18 Questions
Which type of antibiotics do Penicillins and Cephalosporins belong to?
β-lactam antibiotics
What is the common structural feature found in β-lactam antibiotics?
β-lactam ring
What is the structure of the cell wall that Penicillins and Cephalosporins selectively inhibit?
Peptidoglycan structure
Which reference provides information about the Organic Chemistry of Drug Design and Drug Action?
B. Silverman, The Organic Chemistry of Drug Design and Drug Action
What is the primary mechanism of action of Penicillins and Cephalosporins?
Inhibition of bacterial cell wall synthesis
Which book is known for providing information on The Pharmacological Basis of Therapeutics?
Goodman and Gilman's The Pharmacological Basis of Therapeutics
What is the main reason for the acid sensitivity of penicillin G?
Influence of the acyl chain
Which component in penicillin G contributes to its acid sensitivity due to ring strain?
Folded ring structure
What structural feature of penicillin V enables it to have better acid stability than penicillin G?
Presence of an electronegative oxygen on the acyl side chain
Which type of penicillin is sensitive to penicillinases and slightly less active than penicillin G?
Ampicillin
What is responsible for the high reactivity of the β-lactam carbonyl group in penicillin G?
Folded ring structure
What characteristic makes penicillin V less active than penicillin G?
Presence of an electronegative oxygen on the acyl side chain
Which of the following is NOT one of the simplified forms of Penicillin nomenclature mentioned in the text?
Trivial nomenclature using penicillin as a prefix
What is the chemical structure of Benzylpenicillin (Penicillin G) based on the provided information?
6-aminopenicillanic acid derivative
What does the acronym '6-APA' stand for in the context of Penicillin nomenclature?
6-Aminopenicillanic Acid
Which part of the Penicillin molecule is described by the trivial nomenclature using the name penicillin as a suffix?
Thiazolidine ring
What is the common feature among all three simplified forms of Penicillin nomenclature mentioned in the text?
Reference to 6-aminopenicillanic acid
What is unique about the chemical structure of Phenoxymethylpenicillin (Penicillin V) compared to other Penicillins?
Acyl side chain consisting of valine
Learn about the final step in cell wall biosynthesis where peptide chains are linked by the displacement of D-alanine by glycine. Discover how this process is inhibited by penicillins and cephalosporins.
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