Cellular Adaptation and Injury Quiz
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Questions and Answers

What is the steady structural and functional state maintained by a normal cell known as?

  • Cell injury
  • Pathologic stimuli
  • Homeostasis (correct)
  • Adaptation
  • Which type of adaptation is exemplified by denervation atrophy of skeletal muscles?

  • Pathologic adaptation (correct)
  • Cell injury
  • Physiologic adaptation
  • Homeostasis
  • What occurs if the limits of adaptive capability are exceeded, or no adaptive response is possible?

  • Cell injury (correct)
  • Physiologic adaptation
  • Homeostasis
  • Pathologic adaptation
  • Which type of cells are permanently in G0 phase and unable to divide?

    <p>Neurons</p> Signup and view all the answers

    Which type of cells can enter the cell cycle upon stimulation and can undergo hyperplasia and hypertrophy?

    <p>Stable cells</p> Signup and view all the answers

    Which type of cells are continuously dividing and can only undergo hyperplasia?

    <p>Labile cells</p> Signup and view all the answers

    Which of the following is an example of physiologic hypertrophy?

    <p>Skeletal muscles in athletes</p> Signup and view all the answers

    In which condition does physiologic hypertrophy occur?

    <p>Myometrium during pregnancy</p> Signup and view all the answers

    Which of the following is an example of physiologic hypertrophy in the breast?

    <p>Ductal epithelium in the lactating breast</p> Signup and view all the answers

    Which type of hypertrophy occurs in the right ventricular myocardium in chronic pulmonary diseases with increased resistance in the pulmonary circulation?

    <p>Pathologic hypertrophy</p> Signup and view all the answers

    What is the cause of pathologic hypertrophy in the left ventricular myocardium in hypertension?

    <p>Increased mechanical demand</p> Signup and view all the answers

    In response to which factor does pathologic hypertrophy develop in the myocardium?

    <p>Increased mechanical demand</p> Signup and view all the answers

    Which pathway is activated in physiologic conditions to induce skeletal/cardiac muscle hypertrophy in response to increased mechanical load?

    <p>PI3K/AKT pathway</p> Signup and view all the answers

    What is the mechanism of mechanical-demand-induced hypertrophy in pathologic conditions?

    <p>G-protein-coupled receptor-initiated pathway</p> Signup and view all the answers

    Which factor is involved in the activation of mechanical sensors to induce skeletal/cardiac muscle hypertrophy in response to increased mechanical load?

    <p>Activation of signaling pathways</p> Signup and view all the answers

    Which organelle shows an increase in size and number during hypertrophy?

    <p>Mitochondria</p> Signup and view all the answers

    What structural change is associated with nuclear hypertrophy?

    <p>Increase in size of the nucleus</p> Signup and view all the answers

    In hypertrophy, what undergoes an increase in size and number as a form of cellular adaptation?

    <p>Golgi apparatus</p> Signup and view all the answers

    Which of the following is an example of hormone-induced hyperplasia in physiologic conditions?

    <p>Proliferation of glandular epithelium of the female breast during pregnancy</p> Signup and view all the answers

    Which type of hyperplasia coincides with hypertrophy in many organs?

    <p>Physiologic hyperplasia</p> Signup and view all the answers

    In which condition does smooth muscle cell hyperplasia occur?

    <p>During pregnancy</p> Signup and view all the answers

    What can cause hyperplasia of the submucosal glands in the bronchial wall?

    <p>Viral infections</p> Signup and view all the answers

    Which type of hyperplasia is associated with endometrial hyperplasia?

    <p>Excessive hormonal stimulation</p> Signup and view all the answers

    What can lead to benign prostate hyperplasia?

    <p>Excessive hormonal stimulation</p> Signup and view all the answers

    Which of the following is a characteristic of pathologic hyperplasia?

    <p>Occurs in response to abnormal stimuli</p> Signup and view all the answers

    What distinguishes neoplasia from hyperplasia?

