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Questions and Answers
Which of the following statements accurately describes the process of cell proliferation?
Which of the following statements accurately describes the process of cell proliferation?
What is the main characteristic that distinguishes a benign tumor from a malignant tumor?
What is the main characteristic that distinguishes a benign tumor from a malignant tumor?
Which of the following is NOT a characteristic of a tumor marker?
Which of the following is NOT a characteristic of a tumor marker?
What is the primary cause behind the development of tumors?
What is the primary cause behind the development of tumors?
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Which of the following best describes the term 'abnormally regulated cell division' in the context of tumor formation?
Which of the following best describes the term 'abnormally regulated cell division' in the context of tumor formation?
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Which of the following conditions is NOT a type of cellular adaptation?
Which of the following conditions is NOT a type of cellular adaptation?
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What is the primary characteristic of a tumor?
What is the primary characteristic of a tumor?
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What is the difference between hypertrophy and hyperplasia?
What is the difference between hypertrophy and hyperplasia?
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Which statement BEST explains the difference between a tumor and metastasis?
Which statement BEST explains the difference between a tumor and metastasis?
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What contributes to the likelihood of a tumor metastasizing?
What contributes to the likelihood of a tumor metastasizing?
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Metaplasia is defined as:
Metaplasia is defined as:
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Which of the following can NOT cause atrophy?
Which of the following can NOT cause atrophy?
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Hyperplasia is most likely to occur in tissues that have:
Hyperplasia is most likely to occur in tissues that have:
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What is the main function of Fas/Fas ligand (FasL/CD95L/CD178)?
What is the main function of Fas/Fas ligand (FasL/CD95L/CD178)?
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What is 'MOMP' in the context of the provided text?
What is 'MOMP' in the context of the provided text?
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Which of the following is NOT a sign or symptom of cancer, as mentioned in the text?
Which of the following is NOT a sign or symptom of cancer, as mentioned in the text?
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Which of the following is a risk factor for cancer, according to the provided text?
Which of the following is a risk factor for cancer, according to the provided text?
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What is the significance of angiogenesis for cancer development?
What is the significance of angiogenesis for cancer development?
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What type of protein is involved in the recognition, binding, or adhesion process, as mentioned in the text?
What type of protein is involved in the recognition, binding, or adhesion process, as mentioned in the text?
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What is the primary difference between necrosis and apoptosis?
What is the primary difference between necrosis and apoptosis?
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Which of the following is a type of angiogenesis mentioned in the text?
Which of the following is a type of angiogenesis mentioned in the text?
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What is the primary function of the signal transduction pathway in relation to cell growth?
What is the primary function of the signal transduction pathway in relation to cell growth?
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Which of the following phases is NOT part of mitosis, but is included in the cell cycle?
Which of the following phases is NOT part of mitosis, but is included in the cell cycle?
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What is the role of the p53 protein in relation to apoptosis?
What is the role of the p53 protein in relation to apoptosis?
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What is the primary function of the Bcl-2 family of proteins in the context of apoptosis?
What is the primary function of the Bcl-2 family of proteins in the context of apoptosis?
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How does apoptosis contribute to tissue remodeling during growth and development?
How does apoptosis contribute to tissue remodeling during growth and development?
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What is the relationship between the cell cycle and apoptosis?
What is the relationship between the cell cycle and apoptosis?
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What is the significance of the statement, "Often, a tumor that fits this description can still be treated, however, extending the life of the patient"?
What is the significance of the statement, "Often, a tumor that fits this description can still be treated, however, extending the life of the patient"?
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Which of the following is NOT a factor that can contribute to unhealthy angiogenesis?
Which of the following is NOT a factor that can contribute to unhealthy angiogenesis?
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What is the primary function of adhesion molecules in the body?
What is the primary function of adhesion molecules in the body?
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Which class of adhesion molecules is involved in the interaction of cells with the extracellular matrix?
Which class of adhesion molecules is involved in the interaction of cells with the extracellular matrix?
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Which of the following is NOT a key benefit of early cancer detection?
Which of the following is NOT a key benefit of early cancer detection?
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What is the main goal of searching for cancer biomarkers?
What is the main goal of searching for cancer biomarkers?
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Which of the following statements regarding therapeutic angiogenesis is TRUE?
Which of the following statements regarding therapeutic angiogenesis is TRUE?
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Which of the following is a characteristic of tumor markers?
Which of the following is a characteristic of tumor markers?
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What is the primary characteristic of unhealthy angiogenesis?
What is the primary characteristic of unhealthy angiogenesis?
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What is the primary reason why monoclonal antibodies are used in tumor marker immunoassays?
What is the primary reason why monoclonal antibodies are used in tumor marker immunoassays?
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Which of the following is a potential consequence of a high concentration of a tumor marker in serum?
Which of the following is a potential consequence of a high concentration of a tumor marker in serum?
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What is the primary function of CA 15-3 as a tumor marker?
What is the primary function of CA 15-3 as a tumor marker?
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Which of the following techniques is NOT commonly used to measure tumor markers?
Which of the following techniques is NOT commonly used to measure tumor markers?
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Which of the following methods is used to correct the hook effect in immunoassays?
Which of the following methods is used to correct the hook effect in immunoassays?
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Which of the following conditions can lead to elevated levels of CA 15-3?
Which of the following conditions can lead to elevated levels of CA 15-3?
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Which of the following is considered the most sensitive and specific marker for monitoring the clinical course of metastatic breast cancer?
Which of the following is considered the most sensitive and specific marker for monitoring the clinical course of metastatic breast cancer?
