Adrenal Gland 2

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Questions and Answers

What enzyme converts L-tyrosine to L-DOPA inside chromaffin cells?

  • COMT
  • Tyrosine hydroxylase (correct)
  • Dopamine beta-hydroxylase
  • MAO

Which enzyme is responsible for converting dopamine to norepinephrine within chromaffin granules?

  • COMT
  • Dopamine beta-hydroxylase (correct)
  • MAO
  • Tyrosine hydroxylase

Where is epinephrine stored before release by pre-ganglionic sympathetic neurons?

  • Endoplasmic reticulum
  • Cytosol (correct)
  • Nucleus
  • Mitochondria

Which enzyme is primarily responsible for metabolism of epinephrine and norepinephrine in the liver and kidney?

<p>COMT (C)</p> Signup and view all the answers

What is the main effect of stimulating alpha receptors in arterioles of most visceral organs?

<p>Contraction of arteriolar smooth muscle (D)</p> Signup and view all the answers

Which adrenergic receptor type is responsible for increasing glycogenolysis and gluconeogenesis in the liver?

<p>Beta1 (C)</p> Signup and view all the answers

What is the main metabolic effect of cortisol on protein metabolism?

<p>Decreases RNA and protein synthesis (D)</p> Signup and view all the answers

Which hormone is primarily responsible for increasing the sensitivity of vascular smooth muscle to vasoconstrictors?

<p>Cortisol (B)</p> Signup and view all the answers

In response to stress, cortisol acts to shift metabolism from glucose to:

<p>Fat utilization (A)</p> Signup and view all the answers

What is the primary effect of cortisol on bone health?

<p>Decreases bone formation (B)</p> Signup and view all the answers

Which of the following is a common consequence of elevated cortisol levels?

<p>Development of Diabetes Mellitus (C)</p> Signup and view all the answers

What is the primary function of cortisol in relation to glucose metabolism?

<p>Stimulate gluconeogenesis in the liver (C)</p> Signup and view all the answers

How does cortisol affect fat metabolism in adipose tissue?

<p>Enhances oxidation of fatty acids in cells (B)</p> Signup and view all the answers

Which type of receptors does cortisol bind to in the cytosol before migrating to the nucleus?

<p>Glucocorticoid receptors (C)</p> Signup and view all the answers

What is the primary enzyme responsible for converting L-tyrosine to L-DOPA inside chromaffin cells?

<p>Tyrosine hydroxylase (D)</p> Signup and view all the answers

Which enzyme is primarily involved in the metabolism of epinephrine and norepinephrine in the liver and kidney?

<p>Catechol-O-methyltransferases (D)</p> Signup and view all the answers

What is the major type of adrenergic receptor that dopamine binds to?

<p>Beta1 (B)</p> Signup and view all the answers

Which neurotransmitter is converted to epinephrine in the cytosol?

<p>Norepinephrine (D)</p> Signup and view all the answers

In the fight or flight response, which receptor type causes vasodilation of skeletal muscle and liver arterioles?

<p>Beta2 (A)</p> Signup and view all the answers

What effect does the stimulation of alpha receptors have on arterioles of most visceral organs?

<p>Contraction of arteriolar smooth muscle (C)</p> Signup and view all the answers

What is the primary function of mineralocorticoids like aldosterone?

<p>Regulate electrolyte and water balance (A)</p> Signup and view all the answers

Which hormone is responsible for shifting metabolism from glucose to fat utilization?

<p>Cortisol (D)</p> Signup and view all the answers

What is the primary effect of cortisol on bone health?

<p>Decreases bone formation (A)</p> Signup and view all the answers

Which of the following is NOT a main effect of cortisol on carbohydrate metabolism?

<p>Stimulates glycogen synthesis (B)</p> Signup and view all the answers

In response to stress, which hormone acts to prevent connective tissue synthesis and inflammation?

<p>Cortisol (A)</p> Signup and view all the answers

What is the significance of adrenal androgens in most animals?

<p>Contribute significantly to libido and secondary sexual characteristics (A)</p> Signup and view all the answers

Which of the following best describes the role of catecholamines like epinephrine during short-term stress (fight or flight response)?

<p>Increase blood flow to skeletal muscles and elevate blood glucose levels (A)</p> Signup and view all the answers

Which hormone is responsible for stabilizing lysosomal membranes and decreasing release of proteolytic enzymes by damaged cells?

<p>Cortisol (D)</p> Signup and view all the answers

What enzyme is primarily responsible for converting DHEA into testosterone in the testes or ovaries?

<p>17-beta hydroxysteroid dehydrogenase (B)</p> Signup and view all the answers

Which of the following is NOT a primary effect of cortisol on protein metabolism?

