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Cell Biology M Checkpoint Quiz

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@SpotlessFarce

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Questions and Answers

What does the spindle checkpoint ensure before allowing the cell cycle to proceed?

Sister chromatids are attached to spindle microtubules. (correct)

The nuclear envelope has disintegrated.

The cell has completed cytokinesis.

All chromosomes are duplicated correctly.

What happens to the cell if a chromosome is found to be misplaced during the spindle checkpoint?

The cell proceeds with mitosis without delay.

The cell enters a resting phase until all chromosomes are verified.

The cell pauses mitosis to capture the stray chromosome. (correct)

The cell undergoes apoptosis immediately.

How do cells identify misplaced chromosomes during the spindle checkpoint?

By detecting chromosomes floating in the cytoplasm. (correct)

By checking for incomplete centromere formation.

By assessing the length of the spindle microtubules.

By scanning the metaphase plate for total chromosome presence.

Why is the spindle checkpoint considered critical during mitosis?

<p>It prevents the irreversible separation of sister chromatids if not all are attached.</p> Signup and view all the answers

What is another name for the spindle checkpoint?

<p>M checkpoint</p> Signup and view all the answers

Study Notes

Spindle Checkpoint (M checkpoint)

Examines if sister chromatids are correctly attached to spindle microtubules.
Anaphase is irreversible, so the cell cycle won't proceed until all chromosomes are securely attached to spindle fibers from both cell poles.
The cell doesn't check every chromosome's position; it looks for misplaced ("straggler") chromosomes.
If a chromosome is misplaced, the cell pauses mitosis, giving time for the spindle to capture it.

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Description

Test your knowledge on the spindle checkpoint in cell biology. This checkpoint is crucial for ensuring that sister chromatids are correctly attached to spindle microtubules before anaphase can occur. Understanding the mechanisms behind this checkpoint is essential for comprehending cell division and chromosomal stability.