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Questions and Answers
What is the primary structural component that makes up the cell membrane?
What is the primary structural component that makes up the cell membrane?
Which characteristic of a phospholipid molecule is critical to the formation of a membrane bilayer?
Which characteristic of a phospholipid molecule is critical to the formation of a membrane bilayer?
What is the main outcome of a cell membrane being described as a 'fluid mosaic'?
What is the main outcome of a cell membrane being described as a 'fluid mosaic'?
How does temperature influence the fluidity of a cell membrane?
How does temperature influence the fluidity of a cell membrane?
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How does the presence of unsaturated fatty acids in membrane phospholipids affect membrane fluidity?
How does the presence of unsaturated fatty acids in membrane phospholipids affect membrane fluidity?
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What role does cholesterol play in regulating membrane fluidity at warm temperatures?
What role does cholesterol play in regulating membrane fluidity at warm temperatures?
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What is the most likely reason for variations in the lipid composition of cell membranes among different species?
What is the most likely reason for variations in the lipid composition of cell membranes among different species?
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What is the primary function of integral membrane proteins?
What is the primary function of integral membrane proteins?
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What is the primary function of a contractile vacuole in a protist like Paramecium?
What is the primary function of a contractile vacuole in a protist like Paramecium?
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In a hypertonic environment, what is the correct result in an animal cell?
In a hypertonic environment, what is the correct result in an animal cell?
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What is the term for the condition when a plant cell's plasma membrane pulls away from the cell wall in a hypertonic solution?
What is the term for the condition when a plant cell's plasma membrane pulls away from the cell wall in a hypertonic solution?
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What type of protein facilitates the movement of water across a plasma membrane?
What type of protein facilitates the movement of water across a plasma membrane?
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Which of these options is not true about facilitated diffusion?
Which of these options is not true about facilitated diffusion?
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In an isotonic solution, what is the net movement of water across a cell membrane?
In an isotonic solution, what is the net movement of water across a cell membrane?
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What is the primary difference between channel proteins and carrier proteins in facilitated diffusion?
What is the primary difference between channel proteins and carrier proteins in facilitated diffusion?
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What is the main characteristic of active transport that differentiates it from passive transport?
What is the main characteristic of active transport that differentiates it from passive transport?
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What is the primary function of integral proteins within a cell membrane?
What is the primary function of integral proteins within a cell membrane?
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How does HIV enter cells based on the information?
How does HIV enter cells based on the information?
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Which type of molecule is most likely to freely pass through a cell membrane?
Which type of molecule is most likely to freely pass through a cell membrane?
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What are the two major types of molecules that can be covalently bonded to form membrane carbohydrates on the cell surface?
What are the two major types of molecules that can be covalently bonded to form membrane carbohydrates on the cell surface?
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What does the term 'dynamic equilibrium' refer to in the context of diffusion across a membrane?
What does the term 'dynamic equilibrium' refer to in the context of diffusion across a membrane?
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How does the cell membrane's structure contribute to its selective permeability?
How does the cell membrane's structure contribute to its selective permeability?
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What is the role of the ER and the Golgi apparatus in membrane formation?
What is the role of the ER and the Golgi apparatus in membrane formation?
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Which of the following accurately describes osmosis?
Which of the following accurately describes osmosis?
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What is the primary function of an electrogenic pump?
What is the primary function of an electrogenic pump?
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Which of the following best describes cotransport?
Which of the following best describes cotransport?
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What is the key difference between active and facilitated diffusion?
What is the key difference between active and facilitated diffusion?
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Which of these is a characteristic of bulk transport?
Which of these is a characteristic of bulk transport?
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Which of the following is true of the sodium-potassium pump?
Which of the following is true of the sodium-potassium pump?
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In which process does a cell engulf a particle by forming a vacuole?
In which process does a cell engulf a particle by forming a vacuole?
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Which of the following most accurately describes exocytosis?
Which of the following most accurately describes exocytosis?
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How does membrane potential relate to the movement of ions?
How does membrane potential relate to the movement of ions?
