Cellular Adaptation to Environmental Stress
44 Questions
2 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the main role of cellular and systemic stress responses in mammalian cells?

  • To increase cell death
  • To promote rapid cell division
  • To disregard environmental changes
  • To maintain organismal homeostasis (correct)
  • Mammalian cells cannot respond to environmental stresses.

    False (B)

    What occurs during the time lag between stress and morphological changes in cells?

    There is a delay where cellular responses may not immediately reflect observed changes.

    If the microenvironment fluctuations are too large or prolonged, mammalian cells will experience __________.

    <p>senescence</p> Signup and view all the answers

    Match the following terms with their definitions:

    <p>Senescence = State of permanent cell cycle arrest Regulated Cell Death (RCD) = Controlled process leading to cell death under stress Homeostasis = Maintenance of stable internal conditions Stress Response = Biochemical reaction of cells to external stimuli</p> Signup and view all the answers

    What kind of signals are involved in cellular adaptation to stress?

    <p>Danger signals (A)</p> Signup and view all the answers

    Cellular aging is influenced solely by genetic factors.

    <p>False (B)</p> Signup and view all the answers

    What type of plants are known for their unique mechanisms that allow them to survive extreme drought conditions?

    <p>Resurrection plants</p> Signup and view all the answers

    The relative water content (RWC) is an important measure related to __________ in plants.

    <p>drought response</p> Signup and view all the answers

    Match the type of plants with their characteristics:

    <p>Resurrection plants = Survive extreme drought Non-resurrection plants = Regular water requirement Boea hygrometrica = Type of resurrection plant Arabidopsis thaliana = Type of non-resurrection plant</p> Signup and view all the answers

    What is the role of cell-extrinsic mechanisms in cellular responses?

    <p>They help maintain organism homeostasis. (B)</p> Signup and view all the answers

    Abnormalities in cellular processes can lead to aging.

    <p>True (A)</p> Signup and view all the answers

    What is the primary consequence of mitochondrial damage?

    <p>Decreased ATP production (D)</p> Signup and view all the answers

    Ischemia can result from a decrease in the ability of blood to transport oxygen.

    <p>True (A)</p> Signup and view all the answers

    What is the significance of paracrine or endocrine mediators in cellular stress response?

    <p>They regulate cellular homeostasis.</p> Signup and view all the answers

    Name two physical agents that can damage cells.

    <p>Mechanical trauma, radiation</p> Signup and view all the answers

    ______ and ______ are examples of chemical agents that can harm cells.

    <p>Cyanide, asbestos</p> Signup and view all the answers

    Match the following stimuli with their categories:

    <p>Cyanide = Chemical agent Mechanical trauma = Physical agent Hypoxia = Oxygen deficiency Autoimmune disease = Immunological reaction</p> Signup and view all the answers

    Which of the following is NOT a cause of cell injury?

    <p>Proper hydration (B)</p> Signup and view all the answers

    When energy-rich phosphate in the form of ATP decreases, one major consequence is _______ cell swelling.

    <p>increased</p> Signup and view all the answers

    Autoimmune diseases are caused by the body's immune reaction to external agents.

    <p>False (B)</p> Signup and view all the answers

    Which type of cellular adaptation results in an increase in cell size?

    <p>Hypertrophy (D)</p> Signup and view all the answers

    Homeostasis refers to a state where cells function suboptimally.

    <p>False (B)</p> Signup and view all the answers

    What is the term used when a normal cell undergoes transformation into a different cell type?

    <p>Metaplasia</p> Signup and view all the answers

    The process where cells die due to ischemia is called __________.

    <p>necrosis</p> Signup and view all the answers

    Match the types of cell injury with their outcomes:

    <p>Reversible injury = Function can be restored Irreversible injury = Cell death occurs Stress = Potential for cellular adaptation Cellular adaptation = Changes in structure or function</p> Signup and view all the answers

    Which of the following mechanisms is NOT a cause of cell injury?

    <p>Increased nutrient supply (D)</p> Signup and view all the answers

    Dysplasia refers to a normal growth pattern of cells.

    <p>False (B)</p> Signup and view all the answers

    What happens to enzymes after cell death?

    <p>They leak out of the cell.</p> Signup and view all the answers

    What happens to ATP levels when calcium homeostasis fails?

    <p>ATP levels decrease (D)</p> Signup and view all the answers

    Radical oxygen species (ROS) are harmful only to DNA.

