for the ability of some RNAs to catalyze the removal of their own introns?
Self-splicing
What is the term for the process of DNA replication in which the two parental strands separate and serve as templates for the synthesis of new progeny strands?
Semiconservative replication
Which of the following is a hydrophobic sequence at the amino terminus of a polypeptide chain that targets it for secretion in bacteria or incorporation into the endoplasmic reticulum in eukaryotic cells?
Signal sequence
What is the term for a chain of reactions that transmits chemical signals from the cell surface to their intracellular targets?
Signaling network
Which of the following is a type of actin-binding protein that mediates the association of actin filaments with integrins at focal adhesions?
Talin
In mass spectrometry, what is the term for a method in which sequential analyses by mass spectrometry are used to determine the amino acid sequence of a peptide?
Tandem mass spectrometry
What is the term for a regulatory DNA sequence found in the promoters of many eukaryotic genes transcribed by RNA polymerase II?
TATA box
Which of the following is a basal transcription factor that binds directly to the TATA box in eukaryotic gene promoters?
TATA-binding protein (TBP)
What is the term for the reverse transcriptase that synthesizes telomeric repeat sequences at the ends of chromosomes from its own RNA template?
Telomerase
In the context of mitosis, what is the term for the final phase during which the nuclei re-form and chromosomes decondense?
Telophase
What is the term for the three-dimensional folding of a polypeptide chain that gives the protein its functional form?
Tertiary structure
Which of the following is a type of chemical bond in which atoms share a single pair of electrons?
Single bonds
What is the term for a protein that stabilizes unwound DNA by binding to single-stranded regions?
Single-stranded DNA-binding protein
In genetics, what is the term for the introduction of multiple mutations within rearranged immunoglobulin variable regions to increase antibody diversity?
Somatic hypermutation
Which of the following methods is commonly used to separate proteins by gel electrophoresis on the basis of size?
SDS-polyacrylamide gel electrophoresis (SDS-PAGE)
What is the term for the Golgi compartment within which proteins are sorted and packaged to exit the Golgi apparatus?
Trans Golgi network
Which of the following is a large membrane-enclosed sac in the cytoplasm of eukaryotic cells, often responsible for storing nutrients and waste products?
Vacuole
What is the term for a highly conserved protein that acts as a marker to target other cellular proteins for rapid degradation?
Ubiquitin
In the context of muscle contraction, what is the term for the contractile unit of muscle cells composed of interacting myosin and actin filaments?
Sarcomere
What is the term for a network of protein strands around the circumference of epithelial cells, sealing the space between cells and forming a barrier between the apical and basolateral domains?
Tight junction
In RNA processing, what is the term for a small RNA present in the nucleolus that functions in pre-rRNA processing?
Small nucleolar RNA (snoRNA)
Which of the following is a phospholipid consisting of two hydrocarbon chains bound to a polar head group containing serine?
Sphingomyelin
What is the term for a type of cell adhesion molecule that plays a role in cell-cell adhesion by recognizing homophilic interactions between cadherins?
Synaptic vesicle
In cell biology, what is the term for the movement of secreted proteins from the endoplasmic reticulum to the Golgi apparatus and then, within secretory vesicles, to the cell surface?
Secretory pathway
Which of the following is a member of a family of transcription factors activated by TGF-β receptors?
STAT protein
What is the term for a specialized microvillus of auditory hair cells?
Stereocilium
In genetics, what is the term for the process of introducing multiple mutations within rearranged immunoglobulin variable regions to increase antibody diversity?
Somatic hypermutation
Which of the following methods is used to determine the amino acid sequence of a peptide by sequential analyses in mass spectrometry?
Tandem mass spectrometry
What is the term for a protein that mediates the association of actin filaments with integrins at focal adhesions?
Talin
In RNA processing, what is the term for the sequence at the 5′ end of mRNA that correctly aligns bacterial mRNAs on ribosomes?
Shine-Dalgarno sequence
What is the term for a short noncoding double-strand RNA that acts in the RNA interference pathway to degrade specific mRNAs?
Small interfering RNA (siRNA)
In the context of cell adhesion, what is the term for a type of cell adhesion molecule that recognizes oligosaccharides exposed on the cell surface?
Selectin
What is the term for a particle composed of proteins and RNA that binds to signal sequences and targets polypeptide chains to the endoplasmic reticulum?
Signal recognition particle (SRP)
In DNA replication, what is the term for the process in which the two parental DNA strands separate and serve as templates for the synthesis of new daughter strands?
Semiconservative replication
What is the term for the ability of a microscope to distinguish objects separated by small distances?