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Flashcards
Plasma Membrane
Plasma Membrane
The plasma membrane is a barrier that separates the inside of a cell from its environment.
Phospholipids
Phospholipids
The most abundant type of lipid in the cell membrane. They have a hydrophilic head and hydrophobic tails.
Fluid Mosaic Model
Fluid Mosaic Model
A model describing the structure of the cell membrane. It emphasizes that the membrane is fluid and contains a variety of proteins.
Passive Transport
Passive Transport
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Active Transport
Active Transport
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Exocytosis
Exocytosis
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Endocytosis
Endocytosis
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Integral Proteins
Integral Proteins
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Peripheral proteins
Peripheral proteins
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Transmembrane proteins
Transmembrane proteins
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Selective permeability
Selective permeability
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Diffusion
Diffusion
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Osmosis
Osmosis
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Carrier proteins
Carrier proteins
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Channel proteins
Channel proteins
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Tonicity
Tonicity
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Isotonic Solution
Isotonic Solution
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Hypertonic Solution
Hypertonic Solution
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Hypotonic Solution
Hypotonic Solution
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Osmoregulation
Osmoregulation
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Facilitated Diffusion
Facilitated Diffusion
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Electrogenic pump
Electrogenic pump
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Cotransport
Cotransport
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Symport
Symport
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Antiport
Antiport
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Phagocytosis
Phagocytosis
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Pinocytosis
Pinocytosis
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Study Notes
Biological Membranes
- Cellular membranes are fluid mosaics of lipids and proteins
- Membrane structure results in selective permeability
- Passive transport is the diffusion of a substance across a membrane, without requiring energy investment
- Active transport uses energy to move solutes against their gradients
- Bulk transport across the plasma membrane occurs by exocytosis and endocytosis
Fluid Mosaic Model
- Membranes are fluid structures with a "mosaic" of proteins embedded within the lipid bilayer
- Phospholipids in the plasma membrane can move within the bilayer
- Rarely, a molecule flips-flops transversely
Phospholipid Bilayers
- The plasma membrane separates a living cell from its surroundings
- Phospholipids are the most abundant lipids in the plasma membrane
- Phospholipids are amphipathic molecules, possessing both hydrophobic and hydrophilic regions
- Membranes are held together by weak hydrophobic interactions
Lipid Movement
- Phospholipids can move within the bilayer by flexion, rotation, and lateral diffusion
Protein Movement
- Proteins can move through the membrane
- Frye and Edidin’s experiment demonstrated protein mobility through labeling and fusing mouse and human cells
Fluidity of Membranes
- Membrane fluidity depends on temperature and lipid composition
- Membranes rich in unsaturated fatty acids are more fluid than those rich in saturated fatty acids
- Shorter hydrocarbon tails reduce the tendency of hydrocarbon tails to interact
Role of Steroids in Membrane Fluidity
- Cholesterol has different effects on membrane fluidity at different temperatures
- At warm temperatures, cholesterol restrains phospholipid movement, preventing the membrane from becoming too fluid
- At cool temperatures, cholesterol maintains fluidity by preventing tight packing
Peripheral and Integral Proteins
- Membranes consist of a collage of different proteins, like a tile mosaic
- Proteins determine most of the membrane's specific functions
- Peripheral proteins are bound to the membrane's surface
- Integral proteins penetrate the hydrophobic core and are embedded in the membrane
- Transmembrane proteins span the membrane
Functions of Membrane Proteins
- Membrane proteins have diverse functions, including transport, enzymatic activity, signal transduction, cell-cell recognition, intercellular joining, and attachment to the cytoskeleton and ECM
Membrane Proteins and HIV Resistance
- Cell surface proteins are important in medicine