    <p>Does not respond to regulatory mechanisms</p> Signup and view all the answers

    Which type of hyperplasia is reversible?

    <p>Physiologic hyperplasia</p> Signup and view all the answers

    What is the mechanism involved in atrophy due to decreased protein synthesis?

    <p>Activation of the ubiquitin-proteasome pathway</p> Signup and view all the answers

    What is the result of atrophy involving lysosomal degradation?

    <p>Formation of autophagic vacuoles</p> Signup and view all the answers

    What is the consequence of atrophy involving residual bodies containing lipofuscin?

    <p>Increased protein degradation</p> Signup and view all the answers

    In the early stage of atrophy, what contributes to reduced cell size?

    <p>Decreased number and size of organelles</p> Signup and view all the answers

    What is a characteristic of the advanced stage of atrophy?

    <p>Cell death (apoptosis)</p> Signup and view all the answers

    What is the consequence of lipofuscin accumulation in atrophy?

    <p>Brown atrophy</p> Signup and view all the answers

    Which structure undergoes physiologic atrophy during fetal development?

    <p>Notochord</p> Signup and view all the answers

    Where does atrophy occur after menopause?

    <p>Endometrium and breast</p> Signup and view all the answers

    Which muscle undergoes atrophy after delivery?

    <p>Myometrium</p> Signup and view all the answers

    Which of the following structures undergoes physiologic atrophy during fetal development?

    <p>Notochord</p> Signup and view all the answers

    After menopause, which of the following undergoes atrophy?

    <p>Endometrium</p> Signup and view all the answers

    Which structure undergoes atrophy after delivery?

    <p>Myometrium</p> Signup and view all the answers

    Which condition can lead to skeletal muscle atrophy?

    <p>Bone fracture</p> Signup and view all the answers

    What can cause atrophy of target organs like the thyroid or adrenal glands?

    <p>Pressure atrophy</p> Signup and view all the answers

    Which factor can lead to organ atrophy due to chronic ischemia?

    <p>Protein metabolism abnormalities</p> Signup and view all the answers

    What is an example of pressure atrophy according to the given text?

    <p>Urolithiasis causing kidney atrophy</p> Signup and view all the answers

    What can result in brain atrophy according to the given text?

    <p>Hydrocephalus</p> Signup and view all the answers

    What is the consequence of obstruction to urinary flow as per the given text?

    <p>Hydronephrosis</p> Signup and view all the answers

    Which condition is characterized by severe caloric deficiency leading to generalized atrophy?

    <p>Marasmus</p> Signup and view all the answers

    What is the consequence of severe protein-caloric deficiency in Kwashiorkor?

    <p>Generalized edema</p> Signup and view all the answers

    In which group of patients is TNF release commonly observed due to severe acute malnutrition?

    <p>Patients with cancer and chronic infectious diseases</p> Signup and view all the answers

    What is the purpose of metaplasia as mentioned in the text?

    <p>To withstand the action of a harmful stimulus</p> Signup and view all the answers

    What is the clinical significance of epithelial metaplasia according to the text?

    <p>It provides a background for malignant transformation</p> Signup and view all the answers

    In metaplasia, replacement of one adult cell type by another occurs within which parameter as mentioned in the text?

    <p>Within the same germ layer</p> Signup and view all the answers

    Which of the following is an example of metaplasia in the respiratory system?

    <p>Transformation of columnar epithelium to non-keratinizing squamous epithelium in the bronchi</p> Signup and view all the answers

    What is a clinically significant example of metaplasia in the uterine cervix?

    <p>Transition of columnar epithelium to non-keratinizing squamous epithelium</p> Signup and view all the answers

    Which of the following represents a metaplastic change associated with Barrett esophagus?

    <p>Non-keratinizing squamous epithelium to columnar/intestinal epithelium</p> Signup and view all the answers

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