Resolution
In DNA repair, what is the term for the repair of damaged DNA by recombination with an undamaged homologous DNA molecule?
Recombinational repair
What is the term for a regulatory molecule that blocks transcription?
Repressor
In the context of the cell cycle, what is the term for a regulatory point in animal cell cycles that occurs late in G1, after which a cell is committed to entering S and undergoing one cell division cycle?
Restriction point
What is the term for a DNA insert joined to a vector in genetic engineering?
Recombinant molecule
In molecular biology, what is the term for synthesis of DNA from an RNA template?
Reverse transcription
What is the term for a virus that replicates by making a DNA copy of its RNA genome via reverse transcription?
Retrovirus
In DNA repair, what is the term for a DNA polymerase that uses an RNA template to synthesize DNA?
Reverse transcriptase
What is the term for a transposable element that moves via reverse transcription of an RNA intermediate?
Retrotransposon
In the context of signal transduction, what is the term for a compound whose metabolism is modified as a result of a ligand-receptor interaction and functions as a signal transducer by regulating other intracellular processes?
Second messenger
What is the term for a family of small GTP-binding proteins involved in the regulation of the cytoskeleton?
Rho
In genetics, what is the term for a member of a class of repeated DNA sequences consisting of tandem arrays of thousands of copies of short sequences?
SINE (short interspersed element)
What is the term for a polymer of ribonucleotides in molecular biology?
Ribonucleic acid (RNA)
What is the term for a polymer of ribonucleotides that serves as the RNA component of ribosomes?
Ribosomal RNA (rRNA)
What is the term for a particle composed of RNA and proteins that is the site of protein synthesis?
Ribosome
In RNA processing, what is the term for an RNA enzyme?
Ribozyme
What is the term for the joining of exons in a precursor RNA molecule?
RNA splicing
What is the term for an enzyme that degrades the RNA strand of RNA-DNA hybrid molecules?
RNase H
In RNA processing, what is the term for a ribozyme that cleaves the 5′ end of pre-tRNAs?
RNase P
What is the term for an early stage of evolution based on self-replicating RNA molecules?
RNA world
In the endoplasmic reticulum, what is the term for the region that is covered with ribosomes and involved in protein metabolism?
Rough ER
What is the term for a type of chemical bond in which atoms share a single pair of electrons?
Single bonds
In genetics, what is the term for a polymer of ribonucleotides ranging in size from 50 to 200 bases?
Small nucleolar RNA (snoRNA)
What is the term for a nuclear RNA component of ribosomes?
Small nuclear ribonucleoprotein particle (snRNP)
What is the term for a member of a family of transcription factors activated by TGF-β receptors?
STAT protein
What is the term for the introduction of multiple mutations within rearranged immunoglobulin variable regions to increase antibody diversity?
Somatic hypermutation
In molecular biology, what is the term for a type of myosin other than that found in muscle cells (myosin II)?
Stereocilium
What is the term for a type of hydrophobic hormone, including estrogen and testosterone, that are derivatives of cholesterol?
Steroid hormone
In cell biology, what is the term for a bundle of actin filaments anchored at sites of cell adhesion to the extracellular matrix?
Stress fiber
What is the term for the compartment of chloroplasts that lies between the envelope and the thylakoid membrane?
Stroma
In the chloroplast, what is the term for the innermost membrane that is the site of electron transport and ATP synthesis?
Thylakoid membrane
What is the term for a membrane-enclosed sac that transports proteins from the Golgi apparatus to the cell surface?
Secretory vesicle
In cell adhesion, what is the term for a type of cell adhesion molecule that recognizes oligosaccharides exposed on the cell surface?
Selectin
What is the term for the ability of a microscope to distinguish objects separated by small distances?
Resolution
In molecular biology, what is the term for a polymer of ribonucleotides?
Transcriptome
What is the term for a hydrophobic sequence at the amino terminus of a polypeptide chain that targets it for secretion in bacteria or incorporation into the endoplasmic reticulum in eukaryotic cells?
Signal sequence
What is the term for a chain of reactions that transmits chemical signals from the cell surface to their intracellular targets?
Signal transduction
What is the term for a particle composed of proteins and RNA that binds to signal sequences and targets polypeptide chains to the endoplasmic reticulum?
Signal recognition particle (SRP)
In genetics, what is the term for a complex of an snRNA with proteins?
Small nuclear ribonucleoprotein particle (snRNP)
What is the term for a DNA sequence that can move to different positions in the genome?
Transposable element
What is the term for a dynamic behavior of actin filaments and microtubules in which the loss of subunits from one end of the filament is balanced by their addition to the other end?