<p>Stimulation of muscle fiber synthesis (C)</p> Signup and view all the answers

What enzyme is responsible for converting dopamine to norepinephrine within chromaffin granules?

<p>Dopamine beta-hydroxylase (C)</p> Signup and view all the answers

Where are epinephrine stored before release by pre-ganglionic sympathetic neurons?

<p>Vesicles (D)</p> Signup and view all the answers

Which adrenergic receptor type causes vasodilation of skeletal muscle and liver arterioles?

<p>Beta-2 (B)</p> Signup and view all the answers

What is the primary function of mineralocorticoids like aldosterone?

<p>Regulate water and electrolyte balance (D)</p> Signup and view all the answers

Which enzyme is primarily responsible for the metabolism of epinephrine and norepinephrine in the liver and kidney?

<p>Catechol-O-methyltransferase (COMT) (C)</p> Signup and view all the answers

Which hormone is responsible for stabilizing lysosomal membranes and decreasing the release of proteolytic enzymes by damaged cells?

<p>Cortisol (B)</p> Signup and view all the answers

What stimulates the secretion of catecholamines like epinephrine and norepinephrine during short-term stress?

<p>Pituitary adenylate cyclase-activating polypeptide (PACAP) (B)</p> Signup and view all the answers

Where does free cortisol bind before migrating to the nucleus to stimulate or inhibit gene expression?

<p>Cytosol (B)</p> Signup and view all the answers

Which hormone is primarily responsible for mobilizing fatty acids from adipose tissue?

<p>Epinephrine (C)</p> Signup and view all the answers

What is the main effect of cortisol on glucose metabolism in the liver?

<p>Antagonism of insulin's inhibitory effect on gluconeogenesis (D)</p> Signup and view all the answers

In adrenal insufficiency (Addisons Disease), what are the characteristic symptoms of a hypoactive adrenal cortex?

<p>Decreased appetite and weight loss (D)</p> Signup and view all the answers

Which of the following hormones contributes to the increase in visceral (abdominal) fat deposition known as 'potbelly'?

<p>Corticosterone (B)</p> Signup and view all the answers

What is the primary function of corticosteroid-binding globulin (CBG) transcortin in cortisol transport?

<p>Enhancing cortisol's binding to cell receptors (D)</p> Signup and view all the answers

Which enzyme is responsible for converting AA from muscle into substrates for gluconeogenesis during increased cortisol release?

<p>Phosphoenolpyruvate carboxykinase (C)</p> Signup and view all the answers

What biological response is cortisol primarily involved in maintaining when reacting to external or internal stimuli?

<p>Homeostasis (A)</p> Signup and view all the answers

Which enzyme is responsible for the conversion of L-tyrosine to L-DOPA inside chromaffin cells?

<p>Tyrosine hydroxylase (C)</p> Signup and view all the answers

When NE binds to adrenoceptors on target tissues, what is the main role of these GPCR receptors in the context of the text?

<p>Increasing energy availability (A)</p> Signup and view all the answers

Which enzyme is primarily responsible for the conversion of NE to Epinephrine in the cytosol?

<p>Dopamine beta-hydroxylase (B)</p> Signup and view all the answers

In the context of liver and kidney metabolism, which system primarily degrades NE and Epinephrine?

<p>Methylation via catechol-O-methyltransferases and monoamine oxidase system (D)</p> Signup and view all the answers

Which adrenergic receptors, when stimulated, cause vasodilation of skeletal muscle and liver arterioles?

<p>Beta (β) receptors (B)</p> Signup and view all the answers

What is the main effect of the stimulation of alpha receptors in the arterioles of most visceral organs?

<p>Contraction of arteriolar smooth muscle (A)</p> Signup and view all the answers

What is the main effect of cortisol on protein metabolism?

<p>Decreases RNA and protein synthesis (D)</p> Signup and view all the answers

In response to stress, which hormone acts to prevent connective tissue synthesis and inflammation?

<p>Epinephrine (C)</p> Signup and view all the answers

What is the primary function of corticosteroid-binding globulin (CBG) transcortin in cortisol transport?

<p>Binds to cortisol to increase its solubility (A)</p> Signup and view all the answers

Which enzyme is primarily involved in the metabolism of epinephrine and norepinephrine in the liver and kidney?

<p>Catechol-O-methyltransferase (COMT) (D)</p> Signup and view all the answers

Which hormone is responsible for increasing the sensitivity of vascular smooth muscle to vasoconstrictors?

<p>Cortisol (B)</p> Signup and view all the answers

What does cortisol primarily do to glucose metabolism in the liver?

<p>Promotes glucose breakdown (B)</p> Signup and view all the answers

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