Questions and Answers
What is the generic name of Celebrex?
Celebrex is classified as a COX-1 inhibitor.
False
What is the therapeutic classification of Celebrex?
Antirheumatics, nonsteroidal anti-inflammatory agents
The pregnancy category of Celebrex is _____ in the first and second trimesters and D in the third trimester.
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What are the main actions of Celebrex?
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Celebrex is contraindicated in patients with _____ hypersensitivity.
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What enzyme does Celebrex inhibit?
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Name two uses of Celebrex.
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Which of the following is a precaution when using Celebrex?
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Study Notes
Celebrex (Celecoxib) Overview
- Celebrex is the brand name for the generic drug celecoxib.
- It is classified as a nonsteroidal anti-inflammatory drug (NSAID) specifically as a COX-2 inhibitor.
Drug Classification
- Therapeutic Classification: Antirheumatics, nonsteroidal anti-inflammatory agents.
- Pharmacologic Classification: COX-2 inhibitors, analgesics, cyclooxygenase-2 inhibitors, and antipyretics.
Pregnancy Category
- Categorized as C during the first and second trimesters, and D during the third trimester, indicating potential risks.
Actions and Mechanism of Action (MOA)
- Celebrex exhibits analgesic, anti-inflammatory, and antipyretic effects.
- It selectively inhibits the COX-2 enzyme, reducing prostaglandin synthesis without affecting COX-1, differentiating it from other NSAIDs like ibuprofen.
Therapeutic Effects
- Provides relief from pain and inflammation associated with arthritis and spondylitis.
- Effective in treating acute pain and primary dysmenorrhea.
- Reduces polyp formation in patients with familial adenomatous polyposis (FAP) and ankylosing spondylitis.
Contraindications and Precautions
- Not suitable for individuals with hypersensitivity to celecoxib or cross-sensitivity to other NSAIDs (including aspirin).
- Should be avoided in patients with asthma, urticaria, and allergic reactions to NSAIDs (asthma triad).
- Contraindicated in cases of advanced renal disease and severe hepatic dysfunction.
- Caution is required for patients undergoing peri-operative pain management from coronary artery bypass graft (CABG) surgery.
- Use in late pregnancy is not recommended due to the risk of premature closure of the ductus arteriosus.
Cautious Use
- Recommended for patients who are P450 2C9 poor metabolizers or those with specific weight considerations, necessitating careful monitoring during treatment.
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Description
This quiz features flashcards focused on Celebrex (celecoxib), including its generic name, brand, and classification. Each card provides key information about the drug's therapeutic and pharmacologic properties as well as its pregnancy category. Perfect for students or professionals looking to reinforce their knowledge of Celebrex.