Treadmilling
What is the term for the process of DNA replication in which the two parental strands separate and serve as templates for the synthesis of new progeny strands?
Semiconservative replication
In genetics, what is the term for a protein kinase that phosphorylates serine and threonine residues?
Serine/threonine kinase
What is the term for the region of DNA synthesis where the parental strands separate, and two new daughter strands elongate?
Replication factory
In genetics, what is the term for an allele that is masked by a dominant allele?
Recessive
What is the term for a regulatory point in animal cell cycles that occurs late in G1, after which a cell is committed to entering S and undergoing one cell division cycle?
Restriction point
In molecular biology, what is the term for a DNA polymerase that uses an RNA template?
Reverse transcriptase
What is the term for the repair of damaged DNA by recombination with an undamaged homologous DNA molecule?
Recombinational repair
In genetics, what is the term for a gene that acts to maintain the integrity of the genome and whose loss can lead to the Explanation: The correct answer is D. A stability gene is a gene that plays a role in maintaining the integrity of the genome, and its loss or mutation can lead to the development of cancer or genetic instability.development of cancer?
Stability gene
What is the term for a method in which the polymerase chain reaction (PCR) is used to quantitate the amount of target DNA or RNA present in a sample?
Real-time PCR
In cell biology, what is the term for a protein that stabilizes unwound DNA by binding to single-stranded regions?
Single-stranded DNA-binding protein
In cell biology, what is the term for the process of DNA replication in which the two parental strands separate, and each serves as a template for the synthesis of a new progeny strand?
Transformation
What is the term for a major actin-binding protein of the cell cortex?
Spectrin
In genetics, what is the term for a member of a family of receptors that recognize a variety of molecules associated with pathogenic bacteria and viruses?
Toll-like receptor
What is the term for a membrane-enclosed sac that transports proteins from the Golgi apparatus to the cell surface?
Secretory vesicle
In genetics, what is the term for the process of DNA replication in which the two parental strands separate, and each serves as a template for the synthesis of a new progeny strand?
Transformation
What is the term for a phospholipid consisting of two hydrocarbon chains bound to a polar head group containing serine?
Sphingomyelin
In genetics, what is the term for a short noncoding double-strand RNA that acts in the RNA interference pathway?
Short interfering RNA (siRNA)
What is the term for an RNA molecule that functions as an adaptor between amino acids and mRNA during protein synthesis?
Transfer RNA (tRNA)
In cell biology, what is the term for the innermost membrane of chloroplasts that is the site of electron transport and ATP synthesis?
Thylakoid membrane
What is the term for a member of a family of transcription factors that have an SH2 domain and are activated by tyrosine phosphorylation, which promotes their translocation from the cytoplasm to the nucleus?
STAT protein
What is the term for the separation of particles based on their rates of sedimentation?
Velocity centrifugation
What is the term for the combined use of video cameras with the light microscope to allow the visualization of small objects?
Video-enhanced microscopy
What is the major actin-bundling protein of intestinal microvilli?
Villin
Which intermediate filament protein is found in a variety of different kinds of cells?
Vimentin
Which drug inhibits microtubule polymerization?
Vinblastine
Which protein mediates the association of actin filaments with integrins at focal adhesions?
Vinculin
What is the term for a vitamin that regulates calcium metabolism and bone growth by stimulating the activity of a member of the nuclear receptor superfamily?
Vitamin D3
Which type of ion channel opens in response to changes in electric potential?
Voltage-gated channel
What is the term for a protein that stimulates actin filament branching?
WASP
What is the term for a method in which yeast genetics is used to identify proteins that interact with one another?
Yeast two-hybrid system
What is the term for the dosage compensation mechanism in which most of the genes on one X chromosome are inactivated in female cells?
X chromosome inactivation
What is the method in which the diffraction pattern of X-rays is used to determine the arrangement of individual atoms within a molecule?
X-ray crystallography
What is the term for an African clawed frog used as a model system for developmental biology?
Xenopus laevis
What is the simplest unicellular eukaryotes and are important models for studies of eukaryotic cells?
Yeast
What is a vector that can replicate as a chromosome in yeast cells and can accommodate very large DNA inserts (hundreds of kb)?
Yeast artificial chromosome (YAC)
What is the term for the secreted signaling molecule that stimulates a pathway regulating cell fate during embryonic development?
Wnt
What is the term for a dosage compensation mechanism in which most of the genes on one X chromosome are inactivated in female cells?
X chromosome inactivation
What is the method in which yeast genetics is used to identify proteins that interact with one another?
Yeast two-hybrid system
What is a species of small fish used for genetic studies of vertebrate development?
Zebrafish
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