Untitled Quiz

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Which type of antibiotic is vancomycin?

Polypeptide

Beta-lactam

Glycopeptide (correct)

Polyene

At what concentration is vancomycin bactericidal to all susceptible bacteria?

No specific concentration

At its MIC (correct)

Below its MIC

Above its MIC

What problem has arisen due to the development of Vancomycin Resistant enterococci (VRE)?

Emergence of a common hospital-acquired infection (correct)

Increased effectiveness of vancomycin

Decreased toxicity of vancomycin

Improved treatment options for MRSA

Which antibiotic inhibits cell wall synthesis at an early stage by interfering with bactoprenol?

Bacitracin Signup and view all the answers

What characteristic is responsible for the acid-fast staining in mycobacteria?

Lipid-rich nature Signup and view all the answers

Which antibiotics are commonly used to treat mycobacterial infections like tuberculosis?

Isoniazid and Ethambutol Signup and view all the answers

What is the mechanism of action of D-cycloserine in interfering with bacterial cell wall synthesis?

Competitively inhibiting L-alanine racemase and D-alanine:D-alanine ligase Signup and view all the answers

How does Vancomycin inhibit peptidoglycan formation necessary for bacterial cell wall synthesis?

Preventing the precursors from crossing the cell membrane Signup and view all the answers

Why can't Glycopeptides like Vancomycin effectively inhibit gram-negative bacteria?

Their molecular size prevents them from crossing the cell wall Signup and view all the answers

Which enzymes are responsible for polymerizing glycan chains and catalyzing peptide cross-linking in peptidoglycan macromolecule assembly?

Transglycosylase and transpeptidase Signup and view all the answers

What is the role of lipid carrier molecules in peptidoglycan biosynthesis?

Transporting precursors across the cytoplasmic membrane Signup and view all the answers

How does Glycopeptide antibiotics like Vancomycin block peptidoglycan synthesis in bacterial cell walls?

By preventing extension of linear glycan peptides in the cell wall Signup and view all the answers

What is the mechanism of action of ß-Lactam antibiotics in inhibiting the transpeptidase enzyme?

They mimic the D-alanyl-D-alanin residues and react covalently with transpeptidase Signup and view all the answers

Which type of bacteria are ß-Lactam antibiotics generally active against?

Gram-positive bacteria Signup and view all the answers

Which of the following antibiotics is NOT active against Pseudomonas aeruginosa?

Penicillin Signup and view all the answers

Which group of penicillins is effective against both Gram-negative and Gram-positive bacteria?

Extended Spectrum Penicillins Signup and view all the answers

What characteristic makes Extended Spectrum Penicillins different from other penicillins?

They overcome narrow spectrum problems Signup and view all the answers

Which of the following is true about Carboxypenicillins like carbenicillin?

They are not effective against Pseudomonas aeruginosa Signup and view all the answers