    <p>False (B)</p> Signup and view all the answers

    Name one enzyme that acts as an antioxidant.

    <p>Superoxide dismutase (SOD)</p> Signup and view all the answers

    The primary defect caused by decreased ATP levels during cell injury is the opening of the ________ in mitochondria.

    <p>mPTP</p> Signup and view all the answers

    Match the following enzymes with their functions:

    <p>SOD = Converts superoxide to hydrogen peroxide Catalase = Decomposes hydrogen peroxide Glutathione peroxidase = Reduces lipid peroxides Phospholipases = Affects membrane integrity</p> Signup and view all the answers

    Which of the following stimuli can cause cell injury?

    <p>Low oxygen levels (A)</p> Signup and view all the answers

    Endonucleases are involved in the degradation of membrane proteins.

    <p>False (B)</p> Signup and view all the answers

    What is the consequence of an increased influx of Ca²⁺ during cell injury?

    <p>Activation of destructive enzymes leading to cell damage</p> Signup and view all the answers

    What is a characteristic response of resurrection plants to water loss?

    <p>Leaf shrinking and curling (D)</p> Signup and view all the answers

    Non-resurrection plants exhibit signs of damage and metabolic disruption when water is lost.

    <p>True (A)</p> Signup and view all the answers

    What process is induced at the cellular level due to drought in resurrection plants?

    <p>Cell shrinkage and cell wall folding</p> Signup and view all the answers

    Resurrection plants activate protective mechanisms and repair processes through __________ signaling.

    <p>apoplastic</p> Signup and view all the answers

    What happens to the mitochondria of resurrection plants during drought?

    <p>They undergo alternative oxidase upregulation (B)</p> Signup and view all the answers

    Resurrection plants do not activate any protective mechanisms during water loss.

    <p>False (B)</p> Signup and view all the answers

    What is indicated by the term 'RWC' in relation to water loss in plants?

    <p>Relative Water Content</p> Signup and view all the answers

    Flashcards

    Cellular Adaptation

    A cell's ability to change its structure or function in response to external stimuli, enabling it to survive and thrive in different environments. These changes are reversible, meaning the cell can return to its original state once the stimulus is removed.

    Hypertrophy

    An increase in the size of a cell due to an increase in the number of cellular components, particularly proteins and organelles.

    Hyperplasia

    An increase in the number of cells within a tissue or organ due to increased cell division.

    Atrophy

    A decrease in the size and number of cells within a tissue or organ.

    Signup and view all the flashcards

    Metaplasia

    The transformation of one mature cell type to another mature cell type. This is a protective mechanism to better withstand environmental stress.

    Signup and view all the flashcards

    Reversible Cell Injury

    A type of cell injury that is reversible, meaning the cell can return to its normal state if the damaging stimulus is removed.

    Signup and view all the flashcards

    Irreversible Cell Injury

    A type of cell injury that is irreversible, leading to cell death.

    Signup and view all the flashcards

    Point of No Return

    The point where an injury transitions from reversible to irreversible, causing the cell to die.

    Signup and view all the flashcards

    Apoptosis

    A process of programmed cell death that involves a series of biochemical events leading to the dismantling of the cell and the removal of its components by phagocytosis. This process is characterized by specific morphological and biochemical features.

    Signup and view all the flashcards

    Necrosis

    A process of uncontrolled cell death caused by injury or damage to the cell that results in swelling, rupture, and inflammation. The release of intracellular contents can trigger an inflammatory response.

    Signup and view all the flashcards

    Hypoxia

    A type of cell injury caused by a lack of oxygen, which leads to a decrease in ATP production and can ultimately lead to cell death. The loss of oxygen can be due to ischemia, respiratory failure, or decreased blood oxygen-carrying capacity.

    Signup and view all the flashcards

    Mitochondria

    A crucial organelle in cells responsible for the production of ATP, the main energy currency used by cells to perform various functions.

    Signup and view all the flashcards

    Reactive Oxygen Species (ROS)

    A group of highly reactive molecules that can damage cells and contribute to various diseases. They are produced as a byproduct of normal metabolism and increased during cell stress or injury.

    Signup and view all the flashcards

    Oxidative phosphorylation

    A pathway for ATP production that requires oxygen. It is the main energy-producing pathway in most mammalian cells.

