Adrenal Gland 2
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Questions and Answers

What enzyme converts L-tyrosine to L-DOPA inside chromaffin cells?

  • COMT
  • Tyrosine hydroxylase (correct)
  • Dopamine beta-hydroxylase
  • MAO
  • Which enzyme is responsible for converting dopamine to norepinephrine within chromaffin granules?

  • COMT
  • Dopamine beta-hydroxylase (correct)
  • MAO
  • Tyrosine hydroxylase
  • Where is epinephrine stored before release by pre-ganglionic sympathetic neurons?

  • Endoplasmic reticulum
  • Cytosol (correct)
  • Nucleus
  • Mitochondria
  • Which enzyme is primarily responsible for metabolism of epinephrine and norepinephrine in the liver and kidney?

    <p>COMT</p> Signup and view all the answers

    What is the main effect of stimulating alpha receptors in arterioles of most visceral organs?

    <p>Contraction of arteriolar smooth muscle</p> Signup and view all the answers

    Which adrenergic receptor type is responsible for increasing glycogenolysis and gluconeogenesis in the liver?

    <p>Beta1</p> Signup and view all the answers

    What is the main metabolic effect of cortisol on protein metabolism?

    <p>Decreases RNA and protein synthesis</p> Signup and view all the answers

    Which hormone is primarily responsible for increasing the sensitivity of vascular smooth muscle to vasoconstrictors?

    <p>Cortisol</p> Signup and view all the answers

    In response to stress, cortisol acts to shift metabolism from glucose to:

    <p>Fat utilization</p> Signup and view all the answers

    What is the primary effect of cortisol on bone health?

    <p>Decreases bone formation</p> Signup and view all the answers

    Which of the following is a common consequence of elevated cortisol levels?

    <p>Development of Diabetes Mellitus</p> Signup and view all the answers

    What is the primary function of cortisol in relation to glucose metabolism?

    <p>Stimulate gluconeogenesis in the liver</p> Signup and view all the answers

    How does cortisol affect fat metabolism in adipose tissue?

    <p>Enhances oxidation of fatty acids in cells</p> Signup and view all the answers

    Which type of receptors does cortisol bind to in the cytosol before migrating to the nucleus?

    <p>Glucocorticoid receptors</p> Signup and view all the answers

    What is the primary enzyme responsible for converting L-tyrosine to L-DOPA inside chromaffin cells?

    <p>Tyrosine hydroxylase</p> Signup and view all the answers

    Which enzyme is primarily involved in the metabolism of epinephrine and norepinephrine in the liver and kidney?

    <p>Catechol-O-methyltransferases</p> Signup and view all the answers

    What is the major type of adrenergic receptor that dopamine binds to?

    <p>Beta1</p> Signup and view all the answers

    Which neurotransmitter is converted to epinephrine in the cytosol?

    <p>Norepinephrine</p> Signup and view all the answers

    In the fight or flight response, which receptor type causes vasodilation of skeletal muscle and liver arterioles?

    <p>Beta2</p> Signup and view all the answers

    What effect does the stimulation of alpha receptors have on arterioles of most visceral organs?

    <p>Contraction of arteriolar smooth muscle</p> Signup and view all the answers

    What is the primary function of mineralocorticoids like aldosterone?

    <p>Regulate electrolyte and water balance</p> Signup and view all the answers

    Which hormone is responsible for shifting metabolism from glucose to fat utilization?

    <p>Cortisol</p> Signup and view all the answers

    What is the primary effect of cortisol on bone health?

    <p>Decreases bone formation</p> Signup and view all the answers

    Which of the following is NOT a main effect of cortisol on carbohydrate metabolism?

    <p>Stimulates glycogen synthesis</p> Signup and view all the answers

    In response to stress, which hormone acts to prevent connective tissue synthesis and inflammation?

    <p>Cortisol</p> Signup and view all the answers

    What is the significance of adrenal androgens in most animals?

    <p>Contribute significantly to libido and secondary sexual characteristics</p> Signup and view all the answers

    Which of the following best describes the role of catecholamines like epinephrine during short-term stress (fight or flight response)?

    <p>Increase blood flow to skeletal muscles and elevate blood glucose levels</p> Signup and view all the answers

    Which hormone is responsible for stabilizing lysosomal membranes and decreasing release of proteolytic enzymes by damaged cells?

    <p>Cortisol</p> Signup and view all the answers

    What enzyme is primarily responsible for converting DHEA into testosterone in the testes or ovaries?

    <p>17-beta hydroxysteroid dehydrogenase</p> Signup and view all the answers

    Which of the following is NOT a primary effect of cortisol on protein metabolism?

