Cell Wall Biosynthesis Final Cross-Linking Reaction
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Questions and Answers

Which type of antibiotics do Penicillins and Cephalosporins belong to?

  • Sulfonamide antibiotics
  • β-lactam antibiotics (correct)
  • Non-steroidal antibiotics
  • Macrolide antibiotics

What is the common structural feature found in β-lactam antibiotics?

  • Pyrimidine ring
  • Cyclohexane ring
  • β-lactam ring (correct)
  • Benzene ring

What is the structure of the cell wall that Penicillins and Cephalosporins selectively inhibit?

  • Cholesterol layer
  • Peptidoglycan structure (correct)
  • Protein matrix
  • Lipid bilayer

Which reference provides information about the Organic Chemistry of Drug Design and Drug Action?

<p>B. Silverman, The Organic Chemistry of Drug Design and Drug Action (A)</p> Signup and view all the answers

What is the primary mechanism of action of Penicillins and Cephalosporins?

<p>Inhibition of bacterial cell wall synthesis (D)</p> Signup and view all the answers

Which book is known for providing information on The Pharmacological Basis of Therapeutics?

<p>Goodman and Gilman's The Pharmacological Basis of Therapeutics (D)</p> Signup and view all the answers

What is the main reason for the acid sensitivity of penicillin G?

<p>Influence of the acyl chain (B)</p> Signup and view all the answers

Which component in penicillin G contributes to its acid sensitivity due to ring strain?

<p>Folded ring structure (D)</p> Signup and view all the answers

What structural feature of penicillin V enables it to have better acid stability than penicillin G?

<p>Presence of an electronegative oxygen on the acyl side chain (A)</p> Signup and view all the answers

Which type of penicillin is sensitive to penicillinases and slightly less active than penicillin G?

<p>Ampicillin (C)</p> Signup and view all the answers

What is responsible for the high reactivity of the β-lactam carbonyl group in penicillin G?

<p>Folded ring structure (C)</p> Signup and view all the answers

What characteristic makes penicillin V less active than penicillin G?

<p>Presence of an electronegative oxygen on the acyl side chain (D)</p> Signup and view all the answers

Which of the following is NOT one of the simplified forms of Penicillin nomenclature mentioned in the text?

<p>Trivial nomenclature using penicillin as a prefix (B)</p> Signup and view all the answers

What is the chemical structure of Benzylpenicillin (Penicillin G) based on the provided information?

<p>6-aminopenicillanic acid derivative (D)</p> Signup and view all the answers

What does the acronym '6-APA' stand for in the context of Penicillin nomenclature?

<p>6-Aminopenicillanic Acid (D)</p> Signup and view all the answers

Which part of the Penicillin molecule is described by the trivial nomenclature using the name penicillin as a suffix?

<p>Thiazolidine ring (D)</p> Signup and view all the answers

What is the common feature among all three simplified forms of Penicillin nomenclature mentioned in the text?

<p>Reference to 6-aminopenicillanic acid (B)</p> Signup and view all the answers

What is unique about the chemical structure of Phenoxymethylpenicillin (Penicillin V) compared to other Penicillins?

<p>Acyl side chain consisting of valine (A)</p> Signup and view all the answers

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