    Signup and view all the flashcards

    Glycolytic pathway

    A pathway for ATP production that does not require oxygen. It can produce ATP in anaerobic conditions, using glucose from the body fluids or glycogen breakdown.

    Signup and view all the flashcards

    Homeostasis

    The process of maintaining a stable internal environment within cells and organisms. It involves various mechanisms that regulate factors like temperature, pH, and ion concentrations.

    Signup and view all the flashcards

    Glycolytic Capacity and ATP Depletion

    Cells with high glycolytic capacity, like liver cells, can better cope with ATP depletion during oxidative stress due to injury. This is because they can rely on glycolysis to generate ATP even when oxidative phosphorylation is compromised.

    Signup and view all the flashcards

    Calcium Homeostasis Disruption

    Calcium homeostasis is maintained through storage in organelles like the mitochondria and ER. When disrupted, calcium levels rise, leading to various detrimental effects.

    Signup and view all the flashcards

    Cell Injury Stimuli

    Reduced oxygen supply to cells (ischemia) and toxins can disrupt normal cellular function and lead to injury.

    Signup and view all the flashcards

    mPTP and ATP Depletion

    Elevated calcium levels open the mitochondrial permeability transition pore (mPTP), causing disruption of ATP production.

    Signup and view all the flashcards

    Calcium-Activated Enzymes and Damage

    Increased calcium leads to activation of various enzymes, like phospholipases, proteases, and endonucleases, causing damage to cell membranes, proteins, and DNA.

    Signup and view all the flashcards

    Reactive Oxygen Species (ROS) and Cell Injury

    Reactive oxygen species (ROS) are produced in various cellular compartments like the ER, mitochondria, and cytosol. They cause damage to lipids, proteins, and DNA, contributing to cell injury.

    Signup and view all the flashcards

    Antioxidant Enzymes and Protection

    Antioxidant enzymes like superoxide dismutase (SOD), catalase, and glutathione peroxidase (GSH) protect cells from oxidative damage caused by ROS.

    Signup and view all the flashcards

    Cell Injury and Necrosis

    Persistent injury leads to biochemical and morphological changes in cells, ultimately resulting in cell death through necrosis.

    Signup and view all the flashcards

    Time Lag in Cell Response to Stress

    Stress and its harmful effects on cells are initially detected at a biochemical and molecular level. There's a delay between the onset of stress and visible changes in cell injury or death, known as a "time lag". This delay varies depending on the cell's sensitivity and the observation method used.

    Signup and view all the flashcards

    Cellular Homeostasis

    Cells continuously adapt to maintain a balanced internal environment, reacting to changes within and outside the cell. This process, called cellular homeostasis, involves mechanisms for repair and restoration.

    Signup and view all the flashcards

    Cell's Decision Point: Survive or Die

    If the external environment becomes too extreme for too long, cells face a critical point where they decide whether to keep functioning or activate protective mechanisms.

    Signup and view all the flashcards

    Cell Senescence and Regulated Cell Death (RCD)

    When cells can't maintain normal function, they activate mechanisms like cell senescence (permanent aging) or programmed cell death (RCD). These mechanisms help regulate the overall health of the organism.

    Signup and view all the flashcards

    Cellular Adaptation to Stress

    Cells adjust their behavior and functions in response to stressful conditions. This adaptation is crucial for survival in constantly changing environments.

    Signup and view all the flashcards

    Cellular Aging

    The process of cellular aging, influenced by both genetic and environmental factors, leading to cell abnormalities and characteristic aging changes.

    Signup and view all the flashcards

    Cell-Extrinsic Mechanisms in Homeostasis

    Cellular responses to stress are controlled by cell-extrinsic mechanisms that maintain homeostasis. These mechanisms operate locally and systemically, using "danger signals" to regulate cellular responses.

    Signup and view all the flashcards

    Danger Signals

    Signals that alert neighboring cells or the entire organism about potential dangers or threats. This communication happens through paracrine (local) or endocrine (system-wide) pathways.

    Signup and view all the flashcards

    Drought Tolerance

    The ability of certain plants, like resurrection plants, to survive extreme drought conditions, unlike non-resurrection plants.

    Signup and view all the flashcards

    Resurrection Plants

    Resurrection plants like Boea hygrometrica are able to survive severe drought by undergoing specific adaptations that allow them to maintain their water content.

    Signup and view all the flashcards

    Relative Water Content (RWC)

    A measure of the water content in a plant, indicating its hydration level.