    <p>Stimulation of muscle fiber synthesis</p> Signup and view all the answers

    What enzyme is responsible for converting dopamine to norepinephrine within chromaffin granules?

    <p>Dopamine beta-hydroxylase</p> Signup and view all the answers

    Where are epinephrine stored before release by pre-ganglionic sympathetic neurons?

    <p>Vesicles</p> Signup and view all the answers

    Which adrenergic receptor type causes vasodilation of skeletal muscle and liver arterioles?

    <p>Beta-2</p> Signup and view all the answers

    What is the primary function of mineralocorticoids like aldosterone?

    <p>Regulate water and electrolyte balance</p> Signup and view all the answers

    Which enzyme is primarily responsible for the metabolism of epinephrine and norepinephrine in the liver and kidney?

    <p>Catechol-O-methyltransferase (COMT)</p> Signup and view all the answers

    Which hormone is responsible for stabilizing lysosomal membranes and decreasing the release of proteolytic enzymes by damaged cells?

    <p>Cortisol</p> Signup and view all the answers

    What stimulates the secretion of catecholamines like epinephrine and norepinephrine during short-term stress?

    <p>Pituitary adenylate cyclase-activating polypeptide (PACAP)</p> Signup and view all the answers

    Where does free cortisol bind before migrating to the nucleus to stimulate or inhibit gene expression?

    <p>Cytosol</p> Signup and view all the answers

    Which hormone is primarily responsible for mobilizing fatty acids from adipose tissue?

    <p>Epinephrine</p> Signup and view all the answers

    What is the main effect of cortisol on glucose metabolism in the liver?

    <p>Antagonism of insulin's inhibitory effect on gluconeogenesis</p> Signup and view all the answers

    In adrenal insufficiency (Addisons Disease), what are the characteristic symptoms of a hypoactive adrenal cortex?

    <p>Decreased appetite and weight loss</p> Signup and view all the answers

    Which of the following hormones contributes to the increase in visceral (abdominal) fat deposition known as 'potbelly'?

    <p>Corticosterone</p> Signup and view all the answers

    What is the primary function of corticosteroid-binding globulin (CBG) transcortin in cortisol transport?

    <p>Enhancing cortisol's binding to cell receptors</p> Signup and view all the answers

    Which enzyme is responsible for converting AA from muscle into substrates for gluconeogenesis during increased cortisol release?

    <p>Phosphoenolpyruvate carboxykinase</p> Signup and view all the answers

    What biological response is cortisol primarily involved in maintaining when reacting to external or internal stimuli?

    <p>Homeostasis</p> Signup and view all the answers

    Which enzyme is responsible for the conversion of L-tyrosine to L-DOPA inside chromaffin cells?

    <p>Tyrosine hydroxylase</p> Signup and view all the answers

    When NE binds to adrenoceptors on target tissues, what is the main role of these GPCR receptors in the context of the text?

    <p>Increasing energy availability</p> Signup and view all the answers

    Which enzyme is primarily responsible for the conversion of NE to Epinephrine in the cytosol?

    <p>Dopamine beta-hydroxylase</p> Signup and view all the answers

    In the context of liver and kidney metabolism, which system primarily degrades NE and Epinephrine?

    <p>Methylation via catechol-O-methyltransferases and monoamine oxidase system</p> Signup and view all the answers

    Which adrenergic receptors, when stimulated, cause vasodilation of skeletal muscle and liver arterioles?

    <p>Beta (β) receptors</p> Signup and view all the answers

    What is the main effect of the stimulation of alpha receptors in the arterioles of most visceral organs?

    <p>Contraction of arteriolar smooth muscle</p> Signup and view all the answers

    What is the main effect of cortisol on protein metabolism?

    <p>Decreases RNA and protein synthesis</p> Signup and view all the answers

    In response to stress, which hormone acts to prevent connective tissue synthesis and inflammation?

    <p>Epinephrine</p> Signup and view all the answers

    What is the primary function of corticosteroid-binding globulin (CBG) transcortin in cortisol transport?

    <p>Binds to cortisol to increase its solubility</p> Signup and view all the answers

    Which enzyme is primarily involved in the metabolism of epinephrine and norepinephrine in the liver and kidney?

    <p>Catechol-O-methyltransferase (COMT)</p> Signup and view all the answers

    Which hormone is responsible for increasing the sensitivity of vascular smooth muscle to vasoconstrictors?

    <p>Cortisol</p> Signup and view all the answers

    What does cortisol primarily do to glucose metabolism in the liver?

    <p>Promotes glucose breakdown</p> Signup and view all the answers

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