Cell Cycle and Proto-Oncogenes Quiz
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Questions and Answers

The cell cycle is independent of the activation and completion of previous phases.

False

If there is a deficiency in an essential gene function, the cell cycle continues uninterrupted.

False

Quiescent cells are in the physiological state Go.

True

The cell cycle does not have redundancies during the transition from G1 and S-phases.

<p>False</p> Signup and view all the answers

For any quiescent cell to enter the cell cycle, there must be activation of transcriptional genes.

<p>True</p> Signup and view all the answers

The cell cycle is not involved in tissue regeneration and repair.

<p>False</p> Signup and view all the answers

Proto-oncogenes, when functioning normally, play no role in the regulation of cell proliferation.

<p>False</p> Signup and view all the answers

Defective proto-oncogenes, known as oncogenes, have the potential to lead to cancer.

<p>True</p> Signup and view all the answers

Cell replication is not influenced by external growth factors or integrins in the extracellular matrix (ECM).

<p>False</p> Signup and view all the answers

The processes of DNA replication and cell division are tightly regulated within the cell cycle.

<p>True</p> Signup and view all the answers

In the order of cell development, differentiation occurs before proliferation.

<p>False</p> Signup and view all the answers

Study Notes

Proto-oncogenes and Cell Cycle Regulation

  • Proto-oncogenes are involved in regulating normal cell proliferation
  • Defects in proto-oncogenes can convert them to oncogenes, leading to cancer
  • Growth factors or integrins in the ECM stimulate cell replication

Cell Cycle Overview

  • The cell cycle consists of G1 (pre-synthetic), S (DNA synthesis), G2 (pre-mitotic), and M (mitotic) phases
  • Each phase depends on proper activation and completion of the previous one
  • The cell cycle is essential for maintaining tissue homeostasis and regulating physiologic growth processes
  • It is also involved in tissue regeneration and repair

Quiescent Cells and Cell Cycle Entry

  • Quiescent cells (e.g., hepatocytes) can enter the cell cycle from G0 to G1
  • Quiescent cells are in a physiologic state (G0) and can occasionally enter the cell cycle
  • For quiescent cells to enter the cell cycle, transcriptional genes, including proto-oncogenes and genes needed for ribosome synthesis and protein translation, must be activated

Cell Cycle Controls and Redundancies

  • The cell cycle has multiple controls and redundancies, especially during the transition from G1 to S phases
  • Essential gene function defects can stop the cell cycle

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Description

Quiz on the cell cycle, proto-oncogenes, and their role in cell proliferation and cancer. Diagrams of the cell cycle are included.

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