Cell Biology Chapter: Tumors and Cell Proliferation
46 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which of the following statements accurately describes the process of cell proliferation?

  • A process that primarily involves the differentiation of cells into specialized types.
  • A rapid and successive increase in the number of cells through cell division. (correct)
  • A decrease in the number of cells due to cell death.
  • An increase in the size of existing cells without cell division.
  • What is the main characteristic that distinguishes a benign tumor from a malignant tumor?

  • Benign tumors are always asymptomatic, while malignant tumors cause symptoms.
  • Benign tumors do not spread to other parts of the body, while malignant tumors can metastasize. (correct)
  • Benign tumors are always caused by genetic mutations, while malignant tumors are not.
  • Benign tumors are always larger than malignant tumors.
  • Which of the following is NOT a characteristic of a tumor marker?

  • Tumor markers can be used to monitor the effectiveness of cancer treatment.
  • Tumor markers are used to screen for cancer in asymptomatic individuals.
  • Tumor markers are always present in the blood of individuals with cancer. (correct)
  • Tumor markers are substances produced by cancer cells or by the body in response to cancer.
  • What is the primary cause behind the development of tumors?

    <p>Abnormal regulation of cell division and growth. (A)</p> Signup and view all the answers

    Which of the following best describes the term 'abnormally regulated cell division' in the context of tumor formation?

    <p>An uncontrolled and excessive increase in the rate of cell division, leading to tumor growth. (D)</p> Signup and view all the answers

    Which of the following conditions is NOT a type of cellular adaptation?

    <p>Metastasis (D)</p> Signup and view all the answers

    What is the primary characteristic of a tumor?

    <p>It is a swelling or lesion caused by an abnormal growth of cells. (B)</p> Signup and view all the answers

    What is the difference between hypertrophy and hyperplasia?

    <p>Hypertrophy involves an increase in cell size, while hyperplasia involves an increase in cell number. (D)</p> Signup and view all the answers

    Which statement BEST explains the difference between a tumor and metastasis?

    <p>A tumor is a localized growth, while metastasis is the spread of cancer cells to other areas. (C)</p> Signup and view all the answers

    What contributes to the likelihood of a tumor metastasizing?

    <p>The size, aggression, and growth rate of the primary tumor. (B)</p> Signup and view all the answers

    Metaplasia is defined as:

    <p>The change of one cell type to another cell type. (C)</p> Signup and view all the answers

    Which of the following can NOT cause atrophy?

    <p>Exercise (A)</p> Signup and view all the answers

    Hyperplasia is most likely to occur in tissues that have:

    <p>A high rate of mitosis. (D)</p> Signup and view all the answers

    What is the main function of Fas/Fas ligand (FasL/CD95L/CD178)?

    <p>To initiate apoptosis by activating a caspase cascade. (A)</p> Signup and view all the answers

    What is 'MOMP' in the context of the provided text?

    <p>Mitochondrial Outer Membrane Permeabilization (C)</p> Signup and view all the answers

    Which of the following is NOT a sign or symptom of cancer, as mentioned in the text?

    <p>Loss of appetite. (C)</p> Signup and view all the answers

    Which of the following is a risk factor for cancer, according to the provided text?

    <p>Exposure to ionizing radiation. (B)</p> Signup and view all the answers

    What is the significance of angiogenesis for cancer development?

    <p>Angiogenesis provides a pathway for tumor cells to spread to distant sites. (C)</p> Signup and view all the answers

    What type of protein is involved in the recognition, binding, or adhesion process, as mentioned in the text?

    <p>Immunoglobulin superfamily (C)</p> Signup and view all the answers

    What is the primary difference between necrosis and apoptosis?

    <p>Necrosis is associated with inflammation, while apoptosis is not. (A)</p> Signup and view all the answers

    Which of the following is a type of angiogenesis mentioned in the text?

    <p>Healthy angiogenesis (A)</p> Signup and view all the answers

    What is the primary function of the signal transduction pathway in relation to cell growth?

    <p>It regulates both cell cycle progression and apoptosis. (D)</p> Signup and view all the answers

    Which of the following phases is NOT part of mitosis, but is included in the cell cycle?

    <p>Interphase (A)</p> Signup and view all the answers

    What is the role of the p53 protein in relation to apoptosis?

    <p>It prevents the division of cells with damaged DNA. (A)</p> Signup and view all the answers

    What is the primary function of the Bcl-2 family of proteins in the context of apoptosis?

    <p>Regulating the mitochondrial pathway of apoptosis. (C)</p> Signup and view all the answers

    How does apoptosis contribute to tissue remodeling during growth and development?

    <p>By eliminating excess or damaged cells. (C)</p> Signup and view all the answers

    What is the relationship between the cell cycle and apoptosis?

    <p>Apoptosis is a crucial checkpoint in the cell cycle. (C)</p> Signup and view all the answers

    What is the significance of the statement, "Often, a tumor that fits this description can still be treated, however, extending the life of the patient"?

    <p>It highlights the possibility of treatment even for seemingly aggressive tumors. (B)</p> Signup and view all the answers

    Which of the following is NOT a factor that can contribute to unhealthy angiogenesis?

    <p>Cancer (D)</p> Signup and view all the answers

    What is the primary function of adhesion molecules in the body?

    <p>To regulate the migration of leukocytes to sites of inflammation. (D)</p> Signup and view all the answers

    Which class of adhesion molecules is involved in the interaction of cells with the extracellular matrix?

    <p>Integrins (B)</p> Signup and view all the answers

    Which of the following is NOT a key benefit of early cancer detection?

    <p>Increased risk of developing secondary cancers. (B)</p> Signup and view all the answers

    What is the main goal of searching for cancer biomarkers?

    <p>To enable early cancer detection. (C)</p> Signup and view all the answers

    Which of the following statements regarding therapeutic angiogenesis is TRUE?

    <p>It involves the creation of new blood vessels to improve blood flow to ischemic areas. (B)</p> Signup and view all the answers

    Which of the following is a characteristic of tumor markers?

    <p>They can be produced by both cancerous and non-cancerous cells. (D)</p> Signup and view all the answers

    What is the primary characteristic of unhealthy angiogenesis?

    <p>The formation of blood vessels in inappropriate locations. (D)</p> Signup and view all the answers

    What is the primary reason why monoclonal antibodies are used in tumor marker immunoassays?

    <p>They offer a greater level of specificity and sensitivity. (A)</p> Signup and view all the answers

    Which of the following is a potential consequence of a high concentration of a tumor marker in serum?

    <p>The immunoassay may produce an artificially low result. (B)</p> Signup and view all the answers

    What is the primary function of CA 15-3 as a tumor marker?

    <p>Monitor the clinical course of patients with breast cancer. (D)</p> Signup and view all the answers

    Which of the following techniques is NOT commonly used to measure tumor markers?

    <p>Gas Chromatography-Mass Spectrometry (GC-MS) (C)</p> Signup and view all the answers

    Which of the following methods is used to correct the hook effect in immunoassays?

    <p>Diluting the sample. (C)</p> Signup and view all the answers

    Which of the following conditions can lead to elevated levels of CA 15-3?

    <p>Hepatitis (B)</p> Signup and view all the answers

    Which of the following is considered the most sensitive and specific marker for monitoring the clinical course of metastatic breast cancer?

    <p>CA 15-3 (C)</p> Signup and view all the answers

    What is the primary role of Alpha-fetoprotein (AFP) as a tumor marker?

    <p>To monitor the clinical course of patients with liver cancer. (D)</p> Signup and view all the answers

    Which of the following is a characteristic of the tumor marker CA 15-3?

    <p>It is a glycoprotein with multiple epitopes. (A)</p> Signup and view all the answers

    Which of the following statements accurately describes the relationship between tumor markers and patient outcomes?

    <p>Monitoring tumor marker levels can be useful in assessing the effectiveness of treatment. (B)</p> Signup and view all the answers

    Flashcards

    Proliferation

    The process of increasing in number by cell division.

    Benign Tumor

    A type of tumor that is non-cancerous and generally does not spread.

    Malignant Tumor

    A cancerous tumor that can invade nearby tissues and spread.

    Cell Growth

    The overall process by which cells increase in size and number.

    Signup and view all the flashcards

    Tumor Markers

    Substances that can be found in the blood, urine, or tissue to help identify tumor presence.

    Signup and view all the flashcards

    Cancer

    A disease characterized by abnormal growth of cells that can be life-threatening.

    Signup and view all the flashcards

    Atrophy

    Decrease in size of fully matured cells, often due to insufficient oxygen or disuse.

    Signup and view all the flashcards

    Hyperplasia

    Increase in the number of cells in an organ or tissue, which is controlled and useful.

    Signup and view all the flashcards

    Hypertrophy

    Increase in size of cells that do not divide, like muscle cells.

    Signup and view all the flashcards

    Metaplasia

    Change of one cell type to another in response to stimuli.

    Signup and view all the flashcards

    Metastasis

    When cancer cells spread from the original tumor to other body parts.

    Signup and view all the flashcards

    Tumor

    An abnormal mass of tissue formed by uncontrolled cell growth that does not serve a purpose.

    Signup and view all the flashcards

    Cellular Adaptation

    The process of cells adjusting to changes to maintain homeostasis, such as atrophy or hyperplasia.

    Signup and view all the flashcards

    Therapeutic Angiogenesis

    The process of inducing blood vessel formation to aid in healing ischemic tissues.

    Signup and view all the flashcards

    Unhealthy Angiogenesis

    Abnormal growth and branching of blood vessels, often linked to diseases like cancer.

    Signup and view all the flashcards

    Cancer Biomarkers

    Biological indicators used to detect the presence of cancer early.

    Signup and view all the flashcards

    Adhesion Molecules

    Transmembrane glycoproteins that help cells stick and interact during migration.

    Signup and view all the flashcards

    Selectins

    A class of adhesion molecules involved in white blood cells and platelet interactions.

    Signup and view all the flashcards

    Integrins

    Adhesion molecules that facilitate cell interaction with extracellular matrix components.

    Signup and view all the flashcards

    Early Cancer Detection

    Identifying cancer at an initial stage for better treatment outcomes.

    Signup and view all the flashcards

    Tumor Response

    The reaction of tumor cells to adhesion molecules, affecting their behavior and metastasis.

    Signup and view all the flashcards

    Apoptosis

    Programmed cell death, a natural self-destruct system in all cells.

    Signup and view all the flashcards

    Signal Transduction Pathway

    The transmission of growth-regulatory messages to control cell replication and apoptosis.

    Signup and view all the flashcards

    Cell Cycle

    The series of phases a cell goes through to replicate, including G1, S, G2, and M phases.

    Signup and view all the flashcards

    Interphase

    The phase of the cell cycle where the cell is resting and performing functions, not part of mitosis.

    Signup and view all the flashcards

    G1 Phase

    The first phase of the cell cycle, where the cell grows and prepares for DNA replication.

    Signup and view all the flashcards

    p53 Protein

    A protein that prevents cells with damaged DNA from dividing or promotes apoptosis when damage is too severe.

    Signup and view all the flashcards

    Bcl-2

    A family of proteins that regulate apoptosis by promoting or inhibiting the process.

    Signup and view all the flashcards

    Markers for Apoptosis

    Indicators like p53 and Bcl-2 that regulate the apoptosis process in cells.

    Signup and view all the flashcards

    Outer Membrane Permeabilization (MOMP)

    A key step in the intrinsic pathway of apoptosis, leading to cell death.

    Signup and view all the flashcards

    Fas/Fas Ligand

    A receptor-ligand system that activates apoptosis via caspase cascade.

    Signup and view all the flashcards

    Immunoglobulin Superfamily

    Large proteins (like IgD, IgM) involved in immune recognition and adhesion.

    Signup and view all the flashcards

    Signs and Symptoms of Cancer

    Indicators like changes in habits, wounds that won't heal, or unusual bleeds.

    Signup and view all the flashcards

    Necrosis

    Cell death linked to inflammation, often seen in tissue damage.

    Signup and view all the flashcards

    Angiogenesis

    The process of forming new blood vessels, essential for tumor growth.

    Signup and view all the flashcards

    Cancer Risk Factors

    Factors like age, diet, and family history that increase cancer risk.

    Signup and view all the flashcards

    Monoclonal Antibodies

    Antibodies produced by identical immune cells that are clones of a unique parent cell, often used in immunoassays.

    Signup and view all the flashcards

    Immunoassay

    A laboratory method used to detect and quantify proteins or hormones using the immune response.

    Signup and view all the flashcards

    Hook Effect

    A phenomenon in immunoassays where very high concentrations of a substance lead to falsely low results.

    Signup and view all the flashcards

    Dilution Remedy

    A method to counteract the hook effect by lowering the concentration of the sample.

    Signup and view all the flashcards

    CA 15-3

    A tumor marker associated with breast cancer, represented by specific epitopes on mucin glycoprotein.

    Signup and view all the flashcards

    A1-fetoprotein (AFP)

    A major fetal serum protein that typically decreases to adult levels by 7-10 months of age.

    Signup and view all the flashcards

    High Performance Liquid Chromatography (HPLC)

    A technique used to separate and analyze compounds in a sample, often used for catecholamines.

    Signup and view all the flashcards

    Immunohistochemistry

    A method combining immunology and histology to identify proteins in tissue sections.

    Signup and view all the flashcards

    Enzyme Assay

    A test to measure the activity of enzymes, used in diagnosing various diseases.

    Signup and view all the flashcards

    Breast Cancer Monitoring

    The process of tracking the clinical status of patients using sensitive tumor markers like CA 15-3 and AFP.

    Signup and view all the flashcards

    Study Notes

    Tumor Markers

    • Tumor markers are substances produced by tumor cells or other body cells in response to cancer or other conditions
    • They can be found in blood, urine, or tumor tissue, or other tissues
    • Different types of markers are found in different types
    • Levels of the same marker can change in different types of cancers
    • Tumor marker levels may not change in all patients with cancer, especially early stage
    • Levels can change in people with non-cancerous conditions
    • Clinical value depends on specificity and sensitivity, and intended use
    • Example: PSA (prostate specific antigen) used to screen for prostate cancer

    Two Major Processes in Cell Growth

    • Proliferation: Increase in cell number through cell division, crucial for replacing cells
    • Differentiation: Changes in cell characteristics, transforming cells into specialized types, crucial for repair/replacement (e.g., zygote, stem cells)

    Definitions of Terms

    • Oncogenesis: Emergence of tumor cells when cell growth/development isn't controlled
    • Tumorigenesis: Development of a tumor; the uncontrolled growth of new cells that serve no purpose in the body
    • Tumor: An abnormal new mass of tissue resulting from a cell that lost its normal growth control, often enlarging uncontrollably
    • Neoplasia: abnormal, uncontrolled cellular hyperplasia
    • Hyperplasia: multiplication of cells
    • Hypertrophy: increase in cell size
    • Atrophy: Decrease in size of cells
    • Metaplasia: one cell type changing to another
    • Malignant: cancerous, aggressive, invades nearby tissues, spreads to distant locations (metastasizes)
    • Benign: Not cancerous, grows slowly, usually harmless; doesn't spread to other parts of the body
    • Cellular Adaptation: Adjustments in cell size/characteristics due to external factors (blood supply, pressure, hormones)
    • Metasis: Cancer cells breaking off the primary tumor and traveling to other parts of the body

    Types of Tumors

    • Benign: Slow growth, usually harmless, doesn't spread
    • Malignant: Cancerous, fast growth, spreads to other tissues and organs

    Cellular Adaptation

    • Atrophy: Decrease in cell size.
    • Hyperplasia: Increase in cell number.
    • Hypertrophy: Increase in cell size.
    • Metaplasia: Change in cell type.

    Cancer and Cells

    • Old cells do not die when they should, and new cells are created even if the body doesn't need them.
    • Cancer results from unregulated cell division.
    • Abnormal cell growth causes tumors (swelling or lesions).

    Metastasis

    • Occurs when cancer cells break off the primary tumor and travel to other parts of the body.
    • It's a multistep process involving interactions between tumor cells and host cells/tissue.

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Related Documents

    Description

    Test your understanding of cell proliferation and tumor biology with this quiz. It covers key concepts such as tumor characteristics, cellular adaptations, and factors contributing to tumor development. Challenge yourself on the distinctions between benign and malignant tumors as well as the processes involved in cell division.

    More Like This

    Il Processo Tumorale: Fasi e Meccanismi
    33 questions
    Microambiente e cellule tumorali
    30 questions
    Nowotworzenie i tkanka nowotworowa
    40 questions
    Cell Biology: Telomeres and Tumor Cells
    5 questions
    Use Quizgecko on...
    Browser
    Browser