Cancer Genes and Cell Cycle Control

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DNA changes that lead to cancer are always inherited from parents.

False

Overactivation of proto-oncogenes and deactivation of tumor suppressor genes can both lead to uncontrolled cell growth and the development of a tumor.

True

Mutations in the BRCA1 and BRCA2 genes are always inherited and cannot be acquired through environmental factors.

False

The Ras protein is a transcription factor that regulates cell proliferation.

False Signup and view all the answers

To analyze possible cancer-causing mutations, you should always sample the tumor tissue itself.

True Signup and view all the answers

Mutations within coding regions of a gene are more likely to impact the final protein product compared to mutations within introns.

True Signup and view all the answers

Mutations in tumor suppressor genes or proto-oncogenes always result in uncontrolled cell proliferation and cancer.

False Signup and view all the answers

Cell cycle checkpoints play no role in the development of cancer.

False Signup and view all the answers

Germ line mutations are only passed on to future generations, while somatic mutations have no impact on the individual.

False Signup and view all the answers

DNA mutations that alter the amino acid sequence of a protein are more likely to impact its structure and function compared to mutations that do not change the amino acid sequence.

True Signup and view all the answers

Chromosomal rearrangements are considered large scale alterations in the genome.

True Signup and view all the answers

Substitutions in protein coding regions can have a minimal or major effect on the resulting protein.

True Signup and view all the answers

Frameshift mutations are more likely to cause a catastrophic effect if the mutation occurs at the 3' end of the mRNA.

False Signup and view all the answers

Nonsense mutations always result in a truncated protein.

True Signup and view all the answers

Insertions and deletions of 3 nucleotides in the coding sequence can maintain the reading frame.

True Signup and view all the answers

Mutations in genes that normally regulate cell proliferation can lead to uncontrolled cell growth and cancer.

True Signup and view all the answers

DNA mutations that cause cancer are always inherited from parents.

False Signup and view all the answers

The Maturation Promoting Factor (MPF) is a complex of cyclin and cyclin-dependent kinase (Cdk) that is essential for the G2 checkpoint.

True Signup and view all the answers

Mutations in the $p53$ gene are an example of a genetic predisposition to cancer that can be inherited.

True Signup and view all the answers

The G2 checkpoint ensures that DNA replication is complete before the cell enters mitosis.

False Signup and view all the answers

A point mutation that changes the UUU codon to UUG results in a missense substitution.

True Signup and view all the answers

Huntington's Disease is caused by a frameshift mutation.

False Signup and view all the answers

In sickle cell anemia, a missense mutation in the $\beta$-globin gene leads to abnormal hemoglobin structure and function.

True Signup and view all the answers

Cell cycle checkpoints ensure that the cell has undamaged DNA and appropriate signals before proceeding to the next phase.

True Signup and view all the answers

Mutations in genes involved in cell cycle regulation can lead to uncontrolled cell proliferation and cancer.

True Signup and view all the answers

Cancer Genes and Cell Cycle Control

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Questions and Answers

DNA changes that lead to cancer are always inherited from parents.

Overactivation of proto-oncogenes and deactivation of tumor suppressor genes can both lead to uncontrolled cell growth and the development of a tumor.

Mutations in the BRCA1 and BRCA2 genes are always inherited and cannot be acquired through environmental factors.

The Ras protein is a transcription factor that regulates cell proliferation.

To analyze possible cancer-causing mutations, you should always sample the tumor tissue itself.

Mutations within coding regions of a gene are more likely to impact the final protein product compared to mutations within introns.

Mutations in tumor suppressor genes or proto-oncogenes always result in uncontrolled cell proliferation and cancer.

Cell cycle checkpoints play no role in the development of cancer.

Germ line mutations are only passed on to future generations, while somatic mutations have no impact on the individual.

DNA mutations that alter the amino acid sequence of a protein are more likely to impact its structure and function compared to mutations that do not change the amino acid sequence.

Chromosomal rearrangements are considered large scale alterations in the genome.

Substitutions in protein coding regions can have a minimal or major effect on the resulting protein.

Frameshift mutations are more likely to cause a catastrophic effect if the mutation occurs at the 3' end of the mRNA.

Nonsense mutations always result in a truncated protein.

Insertions and deletions of 3 nucleotides in the coding sequence can maintain the reading frame.

Mutations in genes that normally regulate cell proliferation can lead to uncontrolled cell growth and cancer.

DNA mutations that cause cancer are always inherited from parents.

The Maturation Promoting Factor (MPF) is a complex of cyclin and cyclin-dependent kinase (Cdk) that is essential for the G2 checkpoint.

Mutations in the $p53$ gene are an example of a genetic predisposition to cancer that can be inherited.

The G2 checkpoint ensures that DNA replication is complete before the cell enters mitosis.

A point mutation that changes the UUU codon to UUG results in a missense substitution.

Huntington's Disease is caused by a frameshift mutation.

In sickle cell anemia, a missense mutation in the $\beta$-globin gene leads to abnormal hemoglobin structure and function.

Cell cycle checkpoints ensure that the cell has undamaged DNA and appropriate signals before proceeding to the next phase.

Mutations in genes involved in cell cycle regulation can lead to uncontrolled cell proliferation and cancer.

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