Cellular Adaptation and Injury Quiz

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Questions and Answers

What is the steady structural and functional state maintained by a normal cell known as?

  • Cell injury
  • Pathologic stimuli
  • Homeostasis (correct)
  • Adaptation

Which type of adaptation is exemplified by denervation atrophy of skeletal muscles?

  • Pathologic adaptation (correct)
  • Cell injury
  • Physiologic adaptation
  • Homeostasis

What occurs if the limits of adaptive capability are exceeded, or no adaptive response is possible?

  • Cell injury (correct)
  • Physiologic adaptation
  • Homeostasis
  • Pathologic adaptation

Which type of cells are permanently in G0 phase and unable to divide?

<p>Neurons (A)</p> Signup and view all the answers

Which type of cells can enter the cell cycle upon stimulation and can undergo hyperplasia and hypertrophy?

<p>Stable cells (A)</p> Signup and view all the answers

Which type of cells are continuously dividing and can only undergo hyperplasia?

<p>Labile cells (D)</p> Signup and view all the answers

Which of the following is an example of physiologic hypertrophy?

<p>Skeletal muscles in athletes (D)</p> Signup and view all the answers

In which condition does physiologic hypertrophy occur?

<p>Myometrium during pregnancy (A)</p> Signup and view all the answers

Which of the following is an example of physiologic hypertrophy in the breast?

<p>Ductal epithelium in the lactating breast (A)</p> Signup and view all the answers

Which type of hypertrophy occurs in the right ventricular myocardium in chronic pulmonary diseases with increased resistance in the pulmonary circulation?

<p>Pathologic hypertrophy (C)</p> Signup and view all the answers

What is the cause of pathologic hypertrophy in the left ventricular myocardium in hypertension?

<p>Increased mechanical demand (C)</p> Signup and view all the answers

In response to which factor does pathologic hypertrophy develop in the myocardium?

<p>Increased mechanical demand (C)</p> Signup and view all the answers

Which pathway is activated in physiologic conditions to induce skeletal/cardiac muscle hypertrophy in response to increased mechanical load?

<p>PI3K/AKT pathway (D)</p> Signup and view all the answers

What is the mechanism of mechanical-demand-induced hypertrophy in pathologic conditions?

<p>G-protein-coupled receptor-initiated pathway (C)</p> Signup and view all the answers

Which factor is involved in the activation of mechanical sensors to induce skeletal/cardiac muscle hypertrophy in response to increased mechanical load?

<p>Activation of signaling pathways (C)</p> Signup and view all the answers

Which organelle shows an increase in size and number during hypertrophy?

<p>Mitochondria (B)</p> Signup and view all the answers

What structural change is associated with nuclear hypertrophy?

<p>Increase in size of the nucleus (B)</p> Signup and view all the answers

In hypertrophy, what undergoes an increase in size and number as a form of cellular adaptation?

<p>Golgi apparatus (C)</p> Signup and view all the answers

Which of the following is an example of hormone-induced hyperplasia in physiologic conditions?

<p>Proliferation of glandular epithelium of the female breast during pregnancy (A)</p> Signup and view all the answers

Which type of hyperplasia coincides with hypertrophy in many organs?

<p>Physiologic hyperplasia (A)</p> Signup and view all the answers

In which condition does smooth muscle cell hyperplasia occur?

<p>During pregnancy (A)</p> Signup and view all the answers

What can cause hyperplasia of the submucosal glands in the bronchial wall?

<p>Viral infections (A)</p> Signup and view all the answers

Which type of hyperplasia is associated with endometrial hyperplasia?

<p>Excessive hormonal stimulation (B)</p> Signup and view all the answers

What can lead to benign prostate hyperplasia?

<p>Excessive hormonal stimulation (D)</p> Signup and view all the answers

Which of the following is a characteristic of pathologic hyperplasia?

<p>Occurs in response to abnormal stimuli (A)</p> Signup and view all the answers

What distinguishes neoplasia from hyperplasia?

