Mitotic Spindle and Chromosome Movement Quiz
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Questions and Answers

What is the function of the mitotic spindle?

  • Stores genetic information
  • Produces energy for the cell
  • Regulates cell division
  • Controls chromosome movement during mitosis (correct)
  • Where does the assembly of spindle microtubules begin during prophase?

  • Centrosome (correct)
  • Nucleus
  • Mitochondria
  • Cytoplasm
  • What happens during anaphase of mitosis?

  • Sister chromatids separate and move toward opposite ends of the cell (correct)
  • Spindle microtubules attach to kinetochores
  • Centrosomes replicate
  • Chromosomes line up at the metaphase plate
  • What occurs at metaphase during mitosis?

    <p>Chromosomes are all lined up at the metaphase plate</p> Signup and view all the answers

    What happens in telophase of mitosis?

    <p>Genetically identical daughter nuclei form at opposite ends of the cell</p> Signup and view all the answers

    What is cytokinesis?

    <p>Process during which the cytoplasm of the cell divides into two new cells</p> Signup and view all the answers

    What is the main distinction between living things and nonliving matter?

    <p>The ability to reproduce</p> Signup and view all the answers

    Which type of cell division produces nonidentical daughter cells?

    <p>Meiosis</p> Signup and view all the answers

    What is the name of the narrow 'waist' of a duplicated chromosome?

    <p>Centromere</p> Signup and view all the answers

    In eukaryotic cells, what is the term for the genetic material consisting of DNA and protein?

    <p>Chromatin</p> Signup and view all the answers

    Which phase of the cell cycle involves cell growth and copying of chromosomes in preparation for cell division?

    <p>S phase</p> Signup and view all the answers

    What is the term for the long threadlike association of genes in a cell?

    <p>Chromatin</p> Signup and view all the answers

    Which type of cells have half as many chromosomes as somatic cells?

    <p>Gametes</p> Signup and view all the answers

    What distinguishes mitosis from meiosis?

    <p>Mitosis results in genetically identical daughter cells, while meiosis results in nonidentical daughter cells.</p> Signup and view all the answers

    What is the function of cell division in multicellular organisms?

    <p>To promote growth and development</p> Signup and view all the answers

    Which term describes the life of a cell from its formation to its own division?

    <p>Cell cycle</p> Signup and view all the answers

    What is the stage where a cell can withdraw from the cell cycle or enter the G0 stage?

    <p>G0 stage</p> Signup and view all the answers

    Which regulatory proteins are involved in cell division?

    <p>Cyclins</p> Signup and view all the answers

    Which process reduces the chromosome number by half and leads to genetic diversity?

    <p>Meiosis</p> Signup and view all the answers

    What is the result of unregulated cell cycle division?

    <p>Cancer</p> Signup and view all the answers

    Which phase of meiosis involves separation of homologous chromosomes?

    <p>Prophase I</p> Signup and view all the answers

    What is the term for the inheritance from two parents, containing two copies of each gene?

    <p>Biparental inheritance</p> Signup and view all the answers

    Which syndrome is characterized by an extra X chromosome (XXY)?

    <p>Klinefelter's Syndrome</p> Signup and view all the answers

    What is the significance of meiosis in terms of gamete development?

    <p>Generates genetic variability in gametes</p> Signup and view all the answers

    Which phase of the cell cycle is critical for monitoring physiological conditions in the cell?

    <p>G2 checkpoint</p> Signup and view all the answers

    What is the purpose of the M checkpoint in cell division?

    <p>To initiate cytokinesis</p> Signup and view all the answers

    What is chromatin composed of in the eukaryotic interphase nucleus?

    <p>DNA, RNA, histones, and nonhistone proteins</p> Signup and view all the answers

    Which phase of the cell cycle is the initial stage between divisions?

    <p>Interphase</p> Signup and view all the answers

    What is the role of mitosis in adult organisms?

    <p>Wound healing and cell replacement</p> Signup and view all the answers

    Which protein complex holds sister chromatids together during mitosis?

    <p>Cohesin</p> Signup and view all the answers

    What happens during telophase of mitosis?

    <p>Daughter chromosomes arrive at the poles and cytokinesis commences</p> Signup and view all the answers

    What is the importance of mitotic activity in a fertilized egg (zygote)?

    <p>Leads to the development and growth of the organism</p> Signup and view all the answers

    Study Notes

    Cell Division and Genetics

    • The ability of organisms to reproduce distinguishes living things from nonliving matter.
    • Cell division is an integral part of the cell cycle, which is the life of a cell from formation to its own division.

    Cell Division Results in Genetically Identical Daughter Cells

    • Most cell division results in daughter cells with identical genetic information, DNA.
    • A special type of division produces nonidentical daughter cells (gametes, or sperm and egg cells).

    Cellular Organization of the Genetic Material

    • The DNA in a cell constitutes the cell's genome.
    • A genome can consist of a single DNA molecule (common in prokaryotic cells) or a number of DNA molecules (common in eukaryotic cells).
    • DNA molecules in a cell are packaged into chromosomes.
    • Every eukaryotic species has a characteristic number of chromosomes in each cell nucleus.
    • Somatic cells (nonreproductive cells) have two sets of chromosomes.
    • Gametes (reproductive cells: sperm and eggs) have half as many chromosomes as somatic cells.

    Distribution of Chromosomes During Eukaryotic Cell Division

    • In preparation for cell division, DNA is replicated and the chromosomes condense.
    • Each duplicated chromosome has two sister chromatids, which separate during cell division.
    • The centromere is the narrow “waist” of the duplicated chromosome, where the two chromatids are most closely attached.

    Mitosis and Meiosis

    • Mitosis is the division of the nucleus, followed by cytokinesis, the division of the cytoplasm.
    • Meiosis is a variation of cell division that yields nonidentical daughter cells that have only one set of chromosomes, half as many as the parent cell.

    Cell Cycle

    • The cell cycle consists of:
      • Mitotic (M) phase (mitosis and cytokinesis)
      • Interphase (cell growth and copying of chromosomes in preparation for cell division)
    • Interphase can be divided into subphases:
      • G1 phase (“first gap”)
      • S phase (“synthesis”)
      • G2 phase (“second gap”)
    • The cell grows during all three phases, but chromosomes are duplicated only during the S phase.

    Structure of DNA and Chromosomes

    • Chromosomes are long threadlike associations of genes, consisting of DNA (40%) and protein (60%).
    • Chromatin is the complex of DNA, RNA, histones, and nonhistone proteins that make up uncoiled chromosomes, characteristic of the eukaryotic interphase nucleus.
    • Nucleosomes are nuclear complexes consisting of four pairs of histone molecules wrapped by two turns of a DNA molecule.
    • The centromere is the location of the narrow “waist” of the duplicated chromosome.

    Mitosis Importance

    • Mitosis provides the basis for asexual reproduction (single-celled organisms: protozoans and some fungi and algae).
    • Mitotic activity of the zygote (fertilized egg) leads to the development and growth of the organism.
    • In adult organisms, mitosis is involved in wound healing and other forms of cell replacement.
    • In abnormal conditions, mitotic activity can lead to tumors.

    Phases of Mitosis

    • Prophase: Chromosomes coil up and condense; centrioles divide and move apart.
    • Prometaphase: Chromosomes are clearly double structures; centrioles reach the opposite poles; spindle fibers form.
    • Metaphase: Centromeres align on the metaphase plate.
    • Anaphase: Centromeres split, and daughter chromosomes migrate to opposite poles.
    • Telophase: Daughter chromosomes arrive at the poles; cytokinesis commences.

    Mitotic Spindle

    • The mitotic spindle is an apparatus of microtubules that controls chromosome movement during mitosis.
    • The spindle includes the centrosomes, the spindle microtubules, and the asters.

    Cell Cycle Regulation

    • The frequency of cell division varies with the type of cell.
    • Cell cycle differences result from regulation at the molecular level.
    • Regulatory mechanisms of cell division include G1, G2, and M checkpoints.
    • Cyclins and cyclin-dependent kinases (CDKs) are regulatory proteins involved in cell cycle control.

    Meiosis

    • Meiosis is a process that halves the chromosome number, resulting in gametes (sperm and egg cells).
    • Meiosis involves two rounds of nuclear division, resulting in four haploid daughter cells.
    • Meiosis increases genetic diversity through the shuffling of genes during gamete formation.
    • Meiosis involves the separation of homologous chromosomes and the separation of sister chromatids.

    Phases of Meiosis

    • Meiosis I:
      • Prophase I: pairing and disjunction of sister chromatids
      • Metaphase I: separation of homologous chromosomes
      • Anaphase I: separation of sister chromatids
      • Telophase I: formation of two haploid cells
    • Meiosis II:
      • Prophase II: separation of sister chromatids
      • Metaphase II: separation of sister chromatids
      • Anaphase II: separation of sister chromatids
      • Telophase II: formation of four haploid gametes

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    Test your knowledge on the mitotic spindle, microtubules, and chromosome movement during mitosis. Explore concepts such as spindle assembly, centrosome replication, and sister chromatid disjunction.

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