Cell Biology M Checkpoint Quiz

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Questions and Answers

What does the spindle checkpoint ensure before allowing the cell cycle to proceed?

  • Sister chromatids are attached to spindle microtubules. (correct)
  • The nuclear envelope has disintegrated.
  • The cell has completed cytokinesis.
  • All chromosomes are duplicated correctly.

What happens to the cell if a chromosome is found to be misplaced during the spindle checkpoint?

  • The cell proceeds with mitosis without delay.
  • The cell enters a resting phase until all chromosomes are verified.
  • The cell pauses mitosis to capture the stray chromosome. (correct)
  • The cell undergoes apoptosis immediately.

How do cells identify misplaced chromosomes during the spindle checkpoint?

  • By detecting chromosomes floating in the cytoplasm. (correct)
  • By checking for incomplete centromere formation.
  • By assessing the length of the spindle microtubules.
  • By scanning the metaphase plate for total chromosome presence.

Why is the spindle checkpoint considered critical during mitosis?

<p>It prevents the irreversible separation of sister chromatids if not all are attached. (D)</p> Signup and view all the answers

What is another name for the spindle checkpoint?

<p>M checkpoint (B)</p> Signup and view all the answers

Flashcards

Spindle Checkpoint

A cell cycle checkpoint that ensures all sister chromatids are correctly attached to spindle microtubules before anaphase.

M Checkpoint

Another name for the Spindle Checkpoint.

Sister Chromatids Attachment

Crucial for correct chromosome segregation during cell division.

Anaphase

Stage of mitosis where sister chromatids separate.

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Spindle Microtubules

Protein fibers that guide chromosome movement during cell division.

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Chromosome Attachment

Chromosomes must be attached to spindle fibers from opposite poles.

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Misplaced Chromosome

Chromosome not properly aligned or attached to spindle microtubules

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Study Notes

Spindle Checkpoint (M checkpoint)

  • Examines if sister chromatids are correctly attached to spindle microtubules.
  • Anaphase is irreversible, so the cell cycle won't proceed until all chromosomes are securely attached to spindle fibers from both cell poles.
  • The cell doesn't check every chromosome's position; it looks for misplaced ("straggler") chromosomes.
  • If a chromosome is misplaced, the cell pauses mitosis, giving time for the spindle to capture it.

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