Podcast
Questions and Answers
What is cell injury?
What is cell injury?
A sequence of events (biochemical & morphologic) upon exposure of the cell to injurious agent
What are the main causes of cell injury?
What are the main causes of cell injury?
The effect of cell injury is determined by the severity and duration of the injurious agent as well as the cell's vulnerability.
The effect of cell injury is determined by the severity and duration of the injurious agent as well as the cell's vulnerability.
True
What are the types of cell injury?
What are the types of cell injury?
Signup and view all the answers
Which of the following describe signs of reversible cell injury?
Which of the following describe signs of reversible cell injury?
Signup and view all the answers
What is the name for a type of irreversible cell injury that involves cell death through a process of programmed cell death?
What is the name for a type of irreversible cell injury that involves cell death through a process of programmed cell death?
Signup and view all the answers
Fatty change in liver cells often shows a 'signet ring appearance' under a microscope.
Fatty change in liver cells often shows a 'signet ring appearance' under a microscope.
Signup and view all the answers
What does 'degeneration' mean in terms of cell injury?
What does 'degeneration' mean in terms of cell injury?
Signup and view all the answers
Study Notes
Cell Response to Injury
- The lecture is about cell response to injury
- Key learning objectives include:
- Defining cell injury
- Identifying the causes of cell injury
- Understanding different types of cell injury
Cell Injury Definition
- Cell injury is a sequence of biochemical and morphological events following exposure of the cell to an injurious agent.
- Involves both biochemical and morphological changes
Causes of Cell Injury
- Hypoxia: Oxygen deficiency, commonly due to ischemia (impaired blood supply), inadequate oxygenation, or anemia (loss of oxygen-carrying capacity).
- Physical Agents: Trauma, radiation, extreme temperatures, electric shock
- Chemical Agents: Acids, alkalis, animal and plant poisons
- Microbiological Agents: Viruses, bacteria, parasites
- Immunologic Reactions: Allergic reactions, autoimmune diseases
Effects of Cell Injury
- The severity and duration of the injurious agent influence the effect on the cell.
-
Adaptation: The body's response to mild injury, which can be:
- Hyperplasia: Increased cell number
- Hypertrophy: Increased cell size
- Metaplasia: Conversion of one cell type to another
-
Injury: Occurs if adaptation cannot counteract the stressor, leading to:
- Reversible Injury: Mild, transient changes potentially reversible if the stimulus is removed. Examples: cloudy swelling, fatty change.
- Irreversible Injury: Severe, progressive damage leading to cell death, including necrosis and apoptosis.
Types of Cell Injury
-
Reversible Injury
- Cloudy Swelling: Characterized by water accumulation in cells (cytoplasm shows swelling)
- Fatty Change: Pathological accumulation of fat in parenchymal cells (e.g., liver cells)
-
Irreversible Injury
- Necrosis: Cell death characterized by cell lysis (cell bursting)
- Apoptosis: Cell suicide or programmed cell death (controlled process)
Additional Information
- Specific details about organs affected by cloudy swelling and hydropic swelling include the Kidney, Liver, Heart, and Skin.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Related Documents
Description
Test your understanding of cell injury, its causes, and the effects on cellular function. This quiz covers key concepts such as hypoxia, physical and chemical agents, and the biochemical changes involved in cell damage. Prepare to enhance your knowledge on this vital topic in pathology.