    Signup and view all the flashcards

    Non-Resurrection Plants

    A plant that does not have the ability to survive extreme drought conditions, like Arabidopsis thaliana.

    Signup and view all the flashcards

    Cell Shrinkage and Folding

    The process of cell shrinking and membrane folding caused by water loss, a key step for survival in dehydration for plants.

    Signup and view all the flashcards

    Apoplastic Signaling

    Signaling pathways that activate the necessary protection and repair mechanisms in resurrection plants, mainly through changes within the cell walls.

    Signup and view all the flashcards

    Autophagy in Resurrection Plants

    A crucial cellular recycling process activated in resurrection plants to break down and remove damaged cellular components under dehydration.

    Signup and view all the flashcards

    Photosynthetic Shutdown

    The shutdown of photosynthesis as a survival mechanism in resurrection plants during dehydration, conserving energy and preventing damage.

    Signup and view all the flashcards

    Alternative Oxidase Upregulation

    An alternative energy pathway used in resurrection plants during dehydration, providing energy when photosynthesis is halted.

    Signup and view all the flashcards

    Leaf Shrinkage and Curling

    The outward manifestations of water loss in resurrection plants, including shrinking and curling of leaves, which help to reduce water loss and protect the plant.

    Signup and view all the flashcards

    Resurrection Plant Resilience

    The ability of resurrection plants to survive extreme dehydration and revive when water becomes available, a unique adaptation to arid environments.

    Signup and view all the flashcards

    Water Loss and its Effects on Plants

    The process of water loss that impacts the survival strategies of both resurrection and non-resurrection plants, leading to contrasting responses.

    Signup and view all the flashcards

    Study Notes

    Cellular Adaptation to Environmental Stress

    • Cellular adaptation refers to the reversible changes in cell structure or function in response to environmental stimuli.
    • Homeostasis is a steady state where cells function optimally, and physiological needs are met.
    • Stress, or increased demand, can lead to an inability to adapt, resulting in cell injury and, ultimately, cell death.
    • Adaptation is a cellular response to various stimuli.

    Types of Cellular Adaptations

    • Hypertrophy: Increased size of cells.
    • Hyperplasia: Increased number of cells.
    • Atrophy: Decreased size and function of cells.
    • Metaplasia: Transformation of one cell type into another.
    • Displasia: Disordered growth and maturation of cells.

    Cellular Injury Responses

    • Reversible injury: Cells can recover if the injurious stimulus is removed.
    • Mild injury: Cells can adapt via hypertrophy, hyperplasia, atrophy, metaplasia.
    • Severe injury: Cell injury progresses to irreversible injury.
    • Irreversible injury: Cells cannot recover, leading to necrosis or apoptosis.
    • Necrosis: Pre-programmed cell death caused by external factors.
    • Apoptosis: Pre-programmed cell death caused by internal factors.

    Mechanisms of Cellular Injury

    • Reduced oxygen supply: Ischemia, hypoxia.
    • Chemical injury: Substances damaging cell structures/functions.
    • Infections: Viruses, bacteria etc.
    • Immunologic responses: Reactions to foreign bodies.
    • Genetic defects: Gene mutations, faulty protein synthesis.
    • Nutritional imbalances: Deficiencies or excesses impacting cell functions.
    • Mitochondrial damage: Loss of ATP production.
    • Calcium imbalance: Imbalances affecting cellular proteins and enzymes.
    • Reactive oxygen species (ROS): Increased levels damage cells.

    Role of Mitochondria in Cellular Injury

    • Mitochondria play a vital role in cellular ATP production.
    • Mitochondrial damage leads to a reduced ATP supply and increased ROS production, subsequently impairing numerous cellular processes.

    Summary of Cellular Injury

    • A diverse range of factors can lead to cellular injury.
    • Reversible changes are possible.
    • Severe and sustained injury can lead to cell death.
    • Necrosis and apoptosis are distinct processes of programmed cell death, each triggered differently and involved in distinct biological consequences.

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Related Documents

    Description

    Explore the mechanisms of cellular adaptation and the types of responses to environmental stressors. This quiz covers key concepts such as hypertrophy, hyperplasia, and cellular injury. Understand how these adaptations contribute to cell health and function.

    More Like This

    Physiological Adaptations and Cell Injury
    53 questions
    Cellular Injury and Adaptation Quiz
    32 questions
    Use Quizgecko on...
    Browser
    Browser