Questions and Answers
What is the drug class of Celecoxib?
What are the indications for Celecoxib?
Relief of osteoarthritis, management of acute pain, primary dysmenorrhea, reduce intestinal polyps.
What are the contraindications for using Celecoxib?
Hypersensitivity, perioperative pain in the setting of CABG.
List some side effects of Celecoxib.
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What is the recommended dosage of Celecoxib?
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What precautions should be taken when using Celecoxib?
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What is the mechanism of action of Celecoxib?
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Study Notes
Drug Overview
- Celecoxib, marketed as Celebrex, belongs to the drug class of NSAID COX-2 inhibitors, targeting cyclooxygenase-2 to alleviate pain and inflammation.
Indications
- Effective for relieving osteoarthritis symptoms and managing acute pain.
- Used to treat primary dysmenorrhea and to reduce intestinal polyps.
Contraindications
- Not suitable for individuals with hypersensitivity to the drug.
- Contraindicated for patients experiencing perioperative pain during coronary artery bypass graft (CABG) surgery.
- Black Box Warning (BBW) present, indicating significant risks.
Side Effects
- Common side effects include hypertension, gastrointestinal disorders, and headaches.
- Severe reactions can entail myocardial infarction (MI), liver failure, anaphylactic reactions, and acute renal failure.
Dosage
- Typical starting dosage is 200 mg per day, which can be administered as a single dose or split into two doses.
- Dosage can be increased to a maximum of 400 mg per day based on patient needs.
Precautions
- Use with caution in patients with a history of asthma, bleeding issues, ulcers, or recurring heartburn.
- Consider potential risks for patients with a history of angina, heart attacks, high blood pressure, strokes, anemia, bleeding/clotting disorders, and nasal polyps.
Mechanism of Action
- Celecoxib primarily inhibits the conversion of arachidonic acid into prostaglandin precursors.
- This mechanism underpins its antipyretic (fever-reducing), analgesic (pain-relieving), and anti-inflammatory properties.
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Description
This quiz provides essential flashcards focusing on the NSAID Celecoxib (Celebrex). It covers drug classification, indications, contraindications, and potential side effects. Perfect for medical students or healthcare professionals looking to reinforce their knowledge about this medication.
