Cell Injury 2024 PDF

- Definition of cell injury - Causes of cell injury -Types of cell injury:  Cell injury Definition: A sequence of events ( biochemical & morphologic) upon exposure of the cell to injurious agent injurious agents...

- Definition of cell injury - Causes of cell injury -Types of cell injury:  Cell injury Definition: A sequence of events ( biochemical & morphologic) upon exposure of the cell to injurious agent injurious agents Morphologic Biochemical changes Changes Causes of cell injury  Effects of cell injury Injurious agents Severity & duration of Cell Effect of injurious vulnerability cell injury agent Adaptation Injury  Effects of cell injury Injurious agents Minor More severe Injury injury Adaptation Injury In ability to adapt Hyperplasia Hypertrophy Metaplasia Effects of cell injury  Types of cell injury Cell death Cellular swelling t Fatty change  Types of cell injury Reversible cell injury Irreversible cell injury (Degeneration) (Cell Death) Severity of injurious Mild injury Severe injury agent Duration of injurious Short duration. Long duration. agent Includes a) Cellular swelling a) Necrosis (cloudy swelling and b) Apoptosis hydropic swelling). b) Fatty change  Reversible cell injury Accumulation t Reversible cell injury Reversible cell injury Characterized by accumulation of Small amount water in the cells Causing cellular swelling  Reversible cell injury Organs affected & microscopic picture : 1- Size: cell swelling Liver 2- Cytoplasm: fine granules Kidney Heart  Reversible cell injury Liver No significant Clinical Picture: Kidney change Proteinuria Heart Dilatation  Reversible cell injury Fate:  Reversible cell injury large Injurious agents Persistence of Injurious agents  Reversible cell injury Organs affected & microscopic picture : 1- Size: cell swelling 2- Cytoplasm: Lage clear vacuoles Liver Skin Kidney Viral hepatitis Viral Infection Renal tubule Allergic, Burns epithelium  Reversible cell injury Definition: Reversible cell injury characterized by pathological accumulation of excess fat in parenchymatous cells. Sites: most commonly affect liver. It also affect heart, kidney & muscles Injurious agents  Reversible cell injury Causes: Excess fat in diet Viral hepatitis Reversible cell injury the cytoplasm of Signet ring shape A- Degeneration means: a. Irreversible cell injury c- Abnormal cell injury b. Reversible cell injury d- Necrosis of the cells B-Liver cells with fat accumulation showed: a. Signet ring appearance c- Moth eaten appearance b. Spindle nuclei d-Inclusion bodies Definition: