Cell Wall Biosynthesis Final Cross-Linking Reaction
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Questions and Answers

Which type of antibiotics do Penicillins and Cephalosporins belong to?

  • Sulfonamide antibiotics
  • β-lactam antibiotics (correct)
  • Non-steroidal antibiotics
  • Macrolide antibiotics
  • What is the common structural feature found in β-lactam antibiotics?

  • Pyrimidine ring
  • Cyclohexane ring
  • β-lactam ring (correct)
  • Benzene ring
  • What is the structure of the cell wall that Penicillins and Cephalosporins selectively inhibit?

  • Cholesterol layer
  • Peptidoglycan structure (correct)
  • Protein matrix
  • Lipid bilayer
  • Which reference provides information about the Organic Chemistry of Drug Design and Drug Action?

    <p>B. Silverman, The Organic Chemistry of Drug Design and Drug Action</p> Signup and view all the answers

    What is the primary mechanism of action of Penicillins and Cephalosporins?

    <p>Inhibition of bacterial cell wall synthesis</p> Signup and view all the answers

    Which book is known for providing information on The Pharmacological Basis of Therapeutics?

    <p>Goodman and Gilman's The Pharmacological Basis of Therapeutics</p> Signup and view all the answers

    What is the main reason for the acid sensitivity of penicillin G?

    <p>Influence of the acyl chain</p> Signup and view all the answers

    Which component in penicillin G contributes to its acid sensitivity due to ring strain?

    <p>Folded ring structure</p> Signup and view all the answers

    What structural feature of penicillin V enables it to have better acid stability than penicillin G?

    <p>Presence of an electronegative oxygen on the acyl side chain</p> Signup and view all the answers

    Which type of penicillin is sensitive to penicillinases and slightly less active than penicillin G?

    <p>Ampicillin</p> Signup and view all the answers

    What is responsible for the high reactivity of the β-lactam carbonyl group in penicillin G?

    <p>Folded ring structure</p> Signup and view all the answers

    What characteristic makes penicillin V less active than penicillin G?

    <p>Presence of an electronegative oxygen on the acyl side chain</p> Signup and view all the answers

    Which of the following is NOT one of the simplified forms of Penicillin nomenclature mentioned in the text?

    <p>Trivial nomenclature using penicillin as a prefix</p> Signup and view all the answers

    What is the chemical structure of Benzylpenicillin (Penicillin G) based on the provided information?

    <p>6-aminopenicillanic acid derivative</p> Signup and view all the answers

    What does the acronym '6-APA' stand for in the context of Penicillin nomenclature?

    <p>6-Aminopenicillanic Acid</p> Signup and view all the answers

    Which part of the Penicillin molecule is described by the trivial nomenclature using the name penicillin as a suffix?

    <p>Thiazolidine ring</p> Signup and view all the answers

    What is the common feature among all three simplified forms of Penicillin nomenclature mentioned in the text?

    <p>Reference to 6-aminopenicillanic acid</p> Signup and view all the answers

    What is unique about the chemical structure of Phenoxymethylpenicillin (Penicillin V) compared to other Penicillins?

    <p>Acyl side chain consisting of valine</p> Signup and view all the answers

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