- HIV must bind to CD4 and CCR5 to infect a cell
- Drugs have been developed to block CCR5, preventing HIV infection
The Role of Membrane Carbohydrates
- Cells recognize each other by binding to extracellular surface molecules, often containing carbohydrates
- Membrane carbohydrates are often covalently bonded to lipids (glycolipids) or proteins (glycoproteins)
Synthesis and Orientation
- Membranes have distinct inside and outside faces
- The asymmetrical distribution of plasma membrane components is determined during membrane synthesis by the ER and Golgi apparatus
Passive Transport
- Passive transport occurs through diffusion, and the cell does not have to expend energy
- Passive transport is facilitated by carrier proteins and channel proteins
Selective Permeability
- Cells must exchange materials with their surroundings, controlled by the plasma membrane
- The plasma membrane exhibits selective permeability, allowing some substances to cross more easily than others
- Hydrophobic (nonpolar) molecules can dissolve in the lipid bilayer and pass rapidly through the membrane
- Polar (hydrophilic) molecules do not easily cross the membrane
Diffusion
- Diffusion is the tendency for molecules to spread out evenly into available space
- Each molecule moves randomly, but diffusion of a population of molecules may be directional
- Dynamic equilibrium occurs when movement is equal in both directions
Osmosis
- Osmosis is the diffusion of water across a selectively permeable membrane
- Water diffuses from the region of lower solute concentration to the region of higher solute concentration until solute concentration is equal on both sides
Water Balance of Animal Cells
- Tonicity is the ability of a surrounding solution to cause a cell to gain or lose water
- Isotonic solution: Solute concentration is the same as inside the cell; no net water movement
- Hypertonic solution: Solute concentration is greater than inside the cell; cell loses water
- Hypotonic solution: Solute concentration is less than inside the cell; cell gains water
Water Balance of Plant Cells
- Cell walls help maintain water balance in plant cells
- Plant cell in hypotonic solution swells until the wall opposes uptake; it is turgid
- Plant cell in isotonic environment, no net movement of water; it is flaccid
- In a hypertonic environment, plant cells lose water, and plasmolysis occurs
Osmoregulation
- Hypertonic or hypotonic environments create osmotic problems for organisms
- Osmoregulation, the control of solute concentrations and water balance, is necessary for life
- The protist Paramecium, which is hypertonic to its pond water environment, has a contractile vacuole that acts as a pump
Facilitated Diffusion
- Transport proteins allow hydrophilic substances to pass across the membrane
- In facilitated diffusion, transport proteins aid the passive movement of molecules across the plasma membrane
- Transport proteins are specific for the substance they move
- Transport proteins are classified as channel or carrier proteins
Carriers and Channels
- Carrier proteins undergo a change in shape to translocate the solute-binding site across the membrane
- Channel proteins provide corridors for specific molecules or ions to cross
- Aquaporins facilitate the diffusion of water
- Ion channels can be gated, opening or closing in response to a stimulus
Active Transport
- Active transport moves solutes against their concentration gradient
- Active transport requires energy, usually in the form of ATP
- Examples of active transport include the sodium-potassium pump, electrogenic pump, and proton pump, as well as cotransport
Sodium-Potassium Pump
- The sodium-potassium pump is an active transport system
Electrochemical Gradient
- Membrane potential is the voltage difference across a membrane
- Two combined forces, chemical and electrical, create electrochemical gradients
- The electrochemical gradient drives ion diffusion across a membrane
- An electrogenic pump is a transport protein that generates voltage across a membrane
Proton Pump
- The proton pump is the major electrogenic pump in plants, fungi, and bacteria
Cotransport
- Cotransport occurs when active transport of one solute indirectly drives the transport of another solute
Bulk Transport
- Bulk transport requires energy
- For transport of large molecules
- Exocytosis and endocytosis
Exocytosis
- In exocytosis, transport vesicles migrate to the membrane, fuse with it, and release their contents to the outside of the cell
Endocytosis
- In endocytosis, the cell takes in macromolecules by forming vesicles from the plasma membrane
- There are three types: phagocytosis, pinocytosis and receptor-mediated endocytosis
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Description
Test your knowledge on the structural components and functions of cell membranes. This quiz covers topics such as phospholipid bilayers, membrane fluidity, and the role of proteins and cholesterol. Perfect for students in biology courses focused on cellular structure.