<p>Does not respond to regulatory mechanisms (B)</p> Signup and view all the answers

Which type of hyperplasia is reversible?

<p>Physiologic hyperplasia (A)</p> Signup and view all the answers

What is the mechanism involved in atrophy due to decreased protein synthesis?

<p>Activation of the ubiquitin-proteasome pathway (B)</p> Signup and view all the answers

What is the result of atrophy involving lysosomal degradation?

<p>Formation of autophagic vacuoles (C)</p> Signup and view all the answers

What is the consequence of atrophy involving residual bodies containing lipofuscin?

<p>Increased protein degradation (D)</p> Signup and view all the answers

In the early stage of atrophy, what contributes to reduced cell size?

<p>Decreased number and size of organelles (D)</p> Signup and view all the answers

What is a characteristic of the advanced stage of atrophy?

<p>Cell death (apoptosis) (B)</p> Signup and view all the answers

What is the consequence of lipofuscin accumulation in atrophy?

<p>Brown atrophy (A)</p> Signup and view all the answers

Which structure undergoes physiologic atrophy during fetal development?

<p>Notochord (D)</p> Signup and view all the answers

Where does atrophy occur after menopause?

<p>Endometrium and breast (C)</p> Signup and view all the answers

Which muscle undergoes atrophy after delivery?

<p>Myometrium (D)</p> Signup and view all the answers

Which of the following structures undergoes physiologic atrophy during fetal development?

<p>Notochord (C)</p> Signup and view all the answers

After menopause, which of the following undergoes atrophy?

<p>Endometrium (C)</p> Signup and view all the answers

Which structure undergoes atrophy after delivery?

<p>Myometrium (A)</p> Signup and view all the answers

Which condition can lead to skeletal muscle atrophy?

<p>Bone fracture (D)</p> Signup and view all the answers

What can cause atrophy of target organs like the thyroid or adrenal glands?

<p>Pressure atrophy (B)</p> Signup and view all the answers

Which factor can lead to organ atrophy due to chronic ischemia?

<p>Protein metabolism abnormalities (A)</p> Signup and view all the answers

What is an example of pressure atrophy according to the given text?

<p>Urolithiasis causing kidney atrophy (D)</p> Signup and view all the answers

What can result in brain atrophy according to the given text?

<p>Hydrocephalus (A)</p> Signup and view all the answers

What is the consequence of obstruction to urinary flow as per the given text?

<p>Hydronephrosis (B)</p> Signup and view all the answers

Which condition is characterized by severe caloric deficiency leading to generalized atrophy?

<p>Marasmus (B)</p> Signup and view all the answers

What is the consequence of severe protein-caloric deficiency in Kwashiorkor?

<p>Generalized edema (C)</p> Signup and view all the answers

In which group of patients is TNF release commonly observed due to severe acute malnutrition?

<p>Patients with cancer and chronic infectious diseases (B)</p> Signup and view all the answers

What is the purpose of metaplasia as mentioned in the text?

<p>To withstand the action of a harmful stimulus (D)</p> Signup and view all the answers

What is the clinical significance of epithelial metaplasia according to the text?

<p>It provides a background for malignant transformation (B)</p> Signup and view all the answers

In metaplasia, replacement of one adult cell type by another occurs within which parameter as mentioned in the text?

<p>Within the same germ layer (D)</p> Signup and view all the answers

Which of the following is an example of metaplasia in the respiratory system?

<p>Transformation of columnar epithelium to non-keratinizing squamous epithelium in the bronchi (B)</p> Signup and view all the answers

What is a clinically significant example of metaplasia in the uterine cervix?

<p>Transition of columnar epithelium to non-keratinizing squamous epithelium (A)</p> Signup and view all the answers

Which of the following represents a metaplastic change associated with Barrett esophagus?

<p>Non-keratinizing squamous epithelium to columnar/intestinal epithelium (A)</p> Signup and view all the answers

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