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What is the primary role of Alpha-fetoprotein (AFP) as a tumor marker?
What is the primary role of Alpha-fetoprotein (AFP) as a tumor marker?
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Which of the following is a characteristic of the tumor marker CA 15-3?
Which of the following is a characteristic of the tumor marker CA 15-3?
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Which of the following statements accurately describes the relationship between tumor markers and patient outcomes?
Which of the following statements accurately describes the relationship between tumor markers and patient outcomes?
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Flashcards
Proliferation
Proliferation
The process of increasing in number by cell division.
Benign Tumor
Benign Tumor
A type of tumor that is non-cancerous and generally does not spread.
Malignant Tumor
Malignant Tumor
A cancerous tumor that can invade nearby tissues and spread.
Cell Growth
Cell Growth
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Tumor Markers
Tumor Markers
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Cancer
Cancer
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Atrophy
Atrophy
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Hyperplasia
Hyperplasia
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Hypertrophy
Hypertrophy
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Metaplasia
Metaplasia
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Metastasis
Metastasis
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Tumor
Tumor
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Cellular Adaptation
Cellular Adaptation
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Therapeutic Angiogenesis
Therapeutic Angiogenesis
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Unhealthy Angiogenesis
Unhealthy Angiogenesis
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Cancer Biomarkers
Cancer Biomarkers
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Adhesion Molecules
Adhesion Molecules
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Selectins
Selectins
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Integrins
Integrins
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Early Cancer Detection
Early Cancer Detection
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Tumor Response
Tumor Response
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Apoptosis
Apoptosis
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Signal Transduction Pathway
Signal Transduction Pathway
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Cell Cycle
Cell Cycle
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Interphase
Interphase
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G1 Phase
G1 Phase
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p53 Protein
p53 Protein
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Bcl-2
Bcl-2
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Markers for Apoptosis
Markers for Apoptosis
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Outer Membrane Permeabilization (MOMP)
Outer Membrane Permeabilization (MOMP)
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Fas/Fas Ligand
Fas/Fas Ligand
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Immunoglobulin Superfamily
Immunoglobulin Superfamily
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Signs and Symptoms of Cancer
Signs and Symptoms of Cancer
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Necrosis
Necrosis
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Angiogenesis
Angiogenesis
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Cancer Risk Factors
Cancer Risk Factors
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Monoclonal Antibodies
Monoclonal Antibodies
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Immunoassay
Immunoassay
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Hook Effect
Hook Effect
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Dilution Remedy
Dilution Remedy
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CA 15-3
CA 15-3
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A1-fetoprotein (AFP)
A1-fetoprotein (AFP)
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High Performance Liquid Chromatography (HPLC)
High Performance Liquid Chromatography (HPLC)
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Immunohistochemistry
Immunohistochemistry
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Enzyme Assay
Enzyme Assay
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Breast Cancer Monitoring
Breast Cancer Monitoring
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Study Notes
Tumor Markers
- Tumor markers are substances produced by tumor cells or other body cells in response to cancer or other conditions
- They can be found in blood, urine, or tumor tissue, or other tissues
- Different types of markers are found in different types
- Levels of the same marker can change in different types of cancers
- Tumor marker levels may not change in all patients with cancer, especially early stage
- Levels can change in people with non-cancerous conditions
- Clinical value depends on specificity and sensitivity, and intended use
- Example: PSA (prostate specific antigen) used to screen for prostate cancer
Two Major Processes in Cell Growth
- Proliferation: Increase in cell number through cell division, crucial for replacing cells
- Differentiation: Changes in cell characteristics, transforming cells into specialized types, crucial for repair/replacement (e.g., zygote, stem cells)
Definitions of Terms
- Oncogenesis: Emergence of tumor cells when cell growth/development isn't controlled
- Tumorigenesis: Development of a tumor; the uncontrolled growth of new cells that serve no purpose in the body
- Tumor: An abnormal new mass of tissue resulting from a cell that lost its normal growth control, often enlarging uncontrollably
- Neoplasia: abnormal, uncontrolled cellular hyperplasia
- Hyperplasia: multiplication of cells
- Hypertrophy: increase in cell size
- Atrophy: Decrease in size of cells
- Metaplasia: one cell type changing to another
- Malignant: cancerous, aggressive, invades nearby tissues, spreads to distant locations (metastasizes)
- Benign: Not cancerous, grows slowly, usually harmless; doesn't spread to other parts of the body
- Cellular Adaptation: Adjustments in cell size/characteristics due to external factors (blood supply, pressure, hormones)
- Metasis: Cancer cells breaking off the primary tumor and traveling to other parts of the body
Types of Tumors
- Benign: Slow growth, usually harmless, doesn't spread
- Malignant: Cancerous, fast growth, spreads to other tissues and organs
Cellular Adaptation
- Atrophy: Decrease in cell size.
- Hyperplasia: Increase in cell number.
- Hypertrophy: Increase in cell size.
- Metaplasia: Change in cell type.
Cancer and Cells
- Old cells do not die when they should, and new cells are created even if the body doesn't need them.
- Cancer results from unregulated cell division.
- Abnormal cell growth causes tumors (swelling or lesions).
Metastasis
- Occurs when cancer cells break off the primary tumor and travel to other parts of the body.
- It's a multistep process involving interactions between tumor cells and host cells/tissue.
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Description
Test your understanding of cell proliferation and tumor biology with this quiz. It covers key concepts such as tumor characteristics, cellular adaptations, and factors contributing to tumor development. Challenge yourself on the distinctions between benign and malignant tumors as well as the processes involved